ID   PANS_SALTY              Reviewed;         313 AA.
AC   Q8ZKL0;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Pantothenate precursors transporter PanS {ECO:0000305};
GN   Name=panS {ECO:0000303|PubMed:25645561};
GN   OrderedLocusNames=STM4195 {ECO:0000312|EMBL:AAL23019.1};
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   FUNCTION AS A TRANSPORTER.
RC   STRAIN=LT2;
RX   PubMed=25645561; DOI=10.1128/jb.02506-14;
RA   Ernst D.C., Downs D.M.;
RT   "The STM4195 gene product (PanS) transports coenzyme A precursors in
RT   Salmonella enterica.";
RL   J. Bacteriol. 197:1368-1377(2015).
CC   -!- FUNCTION: Transports ketopantoate, pantoate and, to a lesser extent,
CC       pantothenate into the cell. Can also transport a product of coenzyme A
CC       (CoA) degradation that serves as a precursor to CoA and enters the
CC       biosynthetic pathway between PanC and CoaBC.
CC       {ECO:0000269|PubMed:25645561}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC       2.A.28) family. {ECO:0000305}.
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DR   EMBL; AE006468; AAL23019.1; -; Genomic_DNA.
DR   RefSeq; NP_463060.1; NC_003197.2.
DR   RefSeq; WP_000881652.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZKL0; -.
DR   SMR; Q8ZKL0; -.
DR   STRING; 99287.STM4195; -.
DR   PaxDb; Q8ZKL0; -.
DR   DNASU; 1255721; -.
DR   EnsemblBacteria; AAL23019; AAL23019; STM4195.
DR   GeneID; 1255721; -.
DR   KEGG; stm:STM4195; -.
DR   PATRIC; fig|99287.12.peg.4409; -.
DR   HOGENOM; CLU_034788_1_1_6; -.
DR   OMA; QFTIMPL; -.
DR   PhylomeDB; Q8ZKL0; -.
DR   BioCyc; SENT99287:STM4195-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR004710; Bilac:Na_transpt.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR10361; PTHR10361; 1.
DR   Pfam; PF01758; SBF; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..313
FT                   /note="Pantothenate precursors transporter PanS"
FT                   /id="PRO_0000433089"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  33154 MW;  7EF1F476EED8F4D4 CRC64;
     MLAVITRLFP LWALLLSLTA YYTPSTFTPV GPWVATLLML IMFGMGVHLN VDDFKRVLSR
     PAPVAAGIFL HYLVMPLAAW LLALLFKMPP DLSAGMVLVG SVASGTASNV MIYLAKGDVA
     LSVTISSVST LVGVVATPLL TRLYVDAHIQ VDVMGMLLSI LQIVVIPITL GLVIHHLFPR
     VVKVVKPYLP AFSMVCILAI ISAVVAGSAS HIASVGFMVI IAVILHNTLG LLGGYWGGRL
     FGFDESTCRT LAIEVGMQNS GLAAALGKIY FGPLAALPGA LFSVWHNLSG SLLAGYWSGK
     PIVEKSGETA KVN