PANT_LEUMM
ID PANT_LEUMM Reviewed; 204 AA.
AC Q03YI6;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Pantothenate transporter PanT;
DE AltName: Full=Pantothenic acid ECF transporter S component PanT;
GN Name=panT; OrderedLocusNames=LEUM_0623;
OS Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 / DSM
OS 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523 / NBRC 100496 / NCIMB
OS 8023 / NCTC 12954 / NRRL B-1118 / 37Y).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Leuconostoc.
OX NCBI_TaxID=203120;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523
RC / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
RN [2]
RP SUBUNIT, SUBCELLULAR LOCATION, AND EXPRESSION IN E.COLI.
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523
RC / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y;
RX PubMed=18931129; DOI=10.1128/jb.01208-08;
RA Rodionov D.A., Hebbeln P., Eudes A., ter Beek J., Rodionova I.A.,
RA Erkens G.B., Slotboom D.J., Gelfand M.S., Osterman A.L., Hanson A.D.,
RA Eitinger T.;
RT "A novel class of modular transporters for vitamins in prokaryotes.";
RL J. Bacteriol. 191:42-51(2009).
RN [3]
RP FUNCTION AS A TRANSPORT COMPONENT, SUBCELLULAR LOCATION, SUBUNIT, AND
RP EXPRESSION IN E.COLI.
RC STRAIN=ATCC 8293 / DSM 20343 / BCRC 11652 / CCM 1803 / JCM 6124 / NCDO 523
RC / NBRC 100496 / NCIMB 8023 / NCTC 12954 / NRRL B-1118 / 37Y;
RX PubMed=19717603; DOI=10.1128/jb.00965-09;
RA Neubauer O., Alfandega A., Schoknecht J., Sternberg U., Pohlmann A.,
RA Eitinger T.;
RT "Two essential arginine residues in the T components of energy-coupling
RT factor transporters.";
RL J. Bacteriol. 191:6482-6488(2009).
CC -!- FUNCTION: Probable pantothenate-binding protein that interacts with the
CC energy-coupling factor (ECF) ABC-transporter complex. Unlike classic
CC ABC transporters this ECF transporter provides the energy necessary to
CC transport a number of different substrates. The substrates themselves
CC are bound by transmembrane, not extracytoplasmic soluble proteins and
CC transport it into cells. Upon coexpression with its energy-coupling
CC factor (ECF) ABC-transporter complex EcfA1A2T in E.coli allows
CC pantothenate uptake; uptake requires both PanT and EcfA1A2T.
CC {ECO:0000269|PubMed:19717603}.
CC -!- SUBUNIT: In E.coli forms a stable energy-coupling factor (ECF)
CC transporter complex probably composed of a membrane-embedded substrate-
CC binding protein (S component), two ATP-binding proteins (A components)
CC and a transmembrane protein (T component).
CC {ECO:0000269|PubMed:18931129, ECO:0000269|PubMed:19717603}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:18931129,
CC ECO:0000305|PubMed:19717603}; Multi-pass membrane protein
CC {ECO:0000305|PubMed:18931129, ECO:0000305|PubMed:19717603}.
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DR EMBL; CP000414; ABJ61736.1; -; Genomic_DNA.
DR RefSeq; WP_004164419.1; NC_008531.1.
DR AlphaFoldDB; Q03YI6; -.
DR SMR; Q03YI6; -.
DR STRING; 203120.LEUM_0623; -.
DR TCDB; 2.A.87.2.1; the prokaryotic riboflavin transporter (p-rft) family.
DR EnsemblBacteria; ABJ61736; ABJ61736; LEUM_0623.
DR GeneID; 61176900; -.
DR KEGG; lme:LEUM_0623; -.
DR eggNOG; COG4684; Bacteria.
DR HOGENOM; CLU_088550_0_0_9; -.
DR OMA; QAWSTPG; -.
DR OrthoDB; 1466380at2; -.
DR Proteomes; UP000000362; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR024529; ECF_trnsprt_substrate-spec.
DR Pfam; PF12822; ECF_trnsprt; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..204
FT /note="Pantothenate transporter PanT"
FT /id="PRO_0000409013"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 204 AA; 21943 MW; 5E555489556FBC85 CRC64;
MSNNKTKYLV ITTFFMAIIL LQVLIPWLGY IPLGAVIVGA QPTIIQFTVA IAAILLGARR
GAFIGGFWGL LTLWQAWSTP GSIGSLMFQN PFTAFIPRIL VGLIIGMAFN KWLRNKNFGF
RTLGLGFLGG LAALINTVGV VLLTVIGFTV MRTNFTGIPN HNLLGWLIGI VSFNSIFEII
TGIILVAAIG NVLVPIAERA GIKG
