PANX3_HUMAN
ID PANX3_HUMAN Reviewed; 392 AA.
AC Q96QZ0;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Pannexin-3;
GN Name=PANX3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15028292; DOI=10.1016/j.ygeno.2003.09.025;
RA Baranova A., Ivanov D., Petrash N., Pestova A., Skoblov M., Kelmanson I.,
RA Shagin D., Nazarenko S., Geraymovych E., Litvin O., Tiunova A., Born T.L.,
RA Usman N., Staroverov D., Lukyanov S., Panchin Y.;
RT "The mammalian pannexin family is homologous to the invertebrate innexin
RT gap junction proteins.";
RL Genomics 83:706-716(2004).
CC -!- FUNCTION: Structural component of the gap junctions and the
CC hemichannels.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap
CC junction.
CC -!- SIMILARITY: Belongs to the pannexin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00351}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Pannexin entry;
CC URL="https://en.wikipedia.org/wiki/Pannexin";
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DR EMBL; AF406650; AAK95655.1; -; mRNA.
DR CCDS; CCDS8447.1; -.
DR RefSeq; NP_443191.1; NM_052959.2.
DR AlphaFoldDB; Q96QZ0; -.
DR SMR; Q96QZ0; -.
DR BioGRID; 125498; 2.
DR IntAct; Q96QZ0; 1.
DR STRING; 9606.ENSP00000284288; -.
DR TCDB; 1.A.25.2.3; the gap junction-forming innexin (innexin) family.
DR GlyGen; Q96QZ0; 1 site.
DR iPTMnet; Q96QZ0; -.
DR PhosphoSitePlus; Q96QZ0; -.
DR BioMuta; PANX3; -.
DR DMDM; 20139071; -.
DR jPOST; Q96QZ0; -.
DR PaxDb; Q96QZ0; -.
DR PRIDE; Q96QZ0; -.
DR ProteomicsDB; 77913; -.
DR Antibodypedia; 53990; 94 antibodies from 21 providers.
DR DNASU; 116337; -.
DR Ensembl; ENST00000284288.3; ENSP00000284288.2; ENSG00000154143.3.
DR GeneID; 116337; -.
DR KEGG; hsa:116337; -.
DR MANE-Select; ENST00000284288.3; ENSP00000284288.2; NM_052959.3; NP_443191.1.
DR UCSC; uc001qah.4; human.
DR CTD; 116337; -.
DR DisGeNET; 116337; -.
DR GeneCards; PANX3; -.
DR HGNC; HGNC:20573; PANX3.
DR HPA; ENSG00000154143; Not detected.
DR MIM; 608422; gene.
DR neXtProt; NX_Q96QZ0; -.
DR OpenTargets; ENSG00000154143; -.
DR PharmGKB; PA134920643; -.
DR VEuPathDB; HostDB:ENSG00000154143; -.
DR eggNOG; ENOG502QRDI; Eukaryota.
DR GeneTree; ENSGT00940000153972; -.
DR HOGENOM; CLU_050054_1_0_1; -.
DR InParanoid; Q96QZ0; -.
DR OMA; SDPYVFW; -.
DR OrthoDB; 623546at2759; -.
DR PhylomeDB; Q96QZ0; -.
DR TreeFam; TF333142; -.
DR PathwayCommons; Q96QZ0; -.
DR SignaLink; Q96QZ0; -.
DR BioGRID-ORCS; 116337; 12 hits in 1064 CRISPR screens.
DR GenomeRNAi; 116337; -.
DR Pharos; Q96QZ0; Tbio.
DR PRO; PR:Q96QZ0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96QZ0; protein.
DR Bgee; ENSG00000154143; Expressed in tibia and 18 other tissues.
DR Genevisible; Q96QZ0; HS.
DR GO; GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005198; F:structural molecule activity; ISS:UniProtKB.
DR GO; GO:0022829; F:wide pore channel activity; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0032732; P:positive regulation of interleukin-1 production; IEA:InterPro.
DR InterPro; IPR000990; Innexin.
DR InterPro; IPR039099; Pannexin.
DR PANTHER; PTHR15759; PTHR15759; 1.
DR Pfam; PF00876; Innexin; 1.
DR PROSITE; PS51013; PANNEXIN; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Gap junction; Glycoprotein; Ion channel;
KW Ion transport; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..392
FT /note="Pannexin-3"
FT /id="PRO_0000208491"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 61..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 135..215
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 237..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"
FT TOPO_DOM 289..392
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 95
FT /note="G -> R (in dbSNP:rs34498516)"
FT /id="VAR_034367"
FT VARIANT 208
FT /note="T -> A (in dbSNP:rs35569094)"
FT /id="VAR_034368"
SQ SEQUENCE 392 AA; 44683 MW; 8988F5DCC6E1B050 CRC64;
MSLAHTAAEY MLSDALLPDR RGPRLKGLRL ELPLDRIVKF VAVGSPLLLM SLAFAQEFSS
GSPISCFSPS NFSIRQAAYV DSSCWDSLLH HKQDGPGQDK MKSLWPHKAL PYSLLALALL
MYLPVLLWQY AAVPALSSDL LFIISELDKS YNRSIRLVQH MLKIRQKSSD PYVFWNELEK
ARKERYFEFP LLERYLACKQ RSHSLVATYL LRNSLLLIFT SATYLYLGHF HLDVFFQEEF
SCSIKTGLLS DETHVPNLIT CRLTSLSIFQ IVSLSSVAIY TILVPVIIYN LTRLCRWDKR
LLSVYEMLPA FDLLSRKMLG CPINDLNVIL LFLRANISEL ISFSWLSVLC VLKDTTTQKH
NIDTVVDFMT LLAGLEPSKP KHLTNSACDE HP
