PAO1_VESOR
ID PAO1_VESOR Reviewed; 152 AA.
AC Q7M3V4;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=Orientotoxin-1;
DE EC=3.1.1.5;
DE AltName: Full=Lysophospholipase;
DE AltName: Full=Orientotoxin I;
OS Vespa orientalis (Oriental hornet).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC Vespidae; Vespinae; Vespa.
OX NCBI_TaxID=7447;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Venom;
RX PubMed=2742606;
RA Korneev A.S., Salikhov S.I., Tuychibaev M.U.;
RT "Amino acid sequence of orientotoxin I and orientotoxin II from the hornet
RT Vespa orientalis venom.";
RL Bioorg. Khim. 15:127-129(1989).
CC -!- FUNCTION: Neurotoxin of presynaptic effect which degrades
CC lysophospholipids.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR PIR; JN0426; JN0426.
DR AlphaFoldDB; Q7M3V4; -.
DR SMR; Q7M3V4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism;
KW Neurotoxin; Presynaptic neurotoxin; Secreted; Toxin.
FT CHAIN 1..152
FT /note="Orientotoxin-1"
FT /id="PRO_0000058226"
SQ SEQUENCE 152 AA; 16929 MW; 34ED8FA20D978032 CRC64;
FNPCPYSDDT VKMIILTEQN KKQDFYTLDT IGEHNQFNKL TAKSQVVFIV WQTGIGDAIT
ARAGYIFLLD SGLAMLVDKY QMAPVASDIK LCNAGCYCKP TYVISVKKAI QFAWEHKCVG
IRCSDPGVPT DGLSGRPHYG ETLHKVRSYN GK