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PAO1_VESOR
ID   PAO1_VESOR              Reviewed;         152 AA.
AC   Q7M3V4;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Orientotoxin-1;
DE            EC=3.1.1.5;
DE   AltName: Full=Lysophospholipase;
DE   AltName: Full=Orientotoxin I;
OS   Vespa orientalis (Oriental hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=7447;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=2742606;
RA   Korneev A.S., Salikhov S.I., Tuychibaev M.U.;
RT   "Amino acid sequence of orientotoxin I and orientotoxin II from the hornet
RT   Vespa orientalis venom.";
RL   Bioorg. Khim. 15:127-129(1989).
CC   -!- FUNCTION: Neurotoxin of presynaptic effect which degrades
CC       lysophospholipids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC         H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC         ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR   PIR; JN0426; JN0426.
DR   AlphaFoldDB; Q7M3V4; -.
DR   SMR; Q7M3V4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism;
KW   Neurotoxin; Presynaptic neurotoxin; Secreted; Toxin.
FT   CHAIN           1..152
FT                   /note="Orientotoxin-1"
FT                   /id="PRO_0000058226"
SQ   SEQUENCE   152 AA;  16929 MW;  34ED8FA20D978032 CRC64;
     FNPCPYSDDT VKMIILTEQN KKQDFYTLDT IGEHNQFNKL TAKSQVVFIV WQTGIGDAIT
     ARAGYIFLLD SGLAMLVDKY QMAPVASDIK LCNAGCYCKP TYVISVKKAI QFAWEHKCVG
     IRCSDPGVPT DGLSGRPHYG ETLHKVRSYN GK
 
 
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