PAP1L_HUMAN
ID PAP1L_HUMAN Reviewed; 614 AA.
AC Q4VXU2; Q4VY17;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Polyadenylate-binding protein 1-like;
GN Name=PABPC1L; Synonyms=C20orf119;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Sakugawa N.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q4VXU2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4VXU2-2; Sequence=VSP_057071, VSP_057072;
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000305}.
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DR EMBL; EU190483; ABY64766.1; -; mRNA.
DR EMBL; AL109839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL008725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001118228.1; NM_001124756.2.
DR AlphaFoldDB; Q4VXU2; -.
DR SMR; Q4VXU2; -.
DR BioGRID; 123246; 24.
DR IntAct; Q4VXU2; 7.
DR STRING; 9606.ENSP00000255136; -.
DR iPTMnet; Q4VXU2; -.
DR PhosphoSitePlus; Q4VXU2; -.
DR SwissPalm; Q4VXU2; -.
DR BioMuta; PABPC1L; -.
DR DMDM; 74754038; -.
DR EPD; Q4VXU2; -.
DR jPOST; Q4VXU2; -.
DR MassIVE; Q4VXU2; -.
DR MaxQB; Q4VXU2; -.
DR PaxDb; Q4VXU2; -.
DR PeptideAtlas; Q4VXU2; -.
DR PRIDE; Q4VXU2; -.
DR ProteomicsDB; 62357; -. [Q4VXU2-1]
DR ProteomicsDB; 62366; -.
DR Antibodypedia; 72120; 58 antibodies from 7 providers.
DR Ensembl; ENST00000255136.8; ENSP00000255136.3; ENSG00000101104.13. [Q4VXU2-1]
DR Ensembl; ENST00000537323.5; ENSP00000445661.1; ENSG00000101104.13. [Q4VXU2-2]
DR UCSC; uc010ggv.1; human. [Q4VXU2-1]
DR GeneCards; PABPC1L; -.
DR HGNC; HGNC:15797; PABPC1L.
DR HPA; ENSG00000101104; Low tissue specificity.
DR neXtProt; NX_Q4VXU2; -.
DR OpenTargets; ENSG00000101104; -.
DR PharmGKB; PA162398552; -.
DR VEuPathDB; HostDB:ENSG00000101104; -.
DR eggNOG; KOG0123; Eukaryota.
DR GeneTree; ENSGT00940000157106; -.
DR HOGENOM; CLU_012062_22_6_1; -.
DR InParanoid; Q4VXU2; -.
DR OrthoDB; 1027234at2759; -.
DR PhylomeDB; Q4VXU2; -.
DR TreeFam; TF300458; -.
DR PathwayCommons; Q4VXU2; -.
DR SignaLink; Q4VXU2; -.
DR BioGRID-ORCS; 80336; 13 hits in 1080 CRISPR screens.
DR ChiTaRS; PABPC1L; human.
DR GenomeRNAi; 80336; -.
DR Pharos; Q4VXU2; Tbio.
DR PRO; PR:Q4VXU2; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q4VXU2; protein.
DR Bgee; ENSG00000101104; Expressed in body of pancreas and 144 other tissues.
DR ExpressionAtlas; Q4VXU2; baseline and differential.
DR Genevisible; Q4VXU2; HS.
DR GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IBA:GO_Central.
DR GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR Pfam; PF00658; PABP; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00360; RRM; 4.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR SUPFAM; SSF63570; SSF63570; 1.
DR TIGRFAMs; TIGR01628; PABP-1234; 1.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS50102; RRM; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..614
FT /note="Polyadenylate-binding protein 1-like"
FT /id="PRO_0000277879"
FT DOMAIN 11..89
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 99..175
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 191..268
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 294..370
FT /note="RRM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 528..605
FT /note="PABC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00641"
FT REGION 431..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..457
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 325..330
FT /note="VMTEGG -> KRRQRP (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_057071"
FT VAR_SEQ 331..614
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_057072"
FT VARIANT 212
FT /note="S -> A (in dbSNP:rs2075960)"
FT /id="VAR_054047"
FT VARIANT 492
FT /note="S -> G (in dbSNP:rs6513956)"
FT /id="VAR_060184"
SQ SEQUENCE 614 AA; 68392 MW; 3A809F527CE688FF CRC64;
MNASGSGYPL ASLYVGDLHP DVTEAMLYEK FSPAGPILSI RVCRDVATRR SLGYAYINFQ
QPADAERALD TMNFEMLKGQ PIRIMWSQRD PGLRKSGVGN IFIKNLEDSI DNKALYDTFS
TFGNILSCKV ACDEHGSRGF GFVHFETHEA AQQAINTMNG MLLNDRKVFV GHFKSRRERE
AELGARALEF TNIYVKNLPV DVDEQGLQDL FSQFGKMLSV KVMRDNSGHS RCFGFVNFEK
HEEAQKAVVH MNGKEVSGRL LYAGRAQKRV ERQNELKRRF EQMKQDRLRR YQGVNLYVKN
LDDSIDDDKL RKEFSPYGVI TSAKVMTEGG HSKGFGFVCF SSPEEATKAV TEMNGRIVGT
KPLYVALAQR KEERKAILTN QYMQRLSTMR TLSNPLLGSF QQPSSYFLPA MPQPPAQAAY
YGCGPVTPTQ PAPRWTSQPP RPSCASMVRP PVVPRRPPAH ISSVRQASTQ VPRTVPHTQR
VANIGTQTTG PSGVGCCTPG RPLLPCKCSS AAHSTYRVQE PAVHIPGQEP LTASMLAAAP
LHEQKQMIGE RLYPLIHDVH TQLAGKITGM LLEIDNSELL LMLESPESLH AKIDEAVAVL
QAHQAMEQPK AYMH
