PAP1M_HUMAN
ID PAP1M_HUMAN Reviewed; 200 AA.
AC Q5JQF8; B2RMV9; Q8IVU8;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Polyadenylate-binding protein 1-like 2;
DE AltName: Full=RNA-binding motif protein 32;
DE AltName: Full=RNA-binding protein 32;
GN Name=PABPC1L2A; Synonyms=PABPC1L2, RBM32A;
GN and
GN Name=PABPC1L2B; Synonyms=PABPC1L2, RBM32B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- MISCELLANEOUS: May be not functional as it lacks the poly(A)-binding
CC protein C-terminal (PABC) domain implicated in the mRNA stability and
CC translation regulation.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH41956.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL662864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471104; EAW98671.1; -; Genomic_DNA.
DR EMBL; BC041956; AAH41956.1; ALT_INIT; mRNA.
DR EMBL; BC136492; AAI36493.1; -; mRNA.
DR CCDS; CCDS35334.1; -.
DR CCDS; CCDS43972.1; -.
DR RefSeq; NP_001012995.1; NM_001012977.2.
DR RefSeq; NP_001035971.1; NM_001042506.1.
DR AlphaFoldDB; Q5JQF8; -.
DR SMR; Q5JQF8; -.
DR BioGRID; 131067; 6.
DR IntAct; Q5JQF8; 3.
DR MINT; Q5JQF8; -.
DR STRING; 9606.ENSP00000362618; -.
DR iPTMnet; Q5JQF8; -.
DR PhosphoSitePlus; Q5JQF8; -.
DR BioMuta; PABPC1L2A; -.
DR DMDM; 74755614; -.
DR jPOST; Q5JQF8; -.
DR MassIVE; Q5JQF8; -.
DR PaxDb; Q5JQF8; -.
DR PeptideAtlas; Q5JQF8; -.
DR PRIDE; Q5JQF8; -.
DR ProteomicsDB; 63045; -.
DR Antibodypedia; 27980; 27 antibodies from 7 providers.
DR Antibodypedia; 72608; 50 antibodies from 12 providers.
DR DNASU; 340529; -.
DR Ensembl; ENST00000373519.1; ENSP00000362618.1; ENSG00000186288.5.
DR Ensembl; ENST00000373521.4; ENSP00000362621.3; ENSG00000184388.6.
DR GeneID; 340529; -.
DR GeneID; 645974; -.
DR KEGG; hsa:340529; -.
DR KEGG; hsa:645974; -.
DR MANE-Select; ENST00000373519.1; ENSP00000362618.1; NM_001012977.3; NP_001012995.1.
DR MANE-Select; ENST00000373521.4; ENSP00000362621.3; NM_001042506.2; NP_001035971.1.
DR UCSC; uc004ebf.4; human.
DR CTD; 340529; -.
DR CTD; 645974; -.
DR GeneCards; PABPC1L2A; -.
DR GeneCards; PABPC1L2B; -.
DR HGNC; HGNC:27989; PABPC1L2A.
DR HGNC; HGNC:31852; PABPC1L2B.
DR HPA; ENSG00000184388; Group enriched (brain, pituitary gland, prostate, salivary gland, testis).
DR HPA; ENSG00000186288; Tissue enhanced (brain, prostate).
DR neXtProt; NX_Q5JQF8; -.
DR OpenTargets; ENSG00000184388; -.
DR OpenTargets; ENSG00000186288; -.
DR PharmGKB; PA162398594; -.
DR VEuPathDB; HostDB:ENSG00000184388; -.
DR VEuPathDB; HostDB:ENSG00000186288; -.
DR eggNOG; KOG0123; Eukaryota.
DR GeneTree; ENSGT00940000160311; -.
DR HOGENOM; CLU_012062_22_1_1; -.
DR InParanoid; Q5JQF8; -.
DR OMA; HQGYAFA; -.
DR OrthoDB; 1027234at2759; -.
DR PhylomeDB; Q5JQF8; -.
DR PathwayCommons; Q5JQF8; -.
DR BioGRID-ORCS; 340529; 9 hits in 579 CRISPR screens.
DR BioGRID-ORCS; 645974; 24 hits in 601 CRISPR screens.
DR Pharos; Q5JQF8; Tdark.
DR PRO; PR:Q5JQF8; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q5JQF8; protein.
DR Bgee; ENSG00000184388; Expressed in endothelial cell and 40 other tissues.
DR Genevisible; Q5JQF8; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..200
FT /note="Polyadenylate-binding protein 1-like 2"
FT /id="PRO_0000304509"
FT DOMAIN 2..80
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 90..166
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 170..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 32
FT /note="R -> S (in Ref. 3; AAH41956)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 200 AA; 22799 MW; BEF8BB66BE807DE7 CRC64;
MASLYVGDLH PEVTEAMLYE KFSPAGPILS IRICRDKITR RSLGYAYVNY QQPVDAKRAL
ETLNFDVIKG RPVRIMWSQR DPSLRKSGVG NVFIKNLGKT IDNKALYNIF SAFGNILSCK
VACDEKGPKG YGFVHFQKQE SAERAIDVMN GMFLNYRKIF VGRFKSHKER EAERGAWARQ
STSADVKDFE EDTDEEATLR
