ID   PAP1_DPV84              Reviewed;         470 AA.
AC   Q08FE1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   29-SEP-2021, entry version 52.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
GN   Name=PAPL; OrderedLocusNames=DpV84gp040;
OS   Deerpox virus (strain W-1170-84) (DPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Cervidpoxvirus.
OX   NCBI_TaxID=305676;
OH   NCBI_TaxID=9872; Odocoileus hemionus (Mule deer) (Cervus hemionus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15613325; DOI=10.1128/jvi.79.2.966-977.2005;
RA   Afonso C.L., Delhon G., Tulman E.R., Lu Z., Zsak A., Becerra V.M., Zsak L.,
RA   Kutish G.F., Rock D.L.;
RT   "Genome of deerpox virus.";
RL   J. Virol. 79:966-977(2005).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AY689437; ABI99025.1; -; Genomic_DNA.
DR   SMR; Q08FE1; -.
DR   Proteomes; UP000162522; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004652; F:polynucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1270.320; -; 1.
DR   Gene3D; 3.30.460.60; -; 1.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; Pox_polyA_pol_nucTrfase.
DR   InterPro; IPR038419; Pox_polyA_pol_nucTrfase_sf.
DR   InterPro; IPR004976; Poxviridae_polyA_pol_cat.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; SSF160957; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Transcription;
KW   Transferase.
FT   CHAIN           1..470
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000308930"
FT   ACT_SITE        192
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   470 AA;  54089 MW;  2AA5851274C44B4A CRC64;
     MNRHISEILE KYLGRIPSLT EYHTLKSQYK NIHRVNIFNK DIFISLIKKN KKKFFSDIDT
     SVSEIKKLVF DYFTKQEQTY SIGKLYTIIE LQTILVTTYT DILGVLTTKG PDIFSSNVQY
     NTSSMQKIAS DALNSMNIAT ISDKVMGRHN VSSLVCNVNS LMEEYLRRHN KSCICYGSYS
     LHLLNPEIKY GDIDILQTNS RTFLIDLAFL IKFITGYNVI LLKVPYLKNY MVLKDQNDSH
     IIDSFNIRQE TMQHIPKVLI DNIYIVDPTI QLLSMLKMLS QIDRLEDLAK NPDKLTIRFA
     TLLEYVRNKY GIILNGNSNN MPMPATIDIK KRIITVDTKY YNFAYDKCYV YLDENSLSSD
     ILSLNADDAV DFENVSNSAF LVNDKTLYTY FSNTVLLSGN DKIHEISSRG ISAHILIYQA
     LMKHDISIPL TDIVNSLIGR NKQPIYEIIP RDKKTGKHGI IDIEKDIITH