ID   PAP1_FOWPV              Reviewed;         472 AA.
AC   P0DTA8; Q70H53; Q9J5B8;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   25-MAY-2022, entry version 8.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
DE   AltName: Full=VP55;
GN   Name=PAPL; OrderedLocusNames=FPV102;
OS   Fowlpox virus (FPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX   NCBI_TaxID=10261;
OH   NCBI_TaxID=7742; Vertebrata.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FP-9 / Isolate HP1-438 Munich;
RX   PubMed=14769888; DOI=10.1099/vir.0.19568-0;
RA   Skinner M.A., Laidlaw S.M.;
RT   "Comparison of the genome sequence of FP9, an attenuated, tissue culture-
RT   adapted European fowlpox virus, with those of virulent American and
RT   European viruses.";
RL   J. Gen. Virol. 85:305-322(2004).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AJ581527; CAE52643.1; -; Genomic_DNA.
DR   RefSeq; NP_039065.1; NC_002188.1.
DR   SMR; P0DTA8; -.
DR   GeneID; 1486650; -.
DR   KEGG; vg:1486650; -.
DR   Proteomes; UP000150838; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004652; F:polynucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1270.320; -; 1.
DR   Gene3D; 3.30.460.60; -; 1.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; Pox_polyA_pol_nucTrfase.
DR   InterPro; IPR038419; Pox_polyA_pol_nucTrfase_sf.
DR   InterPro; IPR004976; Poxviridae_polyA_pol_cat.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; SSF160957; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..472
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000448407"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        196
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   472 AA;  56081 MW;  ADDD6F39EC84DC22 CRC64;
     MERSRQVYYI INEYLGRHPS STEYQVLKHQ VEKISKINNF NKETFFFLLK KNKNKFFKDL
     ELSDDLLKKR IDEYFSKQKH AKRLGNLFAI MELQKILISS FTKTIGILTT KVPEYYHSTI
     KLEYSSMEKI ADDILDSYNV VEPSKEVKGR HKVSDLVGHV YKIMEEYLRR HSNSCLCYGS
     YSLHFLNNKI EYGDIDVLQT NARTFLINIA FLIKFITGRR IVLLKVPFLK NYVIMHDEET
     NHVMDTFNIR EKTMNMIPKI MIDNMYIVDP CIQLLNMIKM LSQIDRLEEL QAKFEKLSVR
     LGTLLEYTRY RYSIPLDSES ILEVRAKLDK DKRKITVDFK KYKLNYIKCY FYLDEVELKK
     FISKNSGLDE YEDFEAVTNS EYAIRNKTMY TYFSNTALMR SENEIHPITI NALTSHALLY
     HVITRKFYDD LLGDLVRSLM IVEKVPVFKI IPRDKKQGRH TIIDIEKDII FH