ID   PAP1_MYXVL              Reviewed;         470 AA.
AC   Q9Q8R9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   29-SEP-2021, entry version 72.
DE   RecName: Full=Poly(A) polymerase catalytic subunit;
DE            EC=2.7.7.19;
DE   AltName: Full=Poly(A) polymerase large subunit;
DE            Short=PAP-L;
GN   Name=PAPL; OrderedLocusNames=m027L;
OS   Myxoma virus (strain Lausanne) (MYXV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Leporipoxvirus.
OX   NCBI_TaxID=31530;
OH   NCBI_TaxID=9986; Oryctolagus cuniculus (Rabbit).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10562494; DOI=10.1006/viro.1999.0001;
RA   Cameron C., Hota-Mitchell S., Chen L., Barrett J.W., Cao J.-X.,
RA   Macaulay C., Willer D.O., Evans D.H., McFadden G.;
RT   "The complete DNA sequence of myxoma virus.";
RL   Virology 264:298-318(1999).
CC   -!- FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide;
CC         Xref=Rhea:RHEA:11332, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17347,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:140395,
CC         ChEBI:CHEBI:173115; EC=2.7.7.19;
CC   -!- SUBUNIT: Heterodimer of a large (catalytic) subunit and a small
CC       (regulatory) subunit. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae poly(A) polymerase catalytic
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AF170726; AAF14915.1; -; Genomic_DNA.
DR   RefSeq; NP_051741.1; NC_001132.2.
DR   SMR; Q9Q8R9; -.
DR   GeneID; 932202; -.
DR   KEGG; vg:932202; -.
DR   Proteomes; UP000000867; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004652; F:polynucleotide adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1270.320; -; 1.
DR   Gene3D; 3.30.460.60; -; 1.
DR   InterPro; IPR037265; PolyA_pol_cat_sf.
DR   InterPro; IPR024231; Pox_polyA_pol_nucTrfase.
DR   InterPro; IPR038419; Pox_polyA_pol_nucTrfase_sf.
DR   InterPro; IPR004976; Poxviridae_polyA_pol_cat.
DR   InterPro; IPR024397; Poxvirus_polyA_pol_cat_C.
DR   InterPro; IPR024398; Poxvirus_polyA_pol_cat_N.
DR   InterPro; IPR038337; Poxvirus_polyA_pol_cat_N_sf.
DR   Pfam; PF03296; Pox_polyA_pol; 1.
DR   Pfam; PF12629; Pox_polyA_pol_C; 1.
DR   Pfam; PF12630; Pox_polyA_pol_N; 1.
DR   PIRSF; PIRSF015693; VAC-48L_nuct; 1.
DR   SUPFAM; SSF160957; SSF160957; 1.
PE   3: Inferred from homology;
KW   ATP-binding; mRNA processing; Nucleotide-binding; Reference proteome;
KW   Transcription; Transferase.
FT   CHAIN           1..470
FT                   /note="Poly(A) polymerase catalytic subunit"
FT                   /id="PRO_0000308936"
FT   ACT_SITE        192
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        194
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   470 AA;  53836 MW;  65A8F42653A85D0F CRC64;
     MNARIAELLH NYLGRPPSLS EYHMLKLQHR NIQKIIAFNK DIFISLIKKN KKKFFSDIDL
     TSSEIKTSVL SYFSKQRDTY SIGKLYTIIE LQTILVSTYT DVLGVLTLKG PDMFPSSTRY
     DIKSIKQIAT SALHAMNVAV LSDKVMGRHN VSPLVSNVNA LMEEYLRRHN KNCICYGSYS
     LHLLNPEVKY GDIDILQTNS RTFLIDLAFL IKFITGSNVI LLKVPYLKNY MVLKDKDDNH
     IIDSFNIRQE TMQVIPKVLI DNIYIVDPAL QLMSMFKMFS QIDRLEDLAR NPEKLTVRLA
     TLMEYVRVKY GVILNGESNH MPMKGVLDKD KRIIVMDTSG YNFSFKKCFV YMDESSLSSD
     ILDLNADDAV DFENVSNSAY LVKGDVLYTY FSNTILLSDP DTIHEISNKA MSAHILIYQI
     LTGNDIRQPL SDLVNSLMYN EKVLIHEVIP RDKKTGKHGI IDIEKDIITH