ID   PAP1_PARMA              Reviewed;          10 AA.
AC   P81863;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Pardaxin-1;
DE   AltName: Full=Pardaxin I;
DE            Short=PXI;
DE   Flags: Fragment;
OS   Pardachirus marmoratus (Finless sole) (Achirus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Soleidae; Pardachirus.
OX   NCBI_TaxID=31087;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Skin secretion;
RX   PubMed=3782138; DOI=10.1016/s0021-9258(18)66622-0;
RA   Lazarovici P., Primor N., Loew L.M.;
RT   "Purification and pore-forming activity of two hydrophobic polypeptides
RT   from the secretion of the Red sea moses sole (Pardachirus marmoratus).";
RL   J. Biol. Chem. 261:16704-16713(1986).
CC   -!- FUNCTION: Exhibits unusual shark repellent and surfactant properties.
CC       Forms voltage-dependent, ion-permeable channels in membranes. At high
CC       concentration causes cell membrane lysis. Shown to be 5-10 times more
CC       toxic, cytolytic and active in membrane pore formation than pardaxin-2.
CC   -!- SUBUNIT: Monomer. In aqueous solution exists as a tetramer.
CC   -!- SUBCELLULAR LOCATION: Secreted. Target cell membrane. Note=Forms a
CC       helical membrane channel in the prey.
CC   -!- SIMILARITY: Belongs to the pardaxin family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion transport; Membrane; Secreted;
KW   Target cell membrane; Target membrane; Toxin; Transmembrane; Transport.
FT   PEPTIDE         1..>10
FT                   /note="Pardaxin-1"
FT                   /id="PRO_0000045112"
FT   NON_TER         10
SQ   SEQUENCE   10 AA;  1063 MW;  D399C36760572DD9 CRC64;
     GFFALIPGIE