ID   ASND1_CHICK             Reviewed;         636 AA.
AC   Q5ZJN0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Asparagine synthetase domain-containing protein 1;
GN   Name=ASNSD1; ORFNames=RCJMB04_16p18;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
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DR   EMBL; AJ720404; CAG32063.1; -; mRNA.
DR   RefSeq; NP_001006509.1; NM_001006509.1.
DR   AlphaFoldDB; Q5ZJN0; -.
DR   STRING; 9031.ENSGALP00000003773; -.
DR   PaxDb; Q5ZJN0; -.
DR   GeneID; 423983; -.
DR   KEGG; gga:423983; -.
DR   CTD; 54529; -.
DR   VEuPathDB; HostDB:geneid_423983; -.
DR   eggNOG; KOG0573; Eukaryota.
DR   InParanoid; Q5ZJN0; -.
DR   OrthoDB; 83779at2759; -.
DR   PhylomeDB; Q5ZJN0; -.
DR   PRO; PR:Q5ZJN0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0004066; F:asparagine synthase (glutamine-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0006529; P:asparagine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01991; Asn_Synthase_B_C; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR001962; Asn_synthase.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF00733; Asn_synthase; 1.
DR   Pfam; PF13537; GATase_7; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Asparagine biosynthesis;
KW   Glutamine amidotransferase; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..636
FT                   /note="Asparagine synthetase domain-containing protein 1"
FT                   /id="PRO_0000324763"
FT   DOMAIN          2..187
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
FT   DOMAIN          291..607
FT                   /note="Asparagine synthetase"
FT   ACT_SITE        2
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
SQ   SEQUENCE   636 AA;  71393 MW;  7788961D2B2F23B3 CRC64;
     MCGICCVVAL SSQHTICDYF SKDLHCHLRR RGPDSSQQLI KTVSEPSYEC FFSGHVLHLR
     GLMTPQPLED VNNNIFFWNG EIFNGVHVGD SENDTEVMFR HLALCSSEAD ILSLFSSLRG
     PWSFIYYQAS GHSLWFGRDY FGRRSLLWQL SNVSDGAFCL TSVSVNSESC NQCQEVPASG
     IFKMDLRDCA TTKSLSLTLF PWKYKCTEKN EEEIFIDVLD QVSKDLPNHI TVVMNESKLC
     LSAPVIPLNR TISEASVEHV SSDSSKTSSV VSLETLQGYL AVEHKRKVVH QFIDVLDEAV
     KRRVLLLRRG EDEGTGQVQG VSPRKAHVAV LFSGGVDSMV IAALADRHVP LEEPIDLLNV
     AFMTKEQTKR TGTTKNCIRQ EMKLDLHRGE ENHKDLDAKM GDDLSCFDVP DRITGRAGLK
     ELEALNPSRT WNFVEINVTL KELKEMRRRF INHLIYPLDT VLDDSIGCAI WFASRGEGYI
     NKQGEMKPYK SPAKVVLTGI GADEQLAGYS RHRICFRKCG PEGLNKELEM ELGRISSRNL
     GRDDRIIGDH GKEARFPFID EDVVSFLNSL PISEKADLTL PRGVGEKLIL RLGAKELGLE
     AASILPKRAV QFGSRIAKLE SNNEKAYHTC SRLKLF