ID   PAP5_PARMA              Reviewed;          33 AA.
AC   P81862;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Pardaxin P-5;
DE            Short=Pardaxin P5;
DE   AltName: Full=Pardaxin Pa5;
OS   Pardachirus marmoratus (Finless sole) (Achirus marmoratus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Soleidae; Pardachirus.
OX   NCBI_TaxID=31087;
RN   [1]
RP   PROTEIN SEQUENCE, CHARACTERIZATION, AND SYNTHESIS.
RC   TISSUE=Skin secretion;
RX   PubMed=9762902; DOI=10.1016/s0014-5793(98)01057-6;
RA   Adermann K., Raida M., Paul Y., Abu-Raya S., Bloch-Shilderman E.,
RA   Lazarovici P., Hochman J., Wellhoner H.;
RT   "Isolation, characterization and synthesis of a novel paradaxin isoform.";
RL   FEBS Lett. 435:173-177(1998).
CC   -!- FUNCTION: Exhibits unusual shark repellent and surfactant properties.
CC       Forms voltage-dependent, ion-permeable channels in membranes. At high
CC       concentration causes cell membrane lysis.
CC   -!- SUBUNIT: Monomer. In aqueous solution exists as a tetramer (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Target cell membrane. Note=Forms a
CC       helical membrane channel in the prey.
CC   -!- DOMAIN: Consists of a C-terminal hydrophilic region and a predominantly
CC       hydrophobic remainder.
CC   -!- SIMILARITY: Belongs to the pardaxin family. {ECO:0000305}.
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DR   AlphaFoldDB; P81862; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR009990; Pardaxin.
DR   Pfam; PF07425; Pardaxin; 1.
DR   PIRSF; PIRSF037561; Pardaxin; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion transport; Membrane; Secreted;
KW   Target cell membrane; Target membrane; Toxin; Transmembrane; Transport.
FT   PEPTIDE         1..33
FT                   /note="Pardaxin P-5"
FT                   /id="PRO_0000044786"
SQ   SEQUENCE   33 AA;  3382 MW;  5ABFFBBA16FC910D CRC64;
     GFFALIPKII SSPLFKTLLS AVGSALSSSG DQE