ID   PAPAS_HUMAN             Reviewed;         102 AA.
AC   Q5QFB9;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Protein PAPPAS;
DE   AltName: Full=DIPLA1 antisense RNA 1;
DE   AltName: Full=DIPLA1 antisense gene protein 1;
DE   AltName: Full=DIPLA1-antisense expressed;
DE   AltName: Full=PAPPAS antisense RNA 1;
DE   AltName: Full=PAPPAS antisense gene protein 1;
DE   AltName: Full=PAPPAS-antisense expressed;
GN   Name=PAPPA-AS1; Synonyms=DIPAS, PAPPAS;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC   TISSUE=Placenta;
RX   PubMed=15656990; DOI=10.1016/j.gene.2004.10.004;
RA   Garcia J., Castrillo J.L.;
RT   "Identification of two novel human genes, DIPLA1 and DIPAS, expressed in
RT   placenta tissue.";
RL   Gene 344:241-250(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in placenta with lower expression in
CC       brain, kidney and testis. {ECO:0000269|PubMed:15656990}.
CC   -!- CAUTION: Product of a dubious CDS prediction. May be a non-coding RNA.
CC       {ECO:0000305}.
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DR   EMBL; AY623011; AAV41519.1; -; mRNA.
DR   EMBL; AL137024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5QFB9; -.
DR   BioMuta; HGNC:35152; -.
DR   PaxDb; Q5QFB9; -.
DR   PRIDE; Q5QFB9; -.
DR   GeneCards; PAPPA-AS1; -.
DR   HGNC; HGNC:35152; PAPPA-AS1.
DR   MIM; 610689; gene.
DR   neXtProt; NX_Q5QFB9; -.
DR   InParanoid; Q5QFB9; -.
DR   PhylomeDB; Q5QFB9; -.
DR   PathwayCommons; Q5QFB9; -.
DR   ChiTaRS; PAPPA-AS1; human.
DR   Pharos; Q5QFB9; Tdark.
DR   PRO; PR:Q5QFB9; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q5QFB9; protein.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   5: Uncertain;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..102
FT                   /note="Protein PAPPAS"
FT                   /id="PRO_0000314006"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   102 AA;  12196 MW;  D3A5F7E7F4BB81AC CRC64;
     MRYGFVRKKH RGLFLTTVAA LPIWNPISEF VKWYKSHKLS QHCIRICGHL CQKHLDMFLS
     VIGQRWPIDV FSSVFDHQVS AIGSDIIWWF LKLFLVSFFF FF