ID   PAPB_ECOLX              Reviewed;         104 AA.
AC   P04744;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Major pilu subunit operon regulatory protein PapB;
GN   Name=papB;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700336 / J96 / UPEC;
RX   PubMed=2868893; DOI=10.1002/j.1460-2075.1985.tb04162.x;
RA   Baga M., Goeransson M., Normark S., Uhlin B.E.;
RT   "Transcriptional activation of a pap pilus virulence operon from
RT   uropathogenic Escherichia coli.";
RL   EMBO J. 4:3887-3893(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700336 / J96 / UPEC;
RX   PubMed=1357526; DOI=10.1111/j.1365-2958.1992.tb01399.x;
RA   Marklund B.-I., Tennent J.M., Garcia E., Hamers A., Baga M., Lindberg F.,
RA   Gaastra W., Normark S.;
RT   "Horizontal gene transfer of the Escherichia coli pap and prs pili operons
RT   as a mechanism for the development of tissue-specific adhesive
RT   properties.";
RL   Mol. Microbiol. 6:2225-2242(1992).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=2568258; DOI=10.1002/j.1460-2075.1989.tb03501.x;
RA   Forsman K., Goeransson M., Uhlin B.E.;
RT   "Autoregulation and multiple DNA interactions by a transcriptional
RT   regulatory protein in E. coli pili biogenesis.";
RL   EMBO J. 8:1271-1277(1989).
CC   -!- FUNCTION: May act as both positive and negative regulator of pap
CC       transcription. Might positively regulate levels of papI and/or mbf. Its
CC       autoregulatory mode of action involves differential binding to separate
CC       sites.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
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DR   EMBL; X03391; CAA27125.1; -; Genomic_DNA.
DR   EMBL; X61239; CAA43561.1; -; Genomic_DNA.
DR   EMBL; X55249; CAA38989.1; -; Genomic_DNA.
DR   EMBL; M63747; AAA24287.1; -; Genomic_DNA.
DR   PIR; B25121; RGECPB.
DR   RefSeq; WP_000930062.1; NZ_WWEL01000003.1.
DR   AlphaFoldDB; P04744; -.
DR   SMR; P04744; -.
DR   OMA; WLLVEIS; -.
DR   OrthoDB; 1819912at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR004356; Adhesin_operon_reg_prot.
DR   Pfam; PF03333; PapB; 1.
DR   PRINTS; PR01554; FIMREGULATRY.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; Fimbrium biogenesis; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..104
FT                   /note="Major pilu subunit operon regulatory protein PapB"
FT                   /id="PRO_0000058230"
SQ   SEQUENCE   104 AA;  11695 MW;  90CA7B9E72A63A22 CRC64;
     MAHHEVISRS GNAFLLNIRE SVLLPGSMSE MHFFLLIGIS SIHSDRVILA MKDYLVGGHS
     RKEVCEKYQM NNGYFSTTLG RLIRLNALAA RLAPYYTDES SAFD