ID   PAPB_STRPR              Reviewed;         129 AA.
AC   P72541;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=4-amino-4-deoxychorismate mutase {ECO:0000305};
DE            Short=ADC mutase {ECO:0000305};
DE            EC=5.4.99.67 {ECO:0000305|PubMed:9044253};
GN   Name=papB {ECO:0000303|PubMed:9044253};
OS   Streptomyces pristinaespiralis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=38300;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC   STRAIN=SP92;
RX   PubMed=9044253; DOI=10.1046/j.1365-2958.1997.2031574.x;
RA   Blanc V., Gil P., Bamas-Jacques N., Lorenzon S., Zagorec M.,
RA   Schleuniger J., Bisch D., Blanche F., Debussche L., Crouzet J., Thibaut D.;
RT   "Identification and analysis of genes from Streptomyces pristinaespiralis
RT   encoding enzymes involved in the biosynthesis of the 4-dimethylamino-L-
RT   phenylalanine precursor of pristinamycin I.";
RL   Mol. Microbiol. 23:191-202(1997).
CC   -!- FUNCTION: Involved in pristinamycin I biosynthesis (PubMed:9044253).
CC       Probably catalyzes the conversion of 4-amino-4-deoxychorismate to 4-
CC       amino-4-deoxyprephenate (Probable). {ECO:0000269|PubMed:9044253,
CC       ECO:0000305|PubMed:9044253}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate;
CC         Xref=Rhea:RHEA:59376, ChEBI:CHEBI:58406, ChEBI:CHEBI:143070;
CC         EC=5.4.99.67; Evidence={ECO:0000305|PubMed:9044253};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59377;
CC         Evidence={ECO:0000305|PubMed:9044253};
CC   -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000269|PubMed:9044253}.
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DR   EMBL; U60417; AAC44868.1; -; Genomic_DNA.
DR   SMR; P72541; -.
DR   BRENDA; 5.4.99.67; 12737.
DR   GO; GO:0016835; F:carbon-oxygen lyase activity; IEA:InterPro.
DR   GO; GO:0004106; F:chorismate mutase activity; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0046417; P:chorismate metabolic process; IEA:InterPro.
DR   GO; GO:0009697; P:salicylic acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.20.59.10; -; 1.
DR   InterPro; IPR036263; Chorismate_II_sf.
DR   InterPro; IPR036979; CM_dom_sf.
DR   InterPro; IPR002701; CM_II_prokaryot.
DR   InterPro; IPR008241; Isochorismate_pyruvate-lyase.
DR   Pfam; PF01817; CM_2; 1.
DR   SMART; SM00830; CM_2; 1.
DR   SUPFAM; SSF48600; SSF48600; 1.
DR   TIGRFAMs; TIGR01803; CM-like; 1.
DR   PROSITE; PS51168; CHORISMATE_MUT_2; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Isomerase.
FT   CHAIN           1..129
FT                   /note="4-amino-4-deoxychorismate mutase"
FT                   /id="PRO_0000453962"
FT   DOMAIN          16..107
FT                   /note="Chorismate mutase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00515"
SQ   SEQUENCE   129 AA;  13666 MW;  1BEB0FC2F06CEAD4 CRC64;
     MTPPAIPAAP PATGPAAATD PLDALRARLD AADAALLDAV RTRLDICLRI GEYKRLHQVP
     MMQPHRIAQV HANAARYAAD HGIDPAFLRT LYDTIITETC RLEDEWIASG GAPVPTPVHA
     SASARGAVS