ID   ASND1_MACFA             Reviewed;         643 AA.
AC   Q4R5D4; Q4R4W1;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Asparagine synthetase domain-containing protein 1;
GN   Name=ASNSD1; ORFNames=QnpA-19512, QtrA-13028;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex, and Temporal cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB169610; BAE01691.1; -; mRNA.
DR   EMBL; AB169783; BAE01864.1; -; mRNA.
DR   AlphaFoldDB; Q4R5D4; -.
DR   SMR; Q4R5D4; -.
DR   STRING; 9541.XP_005573760.1; -.
DR   eggNOG; KOG0573; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0004066; F:asparagine synthase (glutamine-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0006529; P:asparagine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01991; Asn_Synthase_B_C; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   Gene3D; 3.60.20.10; -; 1.
DR   InterPro; IPR001962; Asn_synthase.
DR   InterPro; IPR017932; GATase_2_dom.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   Pfam; PF00733; Asn_synthase; 1.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Asparagine biosynthesis;
KW   Glutamine amidotransferase; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..643
FT                   /note="Asparagine synthetase domain-containing protein 1"
FT                   /id="PRO_0000324761"
FT   DOMAIN          2..184
FT                   /note="Glutamine amidotransferase type-2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
FT   DOMAIN          285..601
FT                   /note="Asparagine synthetase"
FT   REGION          367..404
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        2
FT                   /note="For GATase activity"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        20
FT                   /note="R -> K (in Ref. 1; BAE01864)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="Q -> H (in Ref. 1; BAE01864)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        610
FT                   /note="I -> V (in Ref. 1; BAE01864)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   643 AA;  72181 MW;  B78253BD76C1459E CRC64;
     MCGICCSVNF SAEHFSQDLR EDLLYNLKQR GPNSSKQLFK SDVNYQCLFS GHVLHLRGVL
     TTQPVEDERG NVFLWNGEIF SGIKVEAEEN DTQILFNYLS SCKNESEILS LFSEVQGPWS
     FIYYQASSHY LWFGRDFFGR RSLLWHFSNL GKSFCLSSVG TQTSGLANQW QEVPASGLFR
     IDLKSTAISR CIILQLYPWK YISRENIIEE NVNSLSQISA DLPAFVSVVA NEAKLYLEKP
     VVPLNMMLPQ AALETHCSNI SNVPPTRETL QVFLTDVHIK EVIQQFIDVL SVAVKKRVLC
     LPRGENLTAN EVSKMCDRKA NVAILFSGGI DSMVIATLAD RHIPLDEPID LLNVAFIAEE
     KTMPTSFNKE RNKQKNKCEI SSEEFSKDDA AADDDSPDKH VSVPDRITGR AGLKELKAVS
     PSRIWNFVEI NVSMEELQKL RRTRICHLIQ PLDTVLDDSI GCAVWFASRG IGWLVAQDGV
     KSYQSSAKVV LTGIGADEQL AGYSRHRVRF QSHGLEGLNK EIMMELGRIS SRNLGRDDRV
     IGDHGKEARF PFLDENVVSF LNSLPIWEKA NLTLPRGIGE KLLLRLAAVE LGLTASALLP
     KRAMQFGSRI AKMEKNNEKA SDKCGRLQII SLENLSIEKE TKL