ID   PAPE_TITSE              Reviewed;          88 AA.
AC   P86821;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 2.
DT   03-AUG-2022, entry version 13.
DE   RecName: Full=Pape peptide {ECO:0000250|UniProtKB:P0C8W6, ECO:0000303|PubMed:18718845};
DE   Flags: Precursor;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   DOI=10.4236/ojgen.2012.24027;
RA   Alvarenga E.R., Mendes T.M., Magalhaes B.F., Siqueira F.F., Dantas A.E.,
RA   Barroca T.M., Horta C.C., Kalapothakis E.;
RT   "Transcriptome analysis of the Tityus serrulatus scorpion venom gland.";
RL   O. J. Gen. 2:210-220(2012).
RN   [2]
RP   PROTEIN SEQUENCE OF 46-83, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=18718845; DOI=10.1016/j.toxicon.2008.07.010;
RA   Rates B., Ferraz K.K., Borges M.H., Richardson M., De Lima M.E.,
RA   Pimenta A.M.;
RT   "Tityus serrulatus venom peptidomics: assessing venom peptide diversity.";
RL   Toxicon 52:611-618(2008).
RN   [3]
RP   PROTEIN SEQUENCE OF 46-65, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom {ECO:0000303|PubMed:25199494};
RX   PubMed=25199494; DOI=10.1016/j.toxicon.2014.08.064;
RA   Pucca M.B., Amorim F.G., Cerni F.A., Bordon K.C.F., Cardoso I.A.,
RA   Anjolette F.A., Arantes E.C.;
RT   "Influence of post-starvation extraction time and prey-specific diet in
RT   Tityus serrulatus scorpion venom composition and hyaluronidase activity.";
RL   Toxicon 90:326-336(2014).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18718845,
CC       ECO:0000269|PubMed:25199494}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:25199494}.
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DR   AlphaFoldDB; P86821; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..45
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000455733"
FT   CHAIN           46..83
FT                   /note="Pape peptide"
FT                   /id="PRO_0000401165"
FT   REPEAT          57..60
FT                   /note="PAPE 1"
FT                   /evidence="ECO:0000305"
FT   REPEAT          61..64
FT                   /note="PAPE 2"
FT                   /evidence="ECO:0000305"
FT   REPEAT          65..68
FT                   /note="PAPE 3"
FT                   /evidence="ECO:0000305"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..27
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   88 AA;  9838 MW;  4F80F6E27E761530 CRC64;
     MNRKTLLVIF FVTLLIAEEV NSFRLGGFLK KIWRSKLVKR LRSKGKQLLK EALAPEPAPE
     PAPEPAPEAA PEAAPEPAAA APERRRRR