ID   PAPF_ECOLX              Reviewed;         167 AA.
AC   P08408;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Fimbrial adapter PapF;
DE   Flags: Precursor;
GN   Name=papF;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700336 / J96 / UPEC;
RX   PubMed=2869489; DOI=10.1073/pnas.83.6.1891;
RA   Lindberg F., Lund B., Normark S.;
RT   "Gene products specifying adhesion of uropathogenic Escherichia coli are
RT   minor components of pili.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:1891-1895(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700336 / J96 / UPEC;
RX   PubMed=2895103; DOI=10.1128/jb.170.4.1887-1894.1988;
RA   Lund B., Lindberg F., Normark S.;
RT   "Structure and antigenic properties of the tip-located P pilus proteins of
RT   uropathogenic Escherichia coli.";
RL   J. Bacteriol. 170:1887-1894(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700336 / J96 / UPEC;
RX   PubMed=1357526; DOI=10.1111/j.1365-2958.1992.tb01399.x;
RA   Marklund B.-I., Tennent J.M., Garcia E., Hamers A., Baga M., Lindberg F.,
RA   Gaastra W., Normark S.;
RT   "Horizontal gene transfer of the Escherichia coli pap and prs pili operons
RT   as a mechanism for the development of tissue-specific adhesive
RT   properties.";
RL   Mol. Microbiol. 6:2225-2242(1992).
RN   [4]
RP   FUNCTION.
RX   PubMed=8096174; DOI=10.1002/j.1460-2075.1993.tb05724.x;
RA   Jacob-Dubuisson F., Heuser J., Dodson K., Normark S., Hultgren S.;
RT   "Initiation of assembly and association of the structural elements of a
RT   bacterial pilus depend on two specialized tip proteins.";
RL   EMBO J. 12:837-847(1993).
RN   [5]
RP   REVIEW.
RX   PubMed=10049807; DOI=10.1006/jsbi.1998.4049;
RA   Hung D.L., Hultgren S.J.;
RT   "Pilus biogenesis via the chaperone/usher pathway: an integration of
RT   structure and function.";
RL   J. Struct. Biol. 124:201-220(1998).
CC   -!- FUNCTION: Adapter that links the PapG adhesin to the distal end of the
CC       tip fibrillum. PapF is required for the correct presentation of the
CC       adhesin at the distal end of the tip fibrillum. Pili are polar
CC       filaments radiating from the surface of the bacterium to a length of
CC       0.5-1.5 micrometers and numbering 100-300 per cell, and enable bacteria
CC       to colonize the epithelium of specific host organs.
CC       {ECO:0000269|PubMed:8096174}.
CC   -!- INTERACTION:
CC       P08408; P15319: papD; NbExp=5; IntAct=EBI-15725486, EBI-1034993;
CC   -!- SUBCELLULAR LOCATION: Secreted. Fimbrium. Note=At the tip of the pili.
CC   -!- MISCELLANEOUS: Strains of E.coli that cause infection of the human
CC       urinary tract produce pap-pili which are hair-like appendages
CC       consisting of about 1000 helically arranged subunits of the protein
CC       PapA. These pili mediate binding to digalactoside-containing
CC       glycolipids present on the epithelial cells which line the urinary
CC       tract.
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DR   EMBL; M13239; AAA24281.1; -; Genomic_DNA.
DR   EMBL; M20146; AAA24289.1; -; Genomic_DNA.
DR   EMBL; X61239; CAA43569.1; -; Genomic_DNA.
DR   PIR; B25134; YQECPF.
DR   AlphaFoldDB; P08408; -.
DR   SMR; P08408; -.
DR   DIP; DIP-46336N; -.
DR   IntAct; P08408; 3.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   InterPro; IPR005430; P_pili_tip_PapF.
DR   Pfam; PF00419; Fimbrial; 1.
DR   PRINTS; PR01613; FIMBRIALPAPF.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion; Fimbrium; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..167
FT                   /note="Fimbrial adapter PapF"
FT                   /id="PRO_0000022004"
SQ   SEQUENCE   167 AA;  17625 MW;  6D0CCB78BA283153 CRC64;
     MIRLSLFISL LLTSVAVLAD VQINIRGNVY IPPCTINNGQ NIVVDFGNIN PEHVDNSRGE
     VTKTISISCP YKSGSLWIKV TGNTMGGGQN NVLATNITHF GIALYQGKGM STPLILGNGS
     GNGYGVTAGL DTARSTFTFT SVPFRNGSGI LNGGDFQTTA SMSMIYN