ASND1_SCHPO
ID ASND1_SCHPO Reviewed; 548 AA.
AC O74397;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Asparagine synthetase domain-containing protein C4F6.11c;
GN ORFNames=SPBC4F6.11c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; CU329671; CAA20731.1; -; Genomic_DNA.
DR PIR; T40508; T40508.
DR RefSeq; NP_596111.1; NM_001022028.2.
DR AlphaFoldDB; O74397; -.
DR SMR; O74397; -.
DR BioGRID; 277384; 1.
DR STRING; 4896.SPBC4F6.11c.1; -.
DR iPTMnet; O74397; -.
DR MaxQB; O74397; -.
DR PaxDb; O74397; -.
DR EnsemblFungi; SPBC4F6.11c.1; SPBC4F6.11c.1:pep; SPBC4F6.11c.
DR GeneID; 2540867; -.
DR KEGG; spo:SPBC4F6.11c; -.
DR PomBase; SPBC4F6.11c; -.
DR VEuPathDB; FungiDB:SPBC4F6.11c; -.
DR eggNOG; KOG0573; Eukaryota.
DR HOGENOM; CLU_012368_2_0_1; -.
DR InParanoid; O74397; -.
DR OMA; CFDVPDR; -.
DR PhylomeDB; O74397; -.
DR PRO; PR:O74397; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0004066; F:asparagine synthase (glutamine-hydrolyzing) activity; ISM:PomBase.
DR GO; GO:0006529; P:asparagine biosynthetic process; ISM:PomBase.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01991; Asn_Synthase_B_C; 1.
DR Gene3D; 3.40.50.620; -; 1.
DR Gene3D; 3.60.20.10; -; 1.
DR InterPro; IPR001962; Asn_synthase.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR Pfam; PF00733; Asn_synthase; 1.
DR Pfam; PF13537; GATase_7; 1.
DR SUPFAM; SSF56235; SSF56235; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Asparagine biosynthesis; Cytoplasm;
KW Glutamine amidotransferase; Nucleus; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..548
FT /note="Asparagine synthetase domain-containing protein
FT C4F6.11c"
FT /id="PRO_0000314119"
FT DOMAIN 2..193
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
FT DOMAIN 239..519
FT /note="Asparagine synthetase"
FT ACT_SITE 2
FT /note="Nucleophile"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00609"
SQ SEQUENCE 548 AA; 62006 MW; C0C6DB4EA5FF39DD CRC64;
MCGILFALAE DRDNLLESPS FSALRKRIRA RGPDFFGKHK LNSGPWNLHF ESSVLHLRGP
SDHLTPQPHV DSFGNVLCWN GEIWQINHSD HHKFTLNRNE NDGAKLFELL NNNPGDIEKI
LGSIQGPFAF VYYQVRTNTL WWGRDRLGRR SLLYSLRDSN FVLSSVGNSS DFREVEPGFH
SVQVDLIPKI NFSKSLMQLE KTNPLPPVDE SFLMGSISSD TVDTLHTYLI KALQDRVLTI
PKLCSSNLDC SHYSRVCVLY SGGVDCGVLA RLMHDIVPNN ESIDLINVAF ENPRFTETYR
DRETGLLPDN FDAYDVCPDR QTGLQGWQEL ISVCPARKWN FVAINVPYTE VCEAQEIVKT
LIYPNDSVMD LSIGLAFYFA SQGRGVLLQN VDDIKLKHQL PSYTIKAKVL ISGLGADEQL
GGYMRHLRAF ERKGMAGLEE ELQLDIDRIP HRNLGRDDRV MSNQGKEVRY PFLDERLMAL
FSKMKTTDKM RLDLVGGDKL ILRELGRRLG CPLASQEKKR AIQFGSKAAK MTPGTGRTSG
RKKLEVCI
