ID   PAPK_ECOL6              Reviewed;         178 AA.
AC   P62533; P42190;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Fimbrial adapter PapK;
DE   Flags: Precursor;
GN   Name=papK; OrderedLocusNames=c3586;
GN   and
GN   Name=papK2; OrderedLocusNames=c5182;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Adapter that links the pilus rod to the base of the tip
CC       fibrillum. Regulates the length of the tip fibrillum and joins it to
CC       the pilus rod. Pili are polar filaments radiating from the surface of
CC       the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300
CC       per cell, and enable bacteria to colonize the epithelium of specific
CC       host organs (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Fimbrium {ECO:0000250}.
CC   -!- MISCELLANEOUS: Strains of E.coli that cause infection of the human
CC       urinary tract produce pap-pili which are hair-like appendages
CC       consisting of about 1000 helically arranged subunits of the protein
CC       PapA. These pili mediate binding to digalactoside-containing
CC       glycolipids present on the epithelial cells which line the urinary
CC       tract (By similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82034.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAN83604.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82034.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE014075; AAN83604.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000597713.1; NC_004431.1.
DR   AlphaFoldDB; P62533; -.
DR   SMR; P62533; -.
DR   IntAct; P62533; 1.
DR   MINT; P62533; -.
DR   STRING; 199310.c3586; -.
DR   EnsemblBacteria; AAN82034; AAN82034; c3586.
DR   EnsemblBacteria; AAN83604; AAN83604; c5182.
DR   KEGG; ecc:c3586; -.
DR   KEGG; ecc:c5182; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_088965_3_3_6; -.
DR   OMA; MMIKSTG; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   3: Inferred from homology;
KW   Fimbrium; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..178
FT                   /note="Fimbrial adapter PapK"
FT                   /id="PRO_0000022007"
SQ   SEQUENCE   178 AA;  18872 MW;  DABF3054B87CA8CB CRC64;
     MIKSTGALLL FAALSAGQAI ASDVAFRGNL LDRPCHVSGD SLNKHVVFKT RASRDFWYPP
     GRSPTESFVI RLENCHATAV GKIVTLTFKG TEEAALPGHL KVTGVNAGRL GIALLDTDGS
     SLLKPGTSHN KGQGEKVTGN SLELPFGAYV VATPEALRTK SVVPGDYEAT ATFELTYR