ID   PAP_HHV8P               Reviewed;         396 AA.
AC   F5HID2;
DT   16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   02-JUN-2021, entry version 30.
DE   RecName: Full=DNA polymerase processivity factor;
GN   Name=ORF59;
OS   Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's
OS   sarcoma-associated herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=868565;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10400794; DOI=10.1128/jvi.73.8.6953-6963.1999;
RA   Glenn M., Rainbow L., Aurade F., Davison A., Schulz T.F.;
RT   "Identification of a spliced gene from Kaposi's sarcoma-associated
RT   herpesvirus encoding a protein with similarities to latent membrane
RT   proteins 1 and 2A of Epstein-Barr virus.";
RL   J. Virol. 73:6953-6963(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16760382; DOI=10.1099/vir.0.81919-0;
RA   Rezaee S.A.R., Cunningham C., Davison A.J., Blackbourn D.J.;
RT   "Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.";
RL   J. Gen. Virol. 87:1781-1804(2006).
CC   -!- FUNCTION: Plays an essential role in the viral lytic DNA replication by
CC       acting as the polymerase accessory subunit. Stimulates the viral DNA
CC       polymerase activity and appears to function with it as a holoenzyme.
CC       Increases the processivity of the viral polymerase, probably by acting
CC       as a sliding clamp that prevents dissociation of the polymerase from
CC       the active template (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homooligomerizes and adopts an oligomeric ring-shaped
CC       structure composed of 6 subunits. Forms a complex with the DNA-binding
CC       protein, the DNA polymerase subunit, and the alkaline exonuclease (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000250}. Host nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae DNA polymerase accessory
CC       subunit family. {ECO:0000305}.
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DR   EMBL; AF148805; ABD28914.1; -; Genomic_DNA.
DR   RefSeq; YP_001129416.1; NC_009333.1.
DR   SMR; F5HID2; -.
DR   BioGRID; 1776995; 5.
DR   iPTMnet; F5HID2; -.
DR   PRIDE; F5HID2; -.
DR   DNASU; 4961492; -.
DR   GeneID; 4961492; -.
DR   KEGG; vg:4961492; -.
DR   Proteomes; UP000000942; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IDA:UniProtKB.
DR   InterPro; IPR007013; DNA_pol_proc_fac_herpes.
DR   Pfam; PF04929; Herpes_DNAp_acc; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Early protein; Host nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Virion; Virion tegument.
FT   CHAIN           1..396
FT                   /note="DNA polymerase processivity factor"
FT                   /id="PRO_0000423804"
FT   REGION          306..396
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  42378 MW;  826E60A83989D4F1 CRC64;
     MPVDFHYGVR VDVTLLSKIR RVNEHIKSAT KTGVVQVHGS ACTPTLSVLS SVGTAGVLGL
     RIKNALTPLV GHTEGSGDVS FSFRNTSVGS GFTHTRELFG ANVLDAGIAF YRKGEACDTG
     AQPQFVRTTI SYGDNLTSTV HKSVVDQKGI LPFHDRMEAG GRTTRLLLCG KTGAFLLKWL
     RQQKTKEDQT VTVSVSETLS IVTFSLGGVS KIIDFKPETK PVSGWDGLKG KKSVDVGVVH
     TDALSRVSLE SLIAALRLCK VPGWFTPGLI WHSNEILEVE GVPTGCQSGD VKLSVLLLEV
     NRSVSAEGGE SSQKVPDSIP DSRRQPELES PDSPPLTPVG PFGPLEDASE DAASVTSCPP
     AAPTKDSTKR PHKRRSDSSQ SRDRGKVPKT TFNPLI