ID   PAP_VZVO                Reviewed;         408 AA.
AC   Q4JQV9;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   23-FEB-2022, entry version 40.
DE   RecName: Full=DNA polymerase processivity factor;
DE   AltName: Full=DNA-binding gene 16 protein;
DE   AltName: Full=Polymerase accessory protein;
DE            Short=PAP;
GN   ORFNames=ORF16;
OS   Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=341980;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC   Oka varicella vaccine Biken (V-Oka-Biken);
RX   PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA   Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT   its parental virus.";
RL   J. Virol. 76:11447-11459(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC   Oka varicella vaccine Varivax (V-Oka-Merk);
RX   PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA   Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA   Vassilev V.;
RT   "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL   J. Virol. 82:11023-11044(2008).
CC   -!- FUNCTION: Plays an essential role in viral DNA replication by acting as
CC       the polymerase accessory subunit. Associates with the viral polymerase
CC       to increase its processivity and forms high-affinity direct
CC       interactions with DNA. Facilitates the origin-binding protein loading
CC       onto DNA thus increasing its ability to assemble into a functional
CC       complex capable of unwinding duplex DNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the DNA polymerase catalytic subunit. Interacts
CC       with the origin-binding protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae DNA polymerase processivity
CC       factor family. {ECO:0000305}.
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DR   EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; DQ008354; AAY57684.1; -; Genomic_DNA.
DR   EMBL; DQ008355; AAY57755.1; -; Genomic_DNA.
DR   SMR; Q4JQV9; -.
DR   IntAct; Q4JQV9; 18.
DR   MINT; Q4JQV9; -.
DR   Proteomes; UP000002603; Genome.
DR   Proteomes; UP000008504; Genome.
DR   Proteomes; UP000008505; Genome.
DR   Proteomes; UP000008506; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   InterPro; IPR003202; Herpes_UL42.
DR   Pfam; PF02282; Herpes_UL42; 2.
PE   3: Inferred from homology;
KW   DNA replication; DNA-binding; Host nucleus.
FT   CHAIN           1..408
FT                   /note="DNA polymerase processivity factor"
FT                   /id="PRO_0000385148"
FT   MOTIF           344..353
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   408 AA;  46060 MW;  DD770E6079581FF9 CRC64;
     MDLRSRTDDA LDMELHAGFD APEIARAVLT EKTLTGLISS ISPLVNRLRD SILIFSDEGL
     IIHCSLETEQ LYIPIPANMF DQYNWTGPRM VVLAATEGRS SLIDAFRHTK DPSTPTRLYF
     KFTGQPPERS IIQTMVWQRP GDCGPDDQVQ CYKQVVKREL ACYTMMFPNL TPDISICLKR
     DQFTRLQRLL KTFGFTTCFI LTATDMYIQT AGGGFISFNV SLDINGSKPT PYNLIRSITN
     SKRILNNVVY GSGSMREFGV LLETHSGFRS AVQNLKLTRD ETCYINFYLA LTNSPMVGLY
     IQRSAPVHSF FYATFLSPKD LKEKLTSMQL FANTESVKDE PPLKKRRNLL TKRNEKNTGN
     KMGGKLPETT WQEGIGIREY CVAPPVDPAG TLDYSELSRE SDVICTVK