PAQR3_MOUSE
ID PAQR3_MOUSE Reviewed; 311 AA.
AC Q6TCG8;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Progestin and adipoQ receptor family member 3 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member III;
DE AltName: Full=Raf kinase trapping to Golgi {ECO:0000303|PubMed:17724343};
DE Short=RKTG {ECO:0000303|PubMed:17724343};
GN Name=Paqr3 {ECO:0000312|MGI:MGI:2679683};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=17724343; DOI=10.1073/pnas.0701298104;
RA Feng L., Xie X., Ding Q., Luo X., He J., Fan F., Liu W., Wang Z., Chen Y.;
RT "Spatial regulation of Raf kinase signaling by RKTG.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:14348-14353(2007).
CC -!- FUNCTION: Functions as a spatial regulator of RAF1 kinase by
CC sequestrating it to the Golgi. {ECO:0000269|PubMed:17724343}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:17724343}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:17724343}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY424292; AAR08380.1; -; mRNA.
DR CCDS; CCDS19451.1; -.
DR RefSeq; NP_940814.1; NM_198422.2.
DR RefSeq; XP_006534937.1; XM_006534874.3.
DR RefSeq; XP_006534938.1; XM_006534875.3.
DR AlphaFoldDB; Q6TCG8; -.
DR SMR; Q6TCG8; -.
DR STRING; 10090.ENSMUSP00000108593; -.
DR iPTMnet; Q6TCG8; -.
DR PhosphoSitePlus; Q6TCG8; -.
DR MaxQB; Q6TCG8; -.
DR PaxDb; Q6TCG8; -.
DR PRIDE; Q6TCG8; -.
DR ProteomicsDB; 294008; -.
DR Antibodypedia; 55228; 53 antibodies from 10 providers.
DR DNASU; 231474; -.
DR Ensembl; ENSMUST00000069453; ENSMUSP00000069324; ENSMUSG00000055725.
DR Ensembl; ENSMUST00000112969; ENSMUSP00000108593; ENSMUSG00000055725.
DR GeneID; 231474; -.
DR KEGG; mmu:231474; -.
DR UCSC; uc008yfq.1; mouse.
DR CTD; 152559; -.
DR MGI; MGI:2679683; Paqr3.
DR VEuPathDB; HostDB:ENSMUSG00000055725; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000155291; -.
DR InParanoid; Q6TCG8; -.
DR OMA; CLESIFW; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q6TCG8; -.
DR TreeFam; TF313640; -.
DR Reactome; R-MMU-5675221; Negative regulation of MAPK pathway.
DR BioGRID-ORCS; 231474; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Paqr3; mouse.
DR PRO; PR:Q6TCG8; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q6TCG8; protein.
DR Bgee; ENSMUSG00000055725; Expressed in embryonic brain and 60 other tissues.
DR ExpressionAtlas; Q6TCG8; baseline and differential.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.
DR GO; GO:0010977; P:negative regulation of neuron projection development; ISO:MGI.
DR GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:MGI.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; ISO:MGI.
DR GO; GO:0006468; P:protein phosphorylation; IMP:MGI.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..311
FT /note="Progestin and adipoQ receptor family member 3"
FT /id="PRO_0000218847"
FT TOPO_DOM 1..70
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 92..104
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..172
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..235
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 257..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..311
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT REGION 61..71
FT /note="Golgi targeting"
FT /evidence="ECO:0000250"
FT REGION 299..303
FT /note="Golgi targeting"
FT /evidence="ECO:0000250"
SQ SEQUENCE 311 AA; 36212 MW; 8EEBFE70BDBA1299 CRC64;
MHQKLLKSAH YIELGSYQYW PVLVPRGIRL YTYEQIPVSL KDNPYITDGY RAYLPSRLCI
KSLFILSNET VNIWSHLLGF FLFFTLGIYD MTSVLPSASA SREDFVICSI CLFCFQVCML
CSVGYHLFSC HRSEKTCRRW MALDYAGISI GILGCYVSGV FYAFYCNNYW RQVYLITVLA
MILAVFFAQI HPSYLTQQWQ RLRPIIFCSV SGYGVIPTLH WVWLNGGVSA PIVQDFAPRV
IVMYVIALLA FLFYISKVPE RYFPGQLNYL GSSHQIWHVL AVVMLYWWHQ STVYVMQYRH
SKPCPDYVSH L
