PAQR4_HUMAN
ID PAQR4_HUMAN Reviewed; 273 AA.
AC Q8N4S7; A8K5Q8; D3DUA2; D3DUA3; Q8NAS6; Q96NW1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Progestin and adipoQ receptor family member 4 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member IV;
GN Name=PAQR4 {ECO:0000312|HGNC:HGNC:26386};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain, Neuroblastoma, and Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8N4S7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N4S7-2; Sequence=VSP_011481;
CC Name=3;
CC IsoId=Q8N4S7-3; Sequence=VSP_011482;
CC -!- TISSUE SPECIFICITY: Relatively widely expressed in a range of tissues.
CC {ECO:0000269|PubMed:16044242}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424282; AAR08370.1; -; mRNA.
DR EMBL; AK054564; BAB70758.1; -; mRNA.
DR EMBL; AK092173; BAC03821.1; -; mRNA.
DR EMBL; AK291373; BAF84062.1; -; mRNA.
DR EMBL; CH471112; EAW85441.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85442.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85443.1; -; Genomic_DNA.
DR EMBL; CH471112; EAW85444.1; -; Genomic_DNA.
DR EMBL; BC033703; AAH33703.1; -; mRNA.
DR CCDS; CCDS10485.1; -. [Q8N4S7-1]
DR CCDS; CCDS66911.1; -. [Q8N4S7-2]
DR RefSeq; NP_001271440.1; NM_001284511.1. [Q8N4S7-2]
DR RefSeq; NP_001271441.1; NM_001284512.1.
DR RefSeq; NP_689554.2; NM_152341.4. [Q8N4S7-1]
DR AlphaFoldDB; Q8N4S7; -.
DR SMR; Q8N4S7; -.
DR BioGRID; 125857; 9.
DR IntAct; Q8N4S7; 1.
DR STRING; 9606.ENSP00000321804; -.
DR iPTMnet; Q8N4S7; -.
DR PhosphoSitePlus; Q8N4S7; -.
DR BioMuta; PAQR4; -.
DR DMDM; 146345478; -.
DR EPD; Q8N4S7; -.
DR jPOST; Q8N4S7; -.
DR MassIVE; Q8N4S7; -.
DR MaxQB; Q8N4S7; -.
DR PaxDb; Q8N4S7; -.
DR PeptideAtlas; Q8N4S7; -.
DR PRIDE; Q8N4S7; -.
DR ProteomicsDB; 71962; -. [Q8N4S7-1]
DR ProteomicsDB; 71963; -. [Q8N4S7-2]
DR ProteomicsDB; 71964; -. [Q8N4S7-3]
DR Antibodypedia; 42629; 30 antibodies from 13 providers.
DR DNASU; 124222; -.
DR Ensembl; ENST00000293978.12; ENSP00000293978.8; ENSG00000162073.14. [Q8N4S7-2]
DR Ensembl; ENST00000318782.9; ENSP00000321804.8; ENSG00000162073.14. [Q8N4S7-1]
DR GeneID; 124222; -.
DR KEGG; hsa:124222; -.
DR MANE-Select; ENST00000318782.9; ENSP00000321804.8; NM_152341.5; NP_689554.2.
DR UCSC; uc002csj.5; human. [Q8N4S7-1]
DR CTD; 124222; -.
DR DisGeNET; 124222; -.
DR GeneCards; PAQR4; -.
DR HGNC; HGNC:26386; PAQR4.
DR HPA; ENSG00000162073; Tissue enhanced (brain, retina).
DR MIM; 614578; gene.
DR neXtProt; NX_Q8N4S7; -.
DR OpenTargets; ENSG00000162073; -.
DR PharmGKB; PA134945614; -.
DR VEuPathDB; HostDB:ENSG00000162073; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000157978; -.
DR HOGENOM; CLU_023075_0_1_1; -.
DR InParanoid; Q8N4S7; -.
DR OMA; HHACPPD; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q8N4S7; -.
DR TreeFam; TF323692; -.
DR PathwayCommons; Q8N4S7; -.
DR SignaLink; Q8N4S7; -.
DR BioGRID-ORCS; 124222; 24 hits in 1082 CRISPR screens.
DR ChiTaRS; PAQR4; human.
DR GenomeRNAi; 124222; -.
DR Pharos; Q8N4S7; Tdark.
DR PRO; PR:Q8N4S7; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q8N4S7; protein.
DR Bgee; ENSG00000162073; Expressed in C1 segment of cervical spinal cord and 170 other tissues.
DR ExpressionAtlas; Q8N4S7; baseline and differential.
DR Genevisible; Q8N4S7; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Receptor; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..273
FT /note="Progestin and adipoQ receptor family member 4"
FT /id="PRO_0000218848"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 56..130
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_011482"
FT VAR_SEQ 56..94
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_011481"
FT CONFLICT 54
FT /note="T -> A (in Ref. 2; BAC03821)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="A -> T (in Ref. 2; BAC03821)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="G -> E (in Ref. 2; BAB70758)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 273 AA; 29126 MW; 147C445B5EFAFFFD CRC64;
MAFLAGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHGLALL
GFLVLVPMTM PWGQLGKDGW LGGTHCVACL APPAGSVLYH LFMCHQGGSA VYARLLALDM
CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL VGYTVLSGVA GWRALTAPST SARLRAFGWQ
AAARLLVFGA RGVGLGSGAP GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH
QIMHLLSVGS ILQLHAGVVP DLLWAAHHAC PRD
