PAQR4_MOUSE
ID PAQR4_MOUSE Reviewed; 273 AA.
AC Q9JJE4; Q3U7G1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Progestin and adipoQ receptor family member 4 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member IV;
GN Name=Paqr4 {ECO:0000312|MGI:MGI:1923748}; ORFNames=MNCb-0914;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RA Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from mouse brain cDNA library made by
RT oligo-capping method.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Bone marrow, Brain cortex, Cecum, Cerebellum, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Eye, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424293; AAR08381.1; -; mRNA.
DR EMBL; AB041564; BAA95048.1; -; mRNA.
DR EMBL; AK005142; BAB23839.1; -; mRNA.
DR EMBL; AK033625; BAC28398.1; -; mRNA.
DR EMBL; AK044092; BAC31770.1; -; mRNA.
DR EMBL; AK044486; BAC31947.1; -; mRNA.
DR EMBL; AK152676; BAE31408.1; -; mRNA.
DR EMBL; BC011185; AAH11185.1; -; mRNA.
DR EMBL; BC026921; AAH26921.1; -; mRNA.
DR CCDS; CCDS28461.1; -.
DR RefSeq; NP_076313.1; NM_023824.3.
DR AlphaFoldDB; Q9JJE4; -.
DR SMR; Q9JJE4; -.
DR STRING; 10090.ENSMUSP00000024702; -.
DR iPTMnet; Q9JJE4; -.
DR PhosphoSitePlus; Q9JJE4; -.
DR SwissPalm; Q9JJE4; -.
DR MaxQB; Q9JJE4; -.
DR PaxDb; Q9JJE4; -.
DR PeptideAtlas; Q9JJE4; -.
DR PRIDE; Q9JJE4; -.
DR ProteomicsDB; 287948; -.
DR Antibodypedia; 42629; 30 antibodies from 13 providers.
DR DNASU; 76498; -.
DR Ensembl; ENSMUST00000024702; ENSMUSP00000024702; ENSMUSG00000023909.
DR GeneID; 76498; -.
DR KEGG; mmu:76498; -.
DR UCSC; uc008atb.1; mouse.
DR CTD; 124222; -.
DR MGI; MGI:1923748; Paqr4.
DR VEuPathDB; HostDB:ENSMUSG00000023909; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000157978; -.
DR HOGENOM; CLU_023075_0_1_1; -.
DR InParanoid; Q9JJE4; -.
DR OMA; HHACPPD; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q9JJE4; -.
DR TreeFam; TF323692; -.
DR BioGRID-ORCS; 76498; 5 hits in 76 CRISPR screens.
DR ChiTaRS; Paqr4; mouse.
DR PRO; PR:Q9JJE4; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9JJE4; protein.
DR Bgee; ENSMUSG00000023909; Expressed in pyloric antrum and 208 other tissues.
DR Genevisible; Q9JJE4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..273
FT /note="Progestin and adipoQ receptor family member 4"
FT /id="PRO_0000218849"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 273 AA; 29215 MW; 2D7568D439C351FD CRC64;
MAFLTGPRLL DWASSPPHLQ FNKFVLTGYR PASSGSGCLR SLFYLHNELG NIYTHGLALL
GFLVLVPMTM PWSQLGKDGW LGGTHCVACL VPPAASVLYH LFMCHQGGSP VYTRLLALDM
CGVCLVNTLG ALPIIHCTLA CRPWLRPAAL MGYTALSGVA GWRALTAPST SARLRAFGWQ
AGARLLVFGA RGVGLGSGAP GSLPCYLRMD ALALLGGLVN VARLPERWGP GRFDYWGNSH
QIMHLLSVGS ILQLHAGVVP DLLWAAHHAC PPD
