PAQR5_HUMAN
ID PAQR5_HUMAN Reviewed; 330 AA.
AC Q9NXK6; Q8IXU2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Membrane progestin receptor gamma {ECO:0000303|PubMed:23763432};
DE Short=mPR gamma {ECO:0000303|PubMed:23763432};
DE AltName: Full=Membrane progesterone P4 receptor gamma {ECO:0000303|PubMed:23763432};
DE AltName: Full=Membrane progesterone receptor gamma {ECO:0000303|PubMed:23763432};
DE AltName: Full=Progesterone and adipoQ receptor family member 5;
DE AltName: Full=Progestin and adipoQ receptor family member 5 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member V;
GN Name=PAQR5 {ECO:0000312|HGNC:HGNC:29645}; Synonyms=MPRG;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon mucosa;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-24.
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12601167; DOI=10.1073/pnas.0436133100;
RA Zhu Y., Bond J., Thomas P.;
RT "Identification, classification, and partial characterization of genes in
RT humans and other vertebrates homologous to a fish membrane progestin
RT receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
RN [5]
RP REVIEW.
RX PubMed=12606724; DOI=10.1073/pnas.0530224100;
RA Hammes S.R.;
RT "The further redefining of steroid-mediated signaling.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2168-2170(2003).
RN [6]
RP FUNCTION, REVIEW, AND SUBCELLULAR LOCATION.
RX PubMed=23763432; DOI=10.1111/jne.12060;
RA Petersen S.L., Intlekofer K.A., Moura-Conlon P.J., Brewer D.N.,
RA Del Pino Sans J., Lopez J.A.;
RT "Nonclassical progesterone signalling molecules in the nervous system.";
RL J. Neuroendocrinol. 25:991-1001(2013).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins (PubMed:23763432). Seems to act through a G(i) mediated
CC pathway (PubMed:23763432). May be involved in oocyte maturation
CC (PubMed:12601167). {ECO:0000269|PubMed:12601167,
CC ECO:0000303|PubMed:23763432}.
CC -!- INTERACTION:
CC Q9NXK6; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-10316423, EBI-781551;
CC Q9NXK6; Q8TED1: GPX8; NbExp=3; IntAct=EBI-10316423, EBI-11721746;
CC Q9NXK6; Q9P2J2-2: IGSF9; NbExp=3; IntAct=EBI-10316423, EBI-17451184;
CC Q9NXK6; P26951: IL3RA; NbExp=3; IntAct=EBI-10316423, EBI-1757512;
CC Q9NXK6; O95470: SGPL1; NbExp=3; IntAct=EBI-10316423, EBI-1046170;
CC Q9NXK6; Q8N205: SYNE4; NbExp=3; IntAct=EBI-10316423, EBI-7131783;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:23763432};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain, lung, kidney, colon,
CC adrenal and lung. {ECO:0000269|PubMed:12601167,
CC ECO:0000269|PubMed:16044242}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000303|PubMed:23763432}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424283; AAR08371.1; -; mRNA.
DR EMBL; AK000197; BAA91004.1; -; mRNA.
DR EMBL; BC039234; AAH39234.1; -; mRNA.
DR CCDS; CCDS10232.1; -.
DR RefSeq; NP_001098024.1; NM_001104554.1.
DR RefSeq; NP_060175.3; NM_017705.3.
DR RefSeq; XP_011520022.1; XM_011521720.2.
DR RefSeq; XP_011520024.1; XM_011521722.2.
DR RefSeq; XP_016877849.1; XM_017022360.1.
DR RefSeq; XP_016877850.1; XM_017022361.1.
DR RefSeq; XP_016877851.1; XM_017022362.1.
DR RefSeq; XP_016877852.1; XM_017022363.1.
DR RefSeq; XP_016877853.1; XM_017022364.1.
DR AlphaFoldDB; Q9NXK6; -.
DR SMR; Q9NXK6; -.
DR BioGRID; 120202; 13.
DR IntAct; Q9NXK6; 9.
DR STRING; 9606.ENSP00000378803; -.
DR iPTMnet; Q9NXK6; -.
DR PhosphoSitePlus; Q9NXK6; -.
DR BioMuta; PAQR5; -.
DR DMDM; 143811422; -.
DR MassIVE; Q9NXK6; -.
DR MaxQB; Q9NXK6; -.
DR PaxDb; Q9NXK6; -.
DR PeptideAtlas; Q9NXK6; -.
DR PRIDE; Q9NXK6; -.
DR ProteomicsDB; 83106; -.
DR Antibodypedia; 13981; 109 antibodies from 22 providers.
DR DNASU; 54852; -.
DR Ensembl; ENST00000340965.4; ENSP00000343877.3; ENSG00000137819.14.
DR Ensembl; ENST00000395407.7; ENSP00000378803.2; ENSG00000137819.14.
DR Ensembl; ENST00000561153.5; ENSP00000453526.1; ENSG00000137819.14.
DR GeneID; 54852; -.
DR KEGG; hsa:54852; -.
DR MANE-Select; ENST00000395407.7; ENSP00000378803.2; NM_017705.4; NP_060175.3.
DR UCSC; uc002arz.3; human.
DR CTD; 54852; -.
DR DisGeNET; 54852; -.
DR GeneCards; PAQR5; -.
DR HGNC; HGNC:29645; PAQR5.
DR HPA; ENSG00000137819; Tissue enhanced (kidney).
DR MIM; 607781; gene.
DR neXtProt; NX_Q9NXK6; -.
DR OpenTargets; ENSG00000137819; -.
DR PharmGKB; PA142671199; -.
DR VEuPathDB; HostDB:ENSG00000137819; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000158844; -.
DR HOGENOM; CLU_052356_1_0_1; -.
DR InParanoid; Q9NXK6; -.
DR OMA; GLCKMLR; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q9NXK6; -.
DR TreeFam; TF319738; -.
DR PathwayCommons; Q9NXK6; -.
DR SignaLink; Q9NXK6; -.
DR BioGRID-ORCS; 54852; 12 hits in 1070 CRISPR screens.
DR ChiTaRS; PAQR5; human.
DR GenomeRNAi; 54852; -.
DR Pharos; Q9NXK6; Tbio.
DR PRO; PR:Q9NXK6; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9NXK6; protein.
DR Bgee; ENSG00000137819; Expressed in metanephros cortex and 94 other tissues.
DR ExpressionAtlas; Q9NXK6; baseline and differential.
DR Genevisible; Q9NXK6; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Differentiation; Lipid-binding;
KW Membrane; Oogenesis; Receptor; Reference proteome; Steroid-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..330
FT /note="Membrane progestin receptor gamma"
FT /id="PRO_0000218843"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..141
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..253
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..294
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 316..330
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT VARIANT 24
FT /note="I -> T (in dbSNP:rs17853893)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031436"
FT CONFLICT 175
FT /note="I -> V (in Ref. 1; AAR08371 and 2; BAA91004)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 330 AA; 38014 MW; FA0AF2785EAAFFE8 CRC64;
MLSLKLPRLF SIDQIPQVFH EQGILFGYRH PQSSATACIL SLFQMTNETL NIWTHLLPFW
FFAWRFVTAL YMTDIKNDSY SWPMLVYMCT SCVYPLVSSC AHTFSSMSKN ARHICYFLDY
GAVNLFSLGS AIAYSAYTFP DALMCTTFHD YYVALAVLNT ILSTGLSCYS RFLEIQKPRL
CKVIRVLAFA YPYTWDSLPI FYRLFLFPGE SAQNEATSYH QKHMIMTLLA SFLYSAHLPE
RLAPGRFDYI GHSHQLFHVC VILATHMQME AILLDKTLRK EWLLATSKPF SFSQIAGAIL
LCIIFSLSNI IYFSAALYRI PKPELHKKET
