PAQR6_HUMAN
ID PAQR6_HUMAN Reviewed; 344 AA.
AC Q6TCH4; B7Z9R9; D3DVB4; D3DVB6; Q5TCK9; Q6PDU0; Q7Z4Q7; Q7Z4Q9; Q8N121;
AC Q8N3M2; Q9H621;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Membrane progestin receptor delta {ECO:0000303|PubMed:23763432};
DE Short=mPR delta {ECO:0000303|PubMed:23763432};
DE AltName: Full=Membrane progesterone P4 receptor delta {ECO:0000303|PubMed:23763432};
DE AltName: Full=Membrane progesterone receptor delta {ECO:0000303|PubMed:23763432};
DE AltName: Full=Progesterone and adipoQ receptor family member 6;
DE AltName: Full=Progestin and adipoQ receptor family member 6 {ECO:0000303|PubMed:16044242};
GN Name=PAQR6 {ECO:0000312|HGNC:HGNC:30132};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Brain;
RA Zan Q., Guo J.H., Yu L.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 126-344 (ISOFORMS 1/3/4).
RC TISSUE=Caudate nucleus, Small intestine, Subcommissural organ, and
RC Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 249-344 (ISOFORMS 1/3/4).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=23161870; DOI=10.1210/en.2012-1772;
RA Pang Y., Dong J., Thomas P.;
RT "Characterization, neurosteroid binding and brain distribution of human
RT membrane progesterone receptors delta and {epsilon} (mPRdelta and
RT mPR{epsilon}) and mPRdelta involvement in neurosteroid inhibition of
RT apoptosis.";
RL Endocrinology 154:283-295(2013).
RN [9]
RP FUNCTION, REVIEW, AND TISSUE SPECIFICITY.
RX PubMed=23763432; DOI=10.1111/jne.12060;
RA Petersen S.L., Intlekofer K.A., Moura-Conlon P.J., Brewer D.N.,
RA Del Pino Sans J., Lopez J.A.;
RT "Nonclassical progesterone signalling molecules in the nervous system.";
RL J. Neuroendocrinol. 25:991-1001(2013).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins (PubMed:23763432, PubMed:23161870). Seems to act through a
CC G(s) mediated pathway (PubMed:23161870). Involved in neurosteroid
CC inhibition of apoptosis (PubMed:23161870). May be involved in
CC regulating rapid P4 signaling in the nervous system (PubMed:23763432).
CC Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone
CC and allopregnanolone (PubMed:23763432, PubMed:23161870).
CC {ECO:0000269|PubMed:23161870, ECO:0000303|PubMed:23763432}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:23161870}.
CC -!- INTERACTION:
CC Q6TCH4; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-17265310, EBI-6942903;
CC Q6TCH4; Q8TED1: GPX8; NbExp=3; IntAct=EBI-17265310, EBI-11721746;
CC Q6TCH4; P15941-11: MUC1; NbExp=3; IntAct=EBI-17265310, EBI-17263240;
CC Q6TCH4; P50876: RNF144A; NbExp=3; IntAct=EBI-17265310, EBI-2340657;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23161870};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q6TCH4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6TCH4-2; Sequence=VSP_011484, VSP_011485;
CC Name=3;
CC IsoId=Q6TCH4-3; Sequence=VSP_011484;
CC Name=4;
CC IsoId=Q6TCH4-4; Sequence=VSP_011483;
CC Name=5;
CC IsoId=Q6TCH4-5; Sequence=VSP_054538;
CC -!- TISSUE SPECIFICITY: Brain specific (PubMed:16044242, PubMed:23763432).
CC Highly expressed in the hypothalamus, also expressed in forebrain,
CC amygdala, corpus callosum and spinal cord (PubMed:23161870).
CC {ECO:0000269|PubMed:16044242, ECO:0000269|PubMed:23161870,
CC ECO:0000303|PubMed:23763432}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000303|PubMed:23763432}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP97701.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAP97703.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAB15446.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF455045; AAP97701.1; ALT_FRAME; mRNA.
DR EMBL; AF455047; AAP97703.1; ALT_FRAME; mRNA.
DR EMBL; AY424284; AAR08372.1; -; mRNA.
DR EMBL; AK026325; BAB15446.1; ALT_INIT; mRNA.
DR EMBL; AK095143; BAC04493.1; -; mRNA.
DR EMBL; AK095197; BAC04497.1; -; mRNA.
DR EMBL; AK316034; BAH14405.1; -; mRNA.
DR EMBL; AL834227; CAD38905.2; -; Transcribed_RNA.
DR EMBL; AL135927; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471121; EAW52976.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52977.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52979.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52982.1; -; Genomic_DNA.
DR EMBL; CH471121; EAW52983.1; -; Genomic_DNA.
DR EMBL; BC058509; AAH58509.1; -; mRNA.
DR CCDS; CCDS1135.1; -. [Q6TCH4-2]
DR CCDS; CCDS1136.1; -. [Q6TCH4-1]
DR CCDS; CCDS60301.1; -. [Q6TCH4-5]
DR RefSeq; NP_001259033.1; NM_001272104.1. [Q6TCH4-1]
DR RefSeq; NP_001259034.1; NM_001272105.1. [Q6TCH4-5]
DR RefSeq; NP_001259036.1; NM_001272107.1. [Q6TCH4-3]
DR RefSeq; NP_001259037.1; NM_001272108.1.
DR RefSeq; NP_001259038.1; NM_001272109.1.
DR RefSeq; NP_001259039.1; NM_001272110.1.
DR RefSeq; NP_001259040.1; NM_001272111.1.
DR RefSeq; NP_001259041.1; NM_001272112.1.
DR RefSeq; NP_001259042.1; NM_001272113.1.
DR RefSeq; NP_079173.2; NM_024897.3. [Q6TCH4-2]
DR RefSeq; NP_940798.1; NM_198406.2. [Q6TCH4-1]
DR AlphaFoldDB; Q6TCH4; -.
DR SMR; Q6TCH4; -.
DR BioGRID; 123026; 8.
DR IntAct; Q6TCH4; 6.
DR MINT; Q6TCH4; -.
DR STRING; 9606.ENSP00000338330; -.
DR iPTMnet; Q6TCH4; -.
DR PhosphoSitePlus; Q6TCH4; -.
DR BioMuta; PAQR6; -.
DR DMDM; 51701773; -.
DR PaxDb; Q6TCH4; -.
DR PeptideAtlas; Q6TCH4; -.
DR PRIDE; Q6TCH4; -.
DR Antibodypedia; 2553; 98 antibodies from 16 providers.
DR DNASU; 79957; -.
DR Ensembl; ENST00000292291.10; ENSP00000292291.5; ENSG00000160781.17. [Q6TCH4-1]
DR Ensembl; ENST00000335852.6; ENSP00000338330.1; ENSG00000160781.17. [Q6TCH4-2]
DR Ensembl; ENST00000356983.7; ENSP00000349474.3; ENSG00000160781.17. [Q6TCH4-5]
DR Ensembl; ENST00000368270.2; ENSP00000357253.1; ENSG00000160781.17. [Q6TCH4-4]
DR GeneID; 79957; -.
DR KEGG; hsa:79957; -.
DR MANE-Select; ENST00000292291.10; ENSP00000292291.5; NM_198406.3; NP_940798.1.
DR UCSC; uc001fnu.3; human. [Q6TCH4-1]
DR CTD; 79957; -.
DR DisGeNET; 79957; -.
DR GeneCards; PAQR6; -.
DR HGNC; HGNC:30132; PAQR6.
DR HPA; ENSG00000160781; Group enriched (brain, choroid plexus).
DR MIM; 614579; gene.
DR neXtProt; NX_Q6TCH4; -.
DR OpenTargets; ENSG00000160781; -.
DR PharmGKB; PA134931897; -.
DR VEuPathDB; HostDB:ENSG00000160781; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000160567; -.
DR HOGENOM; CLU_052356_1_0_1; -.
DR InParanoid; Q6TCH4; -.
DR OMA; HQLFVPT; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q6TCH4; -.
DR TreeFam; TF319738; -.
DR PathwayCommons; Q6TCH4; -.
DR SignaLink; Q6TCH4; -.
DR BioGRID-ORCS; 79957; 29 hits in 1076 CRISPR screens.
DR ChiTaRS; PAQR6; human.
DR GenomeRNAi; 79957; -.
DR Pharos; Q6TCH4; Tbio.
DR PRO; PR:Q6TCH4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q6TCH4; protein.
DR Bgee; ENSG00000160781; Expressed in C1 segment of cervical spinal cord and 131 other tissues.
DR ExpressionAtlas; Q6TCH4; baseline and differential.
DR Genevisible; Q6TCH4; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Lipid-binding; Membrane; Receptor;
KW Reference proteome; Steroid-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..344
FT /note="Membrane progestin receptor delta"
FT /id="PRO_0000218850"
FT TOPO_DOM 1..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..83
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..217
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..292
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..344
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..106
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_011484"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_011483"
FT VAR_SEQ 15..17
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054538"
FT VAR_SEQ 255..344
FT /note="HSHQLFHICAVLGTHFQLEAVLADMGSRRAWLATQEPALGLAGTVATLVLAA
FT AGNLLIIAAFTATLLRAPSTCPLLQGGPLEGGTQAKQQ -> EGTPGPAREEAGADAFP
FT EHRMNWATATSYSTSVQCWAPTSSWRQCWLIWDHAEPGWPHRNLPWAWQAQWPHWSWLQ
FT LGTYSLLLLSQPPCFGPPVHALCCRVAHWRGVPRPNNSEAPSLTLSWRGQRPGPSADEE
FT PRFGPNQVGTHLSLEPTGAEERGHRREGREEEGCLGGLAECERDREGALDGSGRSAEGL
FT RGEMHACPG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_011485"
FT CONFLICT 166
FT /note="L -> P (in Ref. 2; AAR08372)"
FT /evidence="ECO:0000305"
FT CONFLICT 224
FT /note="G -> V (in Ref. 4; CAD38905)"
FT /evidence="ECO:0000305"
FT CONFLICT 240..242
FT /note="HLP -> QTD (in Ref. 1; AAP97703)"
FT /evidence="ECO:0000305"
FT CONFLICT 244
FT /note="R -> G (in Ref. 3; BAC04493)"
FT /evidence="ECO:0000305"
FT VARIANT Q6TCH4-2:263
FT /note="E -> K (in dbSNP:rs7513351)"
FT /evidence="ECO:0000305"
FT /id="VAR_082793"
SQ SEQUENCE 344 AA; 37989 MW; BCFDD8A2210A6989 CRC64;
MLSLKLPQLL QVHQVPRVFW EDGIMSGYRR PTSSALDCVL SSFQMTNETV NIWTHFLPTW
YFLWRLLALA GGPGFRAEPY HWPLLVFLLP ACLYPFASCC AHTFSSMSPR MRHICYFLDY
GALSLYSLGC AFPYAAYSMP ASWLHGHLHQ FFVPAAALNS FLCTGLSCYS RFLELESPGL
SKVLRTGAFA YPFLFDNLPL FYRLGLCWGR GHGCGQEALS TSHGYHLFCA LLTGFLFASH
LPERLAPGRF DYIGHSHQLF HICAVLGTHF QLEAVLADMG SRRAWLATQE PALGLAGTVA
TLVLAAAGNL LIIAAFTATL LRAPSTCPLL QGGPLEGGTQ AKQQ
