PAQR6_MOUSE
ID PAQR6_MOUSE Reviewed; 343 AA.
AC Q6TCG5; Q3UTT0; Q8CF56;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Membrane progestin receptor delta {ECO:0000250|UniProtKB:Q6TCH4};
DE Short=mPR delta {ECO:0000250|UniProtKB:Q6TCH4};
DE AltName: Full=Membrane progesterone P4 receptor delta {ECO:0000250|UniProtKB:Q6TCH4};
DE AltName: Full=Membrane progesterone receptor delta {ECO:0000250|UniProtKB:Q6TCH4};
DE AltName: Full=Progesterone and adipoQ receptor family member 6;
DE AltName: Full=Progestin and adipoQ receptor family member 6;
DE AltName: Full=Progestin and adipoQ receptor family member VI {ECO:0000250|UniProtKB:Q6TCH4};
GN Name=Paqr6 {ECO:0000312|MGI:MGI:1916207};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins. Seems to act through a G(s) mediated pathway. Involved in
CC neurosteroid inhibition of apoptosis. May be involved in regulating
CC rapid P4 signaling in the nervous system. Also binds
CC dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and
CC allopregnanolone. {ECO:0000250|UniProtKB:Q6TCH4}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q6TCH4}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6TCH4};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000250|UniProtKB:Q6TCH4}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424295; AAR08383.1; -; mRNA.
DR EMBL; AK139144; BAE23900.1; -; mRNA.
DR CCDS; CCDS17471.1; -.
DR RefSeq; NP_001297526.1; NM_001310597.1.
DR RefSeq; NP_940802.1; NM_198410.3.
DR AlphaFoldDB; Q6TCG5; -.
DR SMR; Q6TCG5; -.
DR STRING; 10090.ENSMUSP00000114166; -.
DR iPTMnet; Q6TCG5; -.
DR PhosphoSitePlus; Q6TCG5; -.
DR PaxDb; Q6TCG5; -.
DR PRIDE; Q6TCG5; -.
DR ProteomicsDB; 287950; -.
DR Antibodypedia; 2553; 98 antibodies from 16 providers.
DR DNASU; 68957; -.
DR Ensembl; ENSMUST00000147991; ENSMUSP00000114166; ENSMUSG00000041423.
DR GeneID; 68957; -.
DR KEGG; mmu:68957; -.
DR UCSC; uc012crs.1; mouse.
DR CTD; 79957; -.
DR MGI; MGI:1916207; Paqr6.
DR VEuPathDB; HostDB:ENSMUSG00000041423; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000160567; -.
DR HOGENOM; CLU_052356_1_0_1; -.
DR InParanoid; Q6TCG5; -.
DR OMA; HQLFVPT; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q6TCG5; -.
DR TreeFam; TF319738; -.
DR BioGRID-ORCS; 68957; 4 hits in 77 CRISPR screens.
DR ChiTaRS; Paqr6; mouse.
DR PRO; PR:Q6TCG5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q6TCG5; protein.
DR Bgee; ENSMUSG00000041423; Expressed in hypothalamus and 68 other tissues.
DR ExpressionAtlas; Q6TCG5; baseline and differential.
DR Genevisible; Q6TCG5; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Lipid-binding; Membrane; Receptor; Reference proteome;
KW Steroid-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..343
FT /note="Membrane progestin receptor delta"
FT /id="PRO_0000218851"
FT TOPO_DOM 1..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..79
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..112
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..216
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..343
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 343 AA; 38176 MW; 9B7BBCEAADA02FC2 CRC64;
MLSLKMPQLL RVHQVPRVFW EEGIMSGYRC PTSSALDCVL SSFQMTNETV NIWTHFLPTW
YFLWRLLALG SPGFRADPYH LPLLVFLLPA CLYPFASCCA HTFSSMSPRA RHICYFLDYG
ALSLYSLGCA FPYAAYSMPA SWLHSRLHQL FVPAAALNSF LCTGLSCYSR FPELEYPGFS
KALRTAAFAY PFLFDNLPLF YRLRLCWGGA HSCGRDALSS NHGYHLLCAL LSGFLFAARL
PERLAPGRFD YIGHSHQLFH ICAVLGTHFQ LEAVLADMGS RRAWLAVQEP TLGLGATVAT
LSLAVIGNLF IIAAFTASLL RMPGPCPLLQ GSPLEEGLQA KQQ
