PAQR7_MOUSE
ID PAQR7_MOUSE Reviewed; 345 AA.
AC Q80ZE4; Q3TDA0; Q8BNZ7; Q9D790;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Membrane progestin receptor alpha {ECO:0000250|UniProtKB:Q86WK9};
DE Short=mPR alpha {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Membrane progesterone P4 receptor alpha {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Membrane progesterone receptor alpha {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=PPAR-gamma-induced liver protein {ECO:0000303|PubMed:15589683};
DE AltName: Full=Progesterone and adipoQ receptor family member 7;
DE AltName: Full=Progestin and adipoQ receptor family member 7 {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Progestin and adipoQ receptor family member VII;
GN Name=Paqr7 {ECO:0000312|MGI:MGI:1919154}; Synonyms=Mpra, Pglp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=12601167; DOI=10.1073/pnas.0436133100;
RA Zhu Y., Bond J., Thomas P.;
RT "Identification, classification, and partial characterization of genes in
RT humans and other vertebrates homologous to a fish membrane progestin
RT receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=C57BL/6J;
RX PubMed=15589683; DOI=10.1016/j.biochi.2004.09.015;
RA Yu S., Viswakarma N., Batra S.K., Sambasiva Rao M., Reddy J.K.;
RT "Identification of promethin and PGLP as two novel up-regulated genes in
RT PPARgamma1-induced adipogenic mouse liver.";
RL Biochimie 86:743-761(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins. Seems to act through a G(i) mediated pathway. May be involved
CC in oocyte maturation. Involved in neurosteroid inhibition of apoptosis.
CC Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone
CC and allopregnanolone. {ECO:0000250|UniProtKB:Q86WK9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WK9};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Detected in most adult tissues. Higher expression
CC found in white fat and liver than brown fat and skeletal muscle.
CC {ECO:0000269|PubMed:15589683}.
CC -!- INDUCTION: Up-regulated in PPAR gamma 1-induced adipogenic liver.
CC {ECO:0000269|PubMed:15589683}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000250|UniProtKB:Q86WK9}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AF313618; AAO47231.1; -; mRNA.
DR EMBL; AY278956; AAP35062.1; -; mRNA.
DR EMBL; AY424296; AAR08384.1; -; mRNA.
DR EMBL; AK009450; BAB26296.1; -; mRNA.
DR EMBL; AK170307; BAE41704.1; -; mRNA.
DR EMBL; BC022922; AAH22922.1; -; mRNA.
DR CCDS; CCDS18773.1; -.
DR RefSeq; NP_001272774.1; NM_001285845.1.
DR RefSeq; NP_001272775.1; NM_001285846.1.
DR RefSeq; NP_001272776.1; NM_001285847.1.
DR RefSeq; NP_001272778.1; NM_001285849.1.
DR RefSeq; NP_082271.1; NM_027995.3.
DR RefSeq; XP_006539254.1; XM_006539191.3.
DR AlphaFoldDB; Q80ZE4; -.
DR SMR; Q80ZE4; -.
DR STRING; 10090.ENSMUSP00000080240; -.
DR iPTMnet; Q80ZE4; -.
DR PhosphoSitePlus; Q80ZE4; -.
DR MaxQB; Q80ZE4; -.
DR PaxDb; Q80ZE4; -.
DR PRIDE; Q80ZE4; -.
DR ProteomicsDB; 294009; -.
DR Antibodypedia; 30521; 171 antibodies from 26 providers.
DR DNASU; 71904; -.
DR Ensembl; ENSMUST00000081525; ENSMUSP00000080240; ENSMUSG00000037348.
DR Ensembl; ENSMUST00000095074; ENSMUSP00000125932; ENSMUSG00000037348.
DR GeneID; 71904; -.
DR KEGG; mmu:71904; -.
DR UCSC; uc008vfd.2; mouse.
DR CTD; 164091; -.
DR MGI; MGI:1919154; Paqr7.
DR VEuPathDB; HostDB:ENSMUSG00000037348; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000161438; -.
DR InParanoid; Q80ZE4; -.
DR OMA; VHRIYSC; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q80ZE4; -.
DR TreeFam; TF319738; -.
DR BioGRID-ORCS; 71904; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Paqr7; mouse.
DR PRO; PR:Q80ZE4; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q80ZE4; protein.
DR Bgee; ENSMUSG00000037348; Expressed in skin of external ear and 201 other tissues.
DR ExpressionAtlas; Q80ZE4; baseline and differential.
DR Genevisible; Q80ZE4; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003707; F:nuclear steroid receptor activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IBA:GO_Central.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048545; P:response to steroid hormone; IBA:GO_Central.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; Differentiation; Lipid-binding;
KW Membrane; Oogenesis; Receptor; Reference proteome; Steroid-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..345
FT /note="Membrane progestin receptor alpha"
FT /id="PRO_0000218836"
FT TOPO_DOM 1..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..345
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CONFLICT 280
FT /note="F -> L (in Ref. 1; AAO47231)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="H -> R (in Ref. 1; AAO47231)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 39306 MW; E7618A57C57B417B CRC64;
MAMAVAQKFN HLLSSLWHVG QKPPQPEPVF TVDRAQVPPL FWKPYIYAGY RPLHQNWCFY
FRTLFQRHNE AVNVWTHLLA ALALLLRLIG LAASVDFRED PHALPLFFIV LASFTYLSFS
AVAHLLQAKS EFWHYSFFFL DYVGVAVYQF GSALAHFYYA IEPSWHDKVQ AIFLPTAAFL
AWLSCAGSCY NKYSQKPGLL GRIFQEAPSA LAYVLDISPV LHRIIVSPLP AEEDPALLYH
KCQVVFFLLA AAFFSTVMPE SWFPGSCHIF GQGHQVFHVF LVLCTLAQLE AVTLDYQARR
GIYEPLHARW PHNFSGLFLL TVASSSLTAL LLSQLVRRKL HQKTK
