PAQR7_PIG
ID PAQR7_PIG Reviewed; 350 AA.
AC Q865K8;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Membrane progestin receptor alpha {ECO:0000250|UniProtKB:Q86WK9};
DE Short=mPR alpha {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Membrane progesterone P4 receptor alpha {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Membrane progesterone receptor alpha {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Progesterone and adipoQ receptor family member 7;
DE AltName: Full=Progestin and adipoQ receptor family member 7 {ECO:0000250|UniProtKB:Q86WK9};
DE AltName: Full=Progestin and adipoQ receptor family member VII;
GN Name=PAQR7; Synonyms=MRPA;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Small intestine;
RX PubMed=12601167; DOI=10.1073/pnas.0436133100;
RA Zhu Y., Bond J., Thomas P.;
RT "Identification, classification, and partial characterization of genes in
RT humans and other vertebrates homologous to a fish membrane progestin
RT receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins. Seems to act through a G(i) mediated pathway. May be involved
CC in oocyte maturation. Involved in neurosteroid inhibition of apoptosis.
CC Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone
CC and allopregnanolone. {ECO:0000250|UniProtKB:Q86WK9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WK9};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000250|UniProtKB:Q86WK9}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AF313616; AAO47229.1; -; mRNA.
DR RefSeq; NP_998904.1; NM_213739.1.
DR RefSeq; XP_003482048.1; XM_003482000.3.
DR RefSeq; XP_013854519.1; XM_013999065.1.
DR AlphaFoldDB; Q865K8; -.
DR SMR; Q865K8; -.
DR STRING; 9823.ENSSSCP00000003854; -.
DR PaxDb; Q865K8; -.
DR Ensembl; ENSSSCT00000003945; ENSSSCP00000003854; ENSSSCG00000003551.
DR Ensembl; ENSSSCT00000028664; ENSSSCP00000027353; ENSSSCG00000003551.
DR Ensembl; ENSSSCT00000076266; ENSSSCP00000062909; ENSSSCG00000003551.
DR Ensembl; ENSSSCT00000080288; ENSSSCP00000066848; ENSSSCG00000003551.
DR Ensembl; ENSSSCT00015080291; ENSSSCP00015032458; ENSSSCG00015060094.
DR Ensembl; ENSSSCT00015080438; ENSSSCP00015032509; ENSSSCG00015060094.
DR Ensembl; ENSSSCT00015080496; ENSSSCP00015032532; ENSSSCG00015060094.
DR Ensembl; ENSSSCT00015080585; ENSSSCP00015032574; ENSSSCG00015060094.
DR Ensembl; ENSSSCT00025023775; ENSSSCP00025009988; ENSSSCG00025017582.
DR Ensembl; ENSSSCT00025023786; ENSSSCP00025009997; ENSSSCG00025017582.
DR Ensembl; ENSSSCT00025023797; ENSSSCP00025010004; ENSSSCG00025017582.
DR Ensembl; ENSSSCT00025023808; ENSSSCP00025010013; ENSSSCG00025017582.
DR Ensembl; ENSSSCT00030067457; ENSSSCP00030030887; ENSSSCG00030048324.
DR Ensembl; ENSSSCT00030067462; ENSSSCP00030030889; ENSSSCG00030048324.
DR Ensembl; ENSSSCT00030067479; ENSSSCP00030030892; ENSSSCG00030048324.
DR Ensembl; ENSSSCT00030067489; ENSSSCP00030030895; ENSSSCG00030048324.
DR Ensembl; ENSSSCT00035105177; ENSSSCP00035045126; ENSSSCG00035077253.
DR Ensembl; ENSSSCT00035105252; ENSSSCP00035045165; ENSSSCG00035077253.
DR Ensembl; ENSSSCT00035105255; ENSSSCP00035045167; ENSSSCG00035077253.
DR Ensembl; ENSSSCT00035105270; ENSSSCP00035045177; ENSSSCG00035077253.
DR Ensembl; ENSSSCT00040103945; ENSSSCP00040047243; ENSSSCG00040075056.
DR Ensembl; ENSSSCT00040103955; ENSSSCP00040047249; ENSSSCG00040075056.
DR Ensembl; ENSSSCT00040103965; ENSSSCP00040047255; ENSSSCG00040075056.
DR Ensembl; ENSSSCT00040103974; ENSSSCP00040047261; ENSSSCG00040075056.
DR Ensembl; ENSSSCT00045066547; ENSSSCP00045047219; ENSSSCG00045038375.
DR Ensembl; ENSSSCT00045066560; ENSSSCP00045047230; ENSSSCG00045038375.
DR Ensembl; ENSSSCT00045066564; ENSSSCP00045047233; ENSSSCG00045038375.
DR Ensembl; ENSSSCT00045066574; ENSSSCP00045047239; ENSSSCG00045038375.
DR Ensembl; ENSSSCT00050069379; ENSSSCP00050029808; ENSSSCG00050050967.
DR Ensembl; ENSSSCT00050069380; ENSSSCP00050029809; ENSSSCG00050050967.
DR Ensembl; ENSSSCT00050069381; ENSSSCP00050029810; ENSSSCG00050050967.
DR Ensembl; ENSSSCT00050069385; ENSSSCP00050029812; ENSSSCG00050050967.
DR Ensembl; ENSSSCT00055036812; ENSSSCP00055029262; ENSSSCG00055018816.
DR Ensembl; ENSSSCT00055036882; ENSSSCP00055029318; ENSSSCG00055018816.
DR Ensembl; ENSSSCT00055036924; ENSSSCP00055029359; ENSSSCG00055018816.
DR Ensembl; ENSSSCT00055036968; ENSSSCP00055029391; ENSSSCG00055018816.
DR Ensembl; ENSSSCT00060100372; ENSSSCP00060043585; ENSSSCG00060073422.
DR Ensembl; ENSSSCT00060100411; ENSSSCP00060043602; ENSSSCG00060073422.
DR Ensembl; ENSSSCT00060100415; ENSSSCP00060043605; ENSSSCG00060073422.
DR Ensembl; ENSSSCT00060100419; ENSSSCP00060043609; ENSSSCG00060073422.
DR Ensembl; ENSSSCT00065005151; ENSSSCP00065002235; ENSSSCG00065003782.
DR Ensembl; ENSSSCT00065005153; ENSSSCP00065002237; ENSSSCG00065003782.
DR Ensembl; ENSSSCT00065005155; ENSSSCP00065002238; ENSSSCG00065003782.
DR Ensembl; ENSSSCT00065005158; ENSSSCP00065002240; ENSSSCG00065003782.
DR Ensembl; ENSSSCT00070052673; ENSSSCP00070044598; ENSSSCG00070026285.
DR Ensembl; ENSSSCT00070052676; ENSSSCP00070044601; ENSSSCG00070026285.
DR GeneID; 396558; -.
DR KEGG; ssc:396558; -.
DR CTD; 164091; -.
DR VGNC; VGNC:91177; PAQR7.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000161438; -.
DR HOGENOM; CLU_052356_0_0_1; -.
DR InParanoid; Q865K8; -.
DR OMA; VHRIYSC; -.
DR OrthoDB; 1524940at2759; -.
DR TreeFam; TF319738; -.
DR Proteomes; UP000008227; Chromosome 6.
DR Proteomes; UP000314985; Chromosome 6.
DR Bgee; ENSSSCG00000003551; Expressed in oocyte and 39 other tissues.
DR Genevisible; Q865K8; SS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003707; F:nuclear steroid receptor activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IBA:GO_Central.
DR GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR GO; GO:0048545; P:response to steroid hormone; IBA:GO_Central.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; Differentiation; Lipid-binding;
KW Membrane; Oogenesis; Receptor; Reference proteome; Steroid-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..350
FT /note="Membrane progestin receptor alpha"
FT /id="PRO_0000218837"
FT TOPO_DOM 1..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..278
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 300..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..350
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 350 AA; 39995 MW; E2E8320E6808AFF8 CRC64;
MATMVAQKLS HLLPSLRQVH PEPQPSVHPE PVFTVDRAEV PPLFWKPYIY VGYRPLHQTW
RFYFRTLFQQ HNEAVNVWTH LLAALVLLLR LAIFVGTVDF WGDPHALPLF IIVLASFTYL
SLSALAHLLQ AKSEFWHYSF FFLDYVGVAV YQFGSALAHF YYAIEPAWHA QVQTIFLPMA
AFLAWLSCTG SCYNKYIQKP GLLGRTCQEV PSALAYALDI SPVAHRILAS PEPATDDPAL
LYHKCQVVFF LLAAAFFSAF MPERWFPGSC HIFGQGHQLF HVFLVLCTLA QLEAVALDYE
ARRPIYEPLH TRWPHNFSGL FLLTVGSSIL TAFLLSQLVR RKLDLDRKTQ
