PAQR9_HUMAN
ID PAQR9_HUMAN Reviewed; 377 AA.
AC Q6ZVX9; Q147T6;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Membrane progestin receptor epsilon {ECO:0000303|PubMed:23763432};
DE Short=mPR epsilon {ECO:0000303|PubMed:23763432};
DE AltName: Full=Membrane progesterone P4 receptor epsilon {ECO:0000303|PubMed:23763432};
DE AltName: Full=Membrane progesterone receptor epsilon {ECO:0000303|PubMed:23763432};
DE AltName: Full=Progesterone and adipoQ receptor family member 9;
DE AltName: Full=Progestin and adipoQ receptor family member 9;
DE AltName: Full=Progestin and adipoQ receptor family member IX;
GN Name=PAQR9 {ECO:0000312|HGNC:HGNC:30131};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pericardium;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND SUBUNIT.
RX PubMed=23161870; DOI=10.1210/en.2012-1772;
RA Pang Y., Dong J., Thomas P.;
RT "Characterization, neurosteroid binding and brain distribution of human
RT membrane progesterone receptors delta and {epsilon} (mPRdelta and
RT mPR{epsilon}) and mPRdelta involvement in neurosteroid inhibition of
RT apoptosis.";
RL Endocrinology 154:283-295(2013).
RN [5]
RP FUNCTION, AND REVIEW.
RX PubMed=23763432; DOI=10.1111/jne.12060;
RA Petersen S.L., Intlekofer K.A., Moura-Conlon P.J., Brewer D.N.,
RA Del Pino Sans J., Lopez J.A.;
RT "Nonclassical progesterone signalling molecules in the nervous system.";
RL J. Neuroendocrinol. 25:991-1001(2013).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins (PubMed:23763432, PubMed:23161870). Seems to act through a
CC G(s) mediated pathway (PubMed:23161870). May be involved in regulating
CC rapid P4 signaling in the nervous system (PubMed:23763432). Also binds
CC dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and
CC allopregnanolone (PubMed:23161870). {ECO:0000269|PubMed:23161870,
CC ECO:0000303|PubMed:23763432}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:23161870}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23161870};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expression levels vary widely in a range of tissues
CC (PubMed:16044242). Expressed in the brain, at high level in the
CC pituitary gland and also in hypothalamus, limbic system, caudate
CC nucleus accumens, pons and olfactory bulb (PubMed:23161870).
CC {ECO:0000269|PubMed:16044242, ECO:0000269|PubMed:23161870}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000303|PubMed:23763432}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424287; AAR08375.1; -; mRNA.
DR EMBL; AK123932; BAC85729.1; -; mRNA.
DR EMBL; BC118666; AAI18667.1; -; mRNA.
DR EMBL; BC122527; AAI22528.1; -; mRNA.
DR CCDS; CCDS3128.1; -.
DR RefSeq; NP_940906.1; NM_198504.2.
DR AlphaFoldDB; Q6ZVX9; -.
DR BioGRID; 131327; 9.
DR STRING; 9606.ENSP00000341564; -.
DR iPTMnet; Q6ZVX9; -.
DR PhosphoSitePlus; Q6ZVX9; -.
DR BioMuta; PAQR9; -.
DR DMDM; 51701778; -.
DR jPOST; Q6ZVX9; -.
DR MassIVE; Q6ZVX9; -.
DR PaxDb; Q6ZVX9; -.
DR PeptideAtlas; Q6ZVX9; -.
DR PRIDE; Q6ZVX9; -.
DR ProteomicsDB; 68448; -.
DR Antibodypedia; 57880; 7 antibodies from 6 providers.
DR DNASU; 344838; -.
DR Ensembl; ENST00000340634.6; ENSP00000341564.4; ENSG00000188582.10.
DR GeneID; 344838; -.
DR KEGG; hsa:344838; -.
DR MANE-Select; ENST00000340634.6; ENSP00000341564.4; NM_198504.4; NP_940906.1.
DR UCSC; uc003evg.5; human.
DR CTD; 344838; -.
DR DisGeNET; 344838; -.
DR GeneCards; PAQR9; -.
DR HGNC; HGNC:30131; PAQR9.
DR HPA; ENSG00000188582; Tissue enhanced (liver, retina, testis).
DR MIM; 614580; gene.
DR neXtProt; NX_Q6ZVX9; -.
DR OpenTargets; ENSG00000188582; -.
DR PharmGKB; PA134880790; -.
DR VEuPathDB; HostDB:ENSG00000188582; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000162334; -.
DR HOGENOM; CLU_052356_1_0_1; -.
DR InParanoid; Q6ZVX9; -.
DR OMA; GYRRLHC; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q6ZVX9; -.
DR TreeFam; TF319738; -.
DR PathwayCommons; Q6ZVX9; -.
DR BioGRID-ORCS; 344838; 9 hits in 1064 CRISPR screens.
DR GenomeRNAi; 344838; -.
DR Pharos; Q6ZVX9; Tdark.
DR PRO; PR:Q6ZVX9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZVX9; protein.
DR Bgee; ENSG00000188582; Expressed in sperm and 63 other tissues.
DR ExpressionAtlas; Q6ZVX9; baseline and differential.
DR Genevisible; Q6ZVX9; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipid-binding; Membrane; Receptor; Reference proteome;
KW Steroid-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..377
FT /note="Membrane progestin receptor epsilon"
FT /id="PRO_0000218852"
FT TOPO_DOM 1..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..162
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 184..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..301
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 365..377
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 42692 MW; C1708C12C5C5A7C5 CRC64;
MPRRLQPRGA GTKGPPAPAP AASGAARNSH SAASRDPPAS AKPLLRWDEV PDDFVECFIL
SGYRRLPCTA QECLASVLKP TNETLNFWTH FIPLLLFLSK FCRLFFLSGG DVPFHHPWLL
PLWCYASGVL LTFAMSCTAH VFSCLSLRLR AAFFYLDYAS ISYYGFGSTV AYYYYLLPGL
SLLDARVMTP YLQQRLGWHV DCTRLIAAYR ALVLPVAFVL AVACTVACCK SRTDWCTYPF
ALRTFVFVMP LSMACPIMLE SWLFDLRGEN PTLFVHFYRR YFWLVVAAFF NVSKIPERIQ
PGLFDIIGHS HQLFHIFTFL SIYDQVYYVE EGLRQFLQAP PAAPTFSGTV GYMLLLVVCL
GLVIRKFLNS SEFCSKK
