PAQR9_MOUSE
ID PAQR9_MOUSE Reviewed; 375 AA.
AC Q6TCG2; Q3V0N1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Membrane progesterone receptor epsilon {ECO:0000250|UniProtKB:Q6ZVX9};
DE Short=mPR epsilon {ECO:0000250|UniProtKB:Q6ZVX9};
DE AltName: Full=Membrane progesterone P4 receptor epsilon {ECO:0000250|UniProtKB:Q6ZVX9};
DE AltName: Full=Membrane progestin receptor epsilon {ECO:0000250|UniProtKB:Q6ZVX9};
DE AltName: Full=Progesterone and adipoQ receptor family member 9;
DE AltName: Full=Progestin and adipoQ receptor family member 9 {ECO:0000250|UniProtKB:Q6ZVX9};
DE AltName: Full=Progestin and adipoQ receptor family member IX;
GN Name=Paqr9 {ECO:0000312|MGI:MGI:1922802};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
CC proteins. Seems to act through a G(s) mediated pathway. May be involved
CC in regulating rapid P4 signaling in the nervous system. Also binds
CC dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and
CC allopregnanolone. {ECO:0000250|UniProtKB:Q6ZVX9}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q6ZVX9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZVX9};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Non-classical progesterone receptors involved in
CC extranuclear signaling are classified in 2 groups: the class II
CC progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5,
CC PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding
CC protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).
CC {ECO:0000250|UniProtKB:Q6ZVX9}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424298; AAR08386.1; -; mRNA.
DR EMBL; AK133021; BAE21473.1; -; mRNA.
DR CCDS; CCDS23409.1; -.
DR RefSeq; NP_940806.2; NM_198414.2.
DR AlphaFoldDB; Q6TCG2; -.
DR SMR; Q6TCG2; -.
DR STRING; 10090.ENSMUSP00000078547; -.
DR iPTMnet; Q6TCG2; -.
DR PhosphoSitePlus; Q6TCG2; -.
DR SwissPalm; Q6TCG2; -.
DR jPOST; Q6TCG2; -.
DR MaxQB; Q6TCG2; -.
DR PaxDb; Q6TCG2; -.
DR PRIDE; Q6TCG2; -.
DR ProteomicsDB; 294381; -.
DR Antibodypedia; 57880; 7 antibodies from 6 providers.
DR DNASU; 75552; -.
DR Ensembl; ENSMUST00000079597; ENSMUSP00000078547; ENSMUSG00000064225.
DR GeneID; 75552; -.
DR KEGG; mmu:75552; -.
DR UCSC; uc009rbf.1; mouse.
DR CTD; 344838; -.
DR MGI; MGI:1922802; Paqr9.
DR VEuPathDB; HostDB:ENSMUSG00000064225; -.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000162334; -.
DR HOGENOM; CLU_052356_1_0_1; -.
DR InParanoid; Q6TCG2; -.
DR OMA; GYRRLHC; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q6TCG2; -.
DR TreeFam; TF319738; -.
DR BioGRID-ORCS; 75552; 1 hit in 75 CRISPR screens.
DR PRO; PR:Q6TCG2; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q6TCG2; protein.
DR Bgee; ENSMUSG00000064225; Expressed in left lobe of liver and 155 other tissues.
DR Genevisible; Q6TCG2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipid-binding; Membrane; Receptor; Reference proteome;
KW Steroid-binding; Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="Membrane progesterone receptor epsilon"
FT /id="PRO_0000218853"
FT TOPO_DOM 1..84
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 106..114
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 182..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..299
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 321..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 363..375
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 35
FT /note="P -> S (in Ref. 1; AAR08386)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 42741 MW; 673047F8770A3D02 CRC64;
MPRRLQQRGA GVKGPPASTS RRSHPASASA PRSPPAATTK PLLRWDEVPD DFVECFILSG
YRRLPCTAQE CLASVLKPTN ETLNFWTHFI PLLLFLSKFC RLFFLGGSDV PFHHPWLLPL
WCYASGVLLT FAMSCTAHVF SCLSLRLRAA FFYLDYASIS YYGFGSTVAY YYYLLPSLSL
LDARVMTPYV QQRLGWHVDC TRLIAVYRAL VLPVAFVLAV ACTVACCKSR TDWCSYPFAL
RTFVFVMPLS MACPIMLESW LFDLRGENPT LFVHFYRRYF WLVVAAFFNV SKIPERIQPG
LFDIIGHSHQ LFHIFTFLSI YDQVYYVEEG LRQFLQAPPA APTFSGTVGY MLLLVVCLGL
VIRKFLNSTE FCSKK
