PAQRA_HUMAN
ID PAQRA_HUMAN Reviewed; 270 AA.
AC Q8IY49; B5MBW4; Q6NVU5; Q6TCH0;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Monocyte to macrophage differentiation factor 2;
DE AltName: Full=Progestin and adipoQ receptor family member 10 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member X;
GN Name=MMD2 {ECO:0000312|HGNC:HGNC:30133};
GN Synonyms=PAQR10 {ECO:0000303|PubMed:16044242};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Brain, and Retinoblastoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP SUBCELLULAR LOCATION, AND MEMBRANE TOPOLOGY.
RX PubMed=22339580; DOI=10.1042/bj20112105;
RA Jin T., Xu D., Ding Q., Zhang Y., Mao C., Pan Y., Wang Z., Chen Y.;
RT "Identification of the topology and functional domains of PAQR10.";
RL Biochem. J. 443:643-653(2012).
CC -!- INTERACTION:
CC Q8IY49-2; P07307-3: ASGR2; NbExp=3; IntAct=EBI-13349813, EBI-12808270;
CC Q8IY49-2; P11912: CD79A; NbExp=3; IntAct=EBI-13349813, EBI-7797864;
CC Q8IY49-2; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-13349813, EBI-6942903;
CC Q8IY49-2; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-13349813, EBI-18304435;
CC Q8IY49-2; O95470: SGPL1; NbExp=3; IntAct=EBI-13349813, EBI-1046170;
CC Q8IY49-2; Q8WWF3: SSMEM1; NbExp=3; IntAct=EBI-13349813, EBI-17280858;
CC Q8IY49-2; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-13349813, EBI-8638294;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:22339580}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:22339580}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8IY49-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IY49-2; Sequence=VSP_011486;
CC Name=3;
CC IsoId=Q8IY49-3; Sequence=VSP_011486, VSP_045589;
CC -!- TISSUE SPECIFICITY: Shows restricted expression with highest levels in
CC brain and testis. {ECO:0000269|PubMed:16044242}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY424288; AAR08376.1; -; mRNA.
DR EMBL; AC053546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC092032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471144; EAW87307.1; -; Genomic_DNA.
DR EMBL; BC037881; AAH37881.2; -; mRNA.
DR EMBL; BC048346; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC067905; AAH67905.1; -; mRNA.
DR CCDS; CCDS47529.1; -. [Q8IY49-1]
DR CCDS; CCDS47530.1; -. [Q8IY49-2]
DR CCDS; CCDS59047.1; -. [Q8IY49-3]
DR RefSeq; NP_001094070.1; NM_001100600.1. [Q8IY49-1]
DR RefSeq; NP_001257304.1; NM_001270375.1. [Q8IY49-3]
DR RefSeq; NP_940685.3; NM_198403.3. [Q8IY49-2]
DR AlphaFoldDB; Q8IY49; -.
DR SMR; Q8IY49; -.
DR BioGRID; 128770; 8.
DR IntAct; Q8IY49; 7.
DR STRING; 9606.ENSP00000384690; -.
DR TCDB; 1.C.113.2.3; the hemolysin iii (hly iii) family.
DR PhosphoSitePlus; Q8IY49; -.
DR BioMuta; MMD2; -.
DR DMDM; 51701810; -.
DR PaxDb; Q8IY49; -.
DR PeptideAtlas; Q8IY49; -.
DR PRIDE; Q8IY49; -.
DR ProteomicsDB; 5944; -.
DR ProteomicsDB; 71107; -. [Q8IY49-1]
DR ProteomicsDB; 71108; -. [Q8IY49-2]
DR Antibodypedia; 24544; 122 antibodies from 19 providers.
DR DNASU; 221938; -.
DR Ensembl; ENST00000401401.8; ENSP00000384141.3; ENSG00000136297.15. [Q8IY49-2]
DR Ensembl; ENST00000404774.7; ENSP00000384690.3; ENSG00000136297.15. [Q8IY49-1]
DR Ensembl; ENST00000406755.5; ENSP00000385963.1; ENSG00000136297.15. [Q8IY49-3]
DR Ensembl; ENST00000612910.1; ENSP00000484193.1; ENSG00000136297.15. [Q8IY49-3]
DR GeneID; 221938; -.
DR KEGG; hsa:221938; -.
DR MANE-Select; ENST00000401401.8; ENSP00000384141.3; NM_198403.4; NP_940685.3. [Q8IY49-2]
DR UCSC; uc003snn.5; human. [Q8IY49-1]
DR CTD; 221938; -.
DR GeneCards; MMD2; -.
DR HGNC; HGNC:30133; MMD2.
DR HPA; ENSG00000136297; Tissue enhanced (brain, retina, testis).
DR MalaCards; MMD2; -.
DR MIM; 614581; gene.
DR neXtProt; NX_Q8IY49; -.
DR OpenTargets; ENSG00000136297; -.
DR PharmGKB; PA134910250; -.
DR VEuPathDB; HostDB:ENSG00000136297; -.
DR eggNOG; KOG4243; Eukaryota.
DR GeneTree; ENSGT00940000157972; -.
DR HOGENOM; CLU_051078_0_0_1; -.
DR InParanoid; Q8IY49; -.
DR OMA; YHRRVWS; -.
DR OrthoDB; 1487730at2759; -.
DR PhylomeDB; Q8IY49; -.
DR TreeFam; TF313370; -.
DR PathwayCommons; Q8IY49; -.
DR SignaLink; Q8IY49; -.
DR BioGRID-ORCS; 221938; 12 hits in 1046 CRISPR screens.
DR ChiTaRS; MMD2; human.
DR GenomeRNAi; 221938; -.
DR Pharos; Q8IY49; Tbio.
DR PRO; PR:Q8IY49; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IY49; protein.
DR Bgee; ENSG00000136297; Expressed in C1 segment of cervical spinal cord and 70 other tissues.
DR Genevisible; Q8IY49; HS.
DR GO; GO:0030173; C:integral component of Golgi membrane; IDA:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
DR GO; GO:0004672; F:protein kinase activity; IDA:CACAO.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:CACAO.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:CACAO.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:CACAO.
DR GO; GO:0032880; P:regulation of protein localization; IDA:CACAO.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Golgi apparatus; Membrane; Receptor;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..270
FT /note="Monocyte to macrophage differentiation factor 2"
FT /id="PRO_0000218857"
FT TOPO_DOM 1..38
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..59
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 60..65
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..132
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..182
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..205
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..270
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT VAR_SEQ 156..179
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16044242"
FT /id="VSP_011486"
FT VAR_SEQ 204..270
FT /note="PNTEGIWELVTGGVFYCLGMVFFKSDGRIPFAHAIWHLFVAFGAGTHYYAIW
FT RYLYLPSTLQTKVSK -> AGKLRPGMTCLKRQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045589"
FT CONFLICT 9
FT /note="F -> L (in Ref. 1; AAR08376)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="V -> L (in Ref. 4; AAH37881)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="L -> I (in Ref. 4; AAH67905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 270 AA; 31264 MW; A726231D6283A2DA CRC64;
MFAPRLLDFQ KTKYARFMNH RVPAHKRYQP TEYEHAANCA THAFWIIPSI LGSSNLYFLS
DDDWETISAW IYGLGLCGLF VVSTVFHTIS WKKSHLRMVE HCLHMFDRMV IYFFIAASYA
PWLNLRELGP WASHMRWLVW IMASVGTIYV FFFHERTGSC VQFLRGEACP KAGTACLPAR
YKLVELLCYV VMGFFPALVI LSMPNTEGIW ELVTGGVFYC LGMVFFKSDG RIPFAHAIWH
LFVAFGAGTH YYAIWRYLYL PSTLQTKVSK
