PAQRA_MOUSE
ID PAQRA_MOUSE Reviewed; 247 AA.
AC Q8R189;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Monocyte to macrophage differentiation factor 2;
DE AltName: Full=Progestin and adipoQ receptor family member 10 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member X;
GN Name=Mmd2 {ECO:0000312|MGI:MGI:1922354};
GN Synonyms=Paqr10 {ECO:0000303|PubMed:16044242};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=12617826; DOI=10.1016/s1567-133x(02)00022-4;
RA Menke D.B., Page D.C.;
RT "Sexually dimorphic gene expression in the developing mouse gonad.";
RL Gene Expr. Patterns 2:359-367(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the testicular cords at 13.5 dpc.
CC {ECO:0000269|PubMed:12617826}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY134664; AAN08615.1; -; mRNA.
DR EMBL; AY424299; AAR08387.1; -; mRNA.
DR EMBL; BC025064; AAH25064.1; -; mRNA.
DR CCDS; CCDS39363.1; -.
DR RefSeq; NP_780426.1; NM_175217.6.
DR AlphaFoldDB; Q8R189; -.
DR SMR; Q8R189; -.
DR STRING; 10090.ENSMUSP00000039357; -.
DR iPTMnet; Q8R189; -.
DR PhosphoSitePlus; Q8R189; -.
DR PaxDb; Q8R189; -.
DR PRIDE; Q8R189; -.
DR ProteomicsDB; 294382; -.
DR Antibodypedia; 24544; 122 antibodies from 19 providers.
DR DNASU; 75104; -.
DR Ensembl; ENSMUST00000037048; ENSMUSP00000039357; ENSMUSG00000039533.
DR GeneID; 75104; -.
DR KEGG; mmu:75104; -.
DR UCSC; uc009aix.1; mouse.
DR CTD; 221938; -.
DR MGI; MGI:1922354; Mmd2.
DR VEuPathDB; HostDB:ENSMUSG00000039533; -.
DR eggNOG; KOG4243; Eukaryota.
DR GeneTree; ENSGT00940000157972; -.
DR HOGENOM; CLU_051078_0_0_1; -.
DR InParanoid; Q8R189; -.
DR OMA; YHRRVWS; -.
DR OrthoDB; 1487730at2759; -.
DR PhylomeDB; Q8R189; -.
DR TreeFam; TF313370; -.
DR BioGRID-ORCS; 75104; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8R189; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8R189; protein.
DR Bgee; ENSMUSG00000039533; Expressed in substantia nigra and 179 other tissues.
DR ExpressionAtlas; Q8R189; baseline and differential.
DR Genevisible; Q8R189; MM.
DR GO; GO:0030173; C:integral component of Golgi membrane; ISS:UniProtKB.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0004672; F:protein kinase activity; ISO:MGI.
DR GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:MGI.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:MGI.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:MGI.
DR GO; GO:0032880; P:regulation of protein localization; ISO:MGI.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR005744; Hy-lIII.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
DR TIGRFAMs; TIGR01065; hlyIII; 1.
PE 2: Evidence at transcript level;
KW Golgi apparatus; Membrane; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..247
FT /note="Monocyte to macrophage differentiation factor 2"
FT /id="PRO_0000218858"
FT TOPO_DOM 1..39
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..66
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..133
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..182
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 232..247
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 247 AA; 28910 MW; 29F0D683E7022060 CRC64;
MFTLARLLDF QKTKYARFMN DRVPAHKRYQ PTEYEHAANC ATHAFWIIPS ILGSSNLYFL
SDDDWETISA WIYGLGLCGL FVVSTIFHTV SWKKSHLRMV EHCLHMIDRM VIYFFIAASY
APWLNLRELG PWASHMRWLV WIMASIGTIY VFFFHERYKL VELLCYVVMG FFPALVILSM
PNTDGIWELM TGGAFYCLGM VFFKSDGRIP FAHAIWHLFV AFGAGTHYYA IWRYLYLPST
LQTKVSK
