PAQRB_HUMAN
ID PAQRB_HUMAN Reviewed; 238 AA.
AC Q15546; B2R6X9; D3DTY6; Q8TAN7;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Monocyte to macrophage differentiation factor {ECO:0000303|PubMed:7503749};
DE AltName: Full=Progestin and adipoQ receptor family member 11 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member XI;
GN Name=MMD {ECO:0000312|HGNC:HGNC:7153};
GN Synonyms=PAQR11 {ECO:0000303|PubMed:16044242};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Blood;
RX PubMed=7503749; DOI=10.1006/bbrc.1995.2825;
RA Rehli M., Krause S.W., Schwarzfischer L., Kreutz M., Andreesen R.;
RT "Molecular cloning of a novel macrophage maturation-associated transcript
RT encoding a protein with several potential transmembrane domains.";
RL Biochem. Biophys. Res. Commun. 217:661-667(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the dynamics of lysosomal membranes associated
CC with microglial activation following brain lesion. {ECO:0000250}.
CC -!- INTERACTION:
CC Q15546; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-17873222, EBI-11522760;
CC Q15546; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-17873222, EBI-11343438;
CC Q15546; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-17873222, EBI-12069500;
CC Q15546; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-17873222, EBI-12003442;
CC Q15546; P78329: CYP4F2; NbExp=3; IntAct=EBI-17873222, EBI-1752413;
CC Q15546; Q9BV81: EMC6; NbExp=3; IntAct=EBI-17873222, EBI-2820492;
CC Q15546; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-17873222, EBI-18304435;
CC Q15546; P01350: GAST; NbExp=3; IntAct=EBI-17873222, EBI-3436637;
CC Q15546; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-17873222, EBI-13345167;
CC Q15546; Q8TED1: GPX8; NbExp=3; IntAct=EBI-17873222, EBI-11721746;
CC Q15546; P11836: MS4A1; NbExp=3; IntAct=EBI-17873222, EBI-2808234;
CC Q15546; Q9NX40: OCIAD1; NbExp=3; IntAct=EBI-17873222, EBI-2683029;
CC Q15546; Q53GL0: PLEKHO1; NbExp=3; IntAct=EBI-17873222, EBI-949945;
CC Q15546; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-17873222, EBI-9679163;
CC Q15546; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-17873222, EBI-355861;
CC Q15546; Q969S6: TMEM203; NbExp=3; IntAct=EBI-17873222, EBI-12274070;
CC Q15546; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-17873222, EBI-12038591;
CC Q15546; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-17873222, EBI-2852148;
CC Q15546; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-17873222, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Exhibits relatively ubiquitous expression with
CC preferential expression in mature (in vitro differentiated)
CC macrophages. {ECO:0000269|PubMed:16044242}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; X85750; CAA59752.1; -; mRNA.
DR EMBL; AY424289; AAR08377.1; -; mRNA.
DR EMBL; CR541893; CAG46691.1; -; mRNA.
DR EMBL; AK312760; BAG35626.1; -; mRNA.
DR EMBL; CH471109; EAW94541.1; -; Genomic_DNA.
DR EMBL; CH471109; EAW94542.1; -; Genomic_DNA.
DR EMBL; BC026324; AAH26324.1; -; mRNA.
DR CCDS; CCDS11586.1; -.
DR PIR; JC4503; JC4503.
DR RefSeq; NP_036461.2; NM_012329.2.
DR AlphaFoldDB; Q15546; -.
DR SMR; Q15546; -.
DR BioGRID; 117077; 24.
DR IntAct; Q15546; 19.
DR STRING; 9606.ENSP00000262065; -.
DR TCDB; 1.C.113.2.1; the hemolysin iii (hly iii) family.
DR iPTMnet; Q15546; -.
DR PhosphoSitePlus; Q15546; -.
DR BioMuta; MMD; -.
DR DMDM; 62512174; -.
DR PaxDb; Q15546; -.
DR PeptideAtlas; Q15546; -.
DR PRIDE; Q15546; -.
DR ProteomicsDB; 60628; -.
DR Antibodypedia; 52797; 8 antibodies from 6 providers.
DR DNASU; 23531; -.
DR Ensembl; ENST00000262065.8; ENSP00000262065.3; ENSG00000108960.9.
DR GeneID; 23531; -.
DR KEGG; hsa:23531; -.
DR MANE-Select; ENST00000262065.8; ENSP00000262065.3; NM_012329.3; NP_036461.2.
DR UCSC; uc002iui.4; human.
DR CTD; 23531; -.
DR DisGeNET; 23531; -.
DR GeneCards; MMD; -.
DR HGNC; HGNC:7153; MMD.
DR HPA; ENSG00000108960; Group enriched (adipose tissue, brain).
DR MIM; 604467; gene.
DR neXtProt; NX_Q15546; -.
DR OpenTargets; ENSG00000108960; -.
DR PharmGKB; PA30863; -.
DR VEuPathDB; HostDB:ENSG00000108960; -.
DR eggNOG; KOG4243; Eukaryota.
DR GeneTree; ENSGT00940000157428; -.
DR HOGENOM; CLU_051078_0_0_1; -.
DR InParanoid; Q15546; -.
DR OMA; HEVFHSL; -.
DR OrthoDB; 1487730at2759; -.
DR PhylomeDB; Q15546; -.
DR TreeFam; TF313370; -.
DR PathwayCommons; Q15546; -.
DR SignaLink; Q15546; -.
DR BioGRID-ORCS; 23531; 42 hits in 1089 CRISPR screens.
DR GenomeRNAi; 23531; -.
DR Pharos; Q15546; Tbio.
DR PRO; PR:Q15546; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q15546; protein.
DR Bgee; ENSG00000108960; Expressed in nucleus accumbens and 205 other tissues.
DR ExpressionAtlas; Q15546; baseline and differential.
DR Genevisible; Q15546; HS.
DR GO; GO:0005794; C:Golgi apparatus; IDA:CACAO.
DR GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0004672; F:protein kinase activity; IDA:CACAO.
DR GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:CACAO.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; IDA:CACAO.
DR GO; GO:0032880; P:regulation of protein localization; IDA:CACAO.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR005744; Hy-lIII.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
DR TIGRFAMs; TIGR01065; hlyIII; 1.
PE 1: Evidence at protein level;
KW Endosome; Lysosome; Membrane; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..238
FT /note="Monocyte to macrophage differentiation factor"
FT /id="PRO_0000218854"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123..124
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..174
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CONFLICT 75
FT /note="V -> A (in Ref. 1; CAA59752)"
FT /evidence="ECO:0000305"
FT CONFLICT 92
FT /note="V -> A (in Ref. 1; CAA59752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 27667 MW; 0B7328C85911F184 CRC64;
MRFKNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH RLSDDCWEKI
TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD RMVIYFFIAA SYAPWLNLRE
LGPLASHMRW FIWLMAAGGT IYVFLYHEKY KVVELFFYLT MGFSPALVVT SMNNTDGLQE
LACGGLIYCL GVVFFKSDGI IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFMRHL
