PAQRB_MOUSE
ID PAQRB_MOUSE Reviewed; 238 AA.
AC Q9CQY7; Q3TAU1; Q5SVU7;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Monocyte to macrophage differentiation factor {ECO:0000250|UniProtKB:Q15546};
DE AltName: Full=Progestin and adipoQ receptor family member 11 {ECO:0000303|PubMed:16044242};
DE AltName: Full=Progestin and adipoQ receptor family member XI;
GN Name=Mmd {ECO:0000312|MGI:MGI:1914718};
GN Synonyms=Paqr11 {ECO:0000303|PubMed:16044242};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
RA Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
RA Funk W.D.;
RT "PAQR proteins: a novel membrane receptor family defined by an ancient 7-
RT transmembrane pass motif.";
RL J. Mol. Evol. 61:372-380(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Lung, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in the dynamics of lysosomal membranes associated
CC with microglial activation following brain lesion. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAI24626.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY424300; AAR08388.1; -; mRNA.
DR EMBL; AK004819; BAB23590.1; -; mRNA.
DR EMBL; AK011418; BAB27606.1; -; mRNA.
DR EMBL; AK158577; BAE34564.1; -; mRNA.
DR EMBL; AK171637; BAE42577.1; -; mRNA.
DR EMBL; AL626785; CAI24626.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL626785; CAI24627.1; -; Genomic_DNA.
DR EMBL; BC021914; AAH21914.1; -; mRNA.
DR CCDS; CCDS25240.1; -.
DR RefSeq; NP_080454.1; NM_026178.2.
DR AlphaFoldDB; Q9CQY7; -.
DR SMR; Q9CQY7; -.
DR STRING; 10090.ENSMUSP00000004050; -.
DR iPTMnet; Q9CQY7; -.
DR PhosphoSitePlus; Q9CQY7; -.
DR MaxQB; Q9CQY7; -.
DR PaxDb; Q9CQY7; -.
DR PRIDE; Q9CQY7; -.
DR ProteomicsDB; 294010; -.
DR Antibodypedia; 52797; 8 antibodies from 6 providers.
DR DNASU; 67468; -.
DR Ensembl; ENSMUST00000004050; ENSMUSP00000004050; ENSMUSG00000003948.
DR GeneID; 67468; -.
DR KEGG; mmu:67468; -.
DR UCSC; uc007kwo.1; mouse.
DR CTD; 23531; -.
DR MGI; MGI:1914718; Mmd.
DR VEuPathDB; HostDB:ENSMUSG00000003948; -.
DR eggNOG; KOG4243; Eukaryota.
DR GeneTree; ENSGT00940000157428; -.
DR HOGENOM; CLU_051078_0_0_1; -.
DR InParanoid; Q9CQY7; -.
DR OMA; HEVFHSL; -.
DR OrthoDB; 1487730at2759; -.
DR PhylomeDB; Q9CQY7; -.
DR TreeFam; TF313370; -.
DR BioGRID-ORCS; 67468; 5 hits in 74 CRISPR screens.
DR ChiTaRS; Mmd; mouse.
DR PRO; PR:Q9CQY7; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CQY7; protein.
DR Bgee; ENSMUSG00000003948; Expressed in epididymal fat pad and 269 other tissues.
DR ExpressionAtlas; Q9CQY7; baseline and differential.
DR Genevisible; Q9CQY7; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004672; F:protein kinase activity; ISO:MGI.
DR GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:MGI.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:MGI.
DR GO; GO:0032880; P:regulation of protein localization; ISO:MGI.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR005744; Hy-lIII.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
DR TIGRFAMs; TIGR01065; hlyIII; 1.
PE 2: Evidence at transcript level;
KW Endosome; Lysosome; Membrane; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..238
FT /note="Monocyte to macrophage differentiation factor"
FT /id="PRO_0000218855"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..174
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 238 AA; 27677 MW; 401E99C419B9F65B CRC64;
MRFRNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH RLSDDCWEKI
TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD RMVIYFFIAA SYAPWLNLRE
LGPLASHMRW FIWLMAAGGT IYVFLYHEKY KVVELFFYLT MGFSPALVVT SMNNTDGLQE
LACGGLIYCL GVVFFKSDGI IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFIRHL
