PAQRB_RAT
ID PAQRB_RAT Reviewed; 238 AA.
AC Q719N3;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Monocyte to macrophage differentiation factor {ECO:0000250|UniProtKB:Q15546};
DE AltName: Full=Macrophage/microglia activation-associated factor {ECO:0000303|PubMed:15063720};
DE Short=MAF;
DE AltName: Full=Progestin and adipoQ receptor family member 11 {ECO:0000250|UniProtKB:Q15546};
DE AltName: Full=Progestin and adipoQ receptor family member XI;
GN Name=Mmd {ECO:0000312|RGD:1592079};
GN Synonyms=Maf, Paqr11 {ECO:0000250|UniProtKB:Q15546};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Brain;
RX PubMed=15063720; DOI=10.1016/s0014-5793(04)00244-3;
RA Braeuer A.U., Nitsch R., Savaskan N.E.;
RT "Identification of macrophage/microglia activation factor (MAF) associated
RT with late endosomes/lysosomes in microglial cells.";
RL FEBS Lett. 563:41-48(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Is involved in the dynamics of lysosomal membranes associated
CC with microglial activation following brain lesion.
CC {ECO:0000269|PubMed:15063720}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000269|PubMed:15063720}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15063720}. Lysosome membrane
CC {ECO:0000269|PubMed:15063720}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15063720}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in the brain.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AF540876; AAQ11225.1; -; mRNA.
DR EMBL; BC081965; AAH81965.1; -; mRNA.
DR RefSeq; NP_001007674.1; NM_001007673.1.
DR RefSeq; XP_006247188.1; XM_006247126.2.
DR AlphaFoldDB; Q719N3; -.
DR SMR; Q719N3; -.
DR STRING; 10116.ENSRNOP00000003308; -.
DR PhosphoSitePlus; Q719N3; -.
DR PaxDb; Q719N3; -.
DR Ensembl; ENSRNOT00000087765; ENSRNOP00000075635; ENSRNOG00000002436.
DR GeneID; 303439; -.
DR KEGG; rno:303439; -.
DR CTD; 23531; -.
DR RGD; 1592079; Mmd.
DR eggNOG; KOG4243; Eukaryota.
DR GeneTree; ENSGT00940000157428; -.
DR HOGENOM; CLU_051078_0_0_1; -.
DR InParanoid; Q719N3; -.
DR OMA; HEVFHSL; -.
DR OrthoDB; 1487730at2759; -.
DR PhylomeDB; Q719N3; -.
DR TreeFam; TF313370; -.
DR PRO; PR:Q719N3; -.
DR Proteomes; UP000002494; Chromosome 10.
DR Bgee; ENSRNOG00000002436; Expressed in Ammon's horn and 20 other tissues.
DR ExpressionAtlas; Q719N3; baseline and differential.
DR Genevisible; Q719N3; RN.
DR GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004672; F:protein kinase activity; ISO:RGD.
DR GO; GO:0019835; P:cytolysis; IEA:InterPro.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISO:RGD.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:RGD.
DR GO; GO:0032880; P:regulation of protein localization; ISO:RGD.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR InterPro; IPR005744; Hy-lIII.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
DR TIGRFAMs; TIGR01065; hlyIII; 1.
PE 2: Evidence at transcript level;
KW Endosome; Lysosome; Membrane; Receptor; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..238
FT /note="Monocyte to macrophage differentiation factor"
FT /id="PRO_0000218856"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..61
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..101
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 123
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..174
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 238 AA; 27648 MW; 28732F1F74FF1235 CRC64;
MQFRNRFQRF MNHRAPANGR YKPTCYEHAA NCYTHAFLIV PAIVGSALLH RLSDDCWEKI
TAWIYGMGLC ALFIVSTVFH IVSWKKSHLR TVEHCFHMCD RMVIYFFIAA SYAPWLNLRE
LGPLASHMRW FIWLMAAGGT IYVFLYHEKY KVVELFFYLT MGFSPALVVT SMNNTDGLQE
LACGGLIYCL GVVFFKSDGI IPFAHAIWHL FVATAAAVHY YAIWKYLYRS PTDFIRHL
