PAR2_ARATH
ID PAR2_ARATH Reviewed; 118 AA.
AC Q9LXR7;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Transcription factor PAR2;
DE AltName: Full=Basic helix-loop-helix protein 166;
DE Short=AtbHLH166;
DE Short=bHLH 166;
DE AltName: Full=Protein HELIX-LOOP-HELIX 2;
DE AltName: Full=Protein PHYTOCHROME RAPIDLY REGULATED 2;
DE AltName: Full=bHLH transcription factor bHLH166;
GN Name=PAR2; Synonyms=BHLH166, HLH2; OrderedLocusNames=At3g58850;
GN ORFNames=T20N10.200;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Cafardi V.;
RT "Role of HLH1 and HLH2 in the shade avoidance response of Arabidopsis
RT thaliana.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RX PubMed=17948056; DOI=10.1038/sj.emboj.7601890;
RA Roig-Villanova I., Bou-Torrent J., Galstyan A., Carretero-Paulet L.,
RA Portoles S., Rodriguez-Concepcion M., Martinez-Garcia J.F.;
RT "Interaction of shade avoidance and auxin responses: a role for two novel
RT atypical bHLH proteins.";
RL EMBO J. 26:4756-4767(2007).
CC -!- FUNCTION: Atypical bHLH transcription factor that acts as negative
CC regulator of a variety of shade avoidance syndrome (SAS) responses,
CC including seedling elongation and photosynthetic pigment accumulation.
CC Acts as direct transcriptional repressor of two auxin-responsive genes,
CC SAUR15 and SAUR68. May function in integrating shade and hormone
CC transcriptional networks in response to light and auxin changes.
CC {ECO:0000269|PubMed:17948056}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981,
CC ECO:0000269|PubMed:17948056}.
CC -!- DISRUPTION PHENOTYPE: Slight increase in the length of hypocotyls,
CC cotyledons and primary leaves. {ECO:0000269|PubMed:17948056}.
CC -!- MISCELLANEOUS: Plants overexpressing PAR1 are dwarf with compact
CC rosettes and inflorescences, epinastic leaves, shorter flowering stems
CC and siliques and a general dark-green phenotype.
CC {ECO:0000305|PubMed:17948056}.
CC -!- SIMILARITY: Belongs to the bHLH protein family. {ECO:0000305}.
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DR EMBL; AM905847; CAP19901.1; -; mRNA.
DR EMBL; AL353032; CAB88302.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79840.1; -; Genomic_DNA.
DR EMBL; BT011205; AAR92241.1; -; mRNA.
DR EMBL; BT012139; AAS76234.1; -; mRNA.
DR EMBL; AK229232; BAF01099.1; -; mRNA.
DR PIR; T49168; T49168.
DR RefSeq; NP_191444.1; NM_115747.4.
DR AlphaFoldDB; Q9LXR7; -.
DR SMR; Q9LXR7; -.
DR BioGRID; 10369; 2.
DR STRING; 3702.AT3G58850.1; -.
DR PaxDb; Q9LXR7; -.
DR PRIDE; Q9LXR7; -.
DR EnsemblPlants; AT3G58850.1; AT3G58850.1; AT3G58850.
DR GeneID; 825054; -.
DR Gramene; AT3G58850.1; AT3G58850.1; AT3G58850.
DR KEGG; ath:AT3G58850; -.
DR Araport; AT3G58850; -.
DR TAIR; locus:2099004; AT3G58850.
DR eggNOG; ENOG502S830; Eukaryota.
DR HOGENOM; CLU_111355_1_0_1; -.
DR InParanoid; Q9LXR7; -.
DR OMA; KKDMKFG; -.
DR OrthoDB; 1459159at2759; -.
DR PhylomeDB; Q9LXR7; -.
DR PRO; PR:Q9LXR7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LXR7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0009742; P:brassinosteroid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007623; P:circadian rhythm; IEP:TAIR.
DR GO; GO:0032502; P:developmental process; IMP:TAIR.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0009641; P:shade avoidance; IMP:TAIR.
DR CDD; cd11444; bHLH_AtIBH1_like; 1.
DR InterPro; IPR044549; bHLH_AtIBH1-like.
DR InterPro; IPR044660; IBH1-like.
DR PANTHER; PTHR33124; PTHR33124; 1.
PE 3: Inferred from homology;
KW Brassinosteroid signaling pathway; Growth regulation; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..118
FT /note="Transcription factor PAR2"
FT /id="PRO_0000429107"
FT DOMAIN 43..92
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 118 AA; 12872 MW; 10B8CFFB7B328548 CRC64;
MEKTLATSHT KRSSPPSPSS AVNTSSTGFN RRTRQRLSDA TASVSETDVE DEDEDEEGVE
EKIEALQTIV PGGTELGVDA LFEETASYIL ALQCQINAIK VLTTFLERCE KKDMKFGG
