PARA_ECOLX
ID PARA_ECOLX Reviewed; 398 AA.
AC P07620;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Plasmid partition protein A;
GN Name=parA;
OS Escherichia coli.
OG Plasmid P1.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=562;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3903163; DOI=10.1016/0022-2836(85)90402-4;
RA Abeles A.L., Friedman S.A., Austin S.J.;
RT "Partition of unit-copy miniplasmids to daughter cells. III. The DNA
RT sequence and functional organization of the P1 partition region.";
RL J. Mol. Biol. 185:261-272(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1836760;
RA de Boer P.A.J., Crossley R.E., Hand A.R., Rothfield L.I.;
RT "The MinD protein is a membrane ATPase required for the correct placement
RT of the Escherichia coli division site.";
RL EMBO J. 10:4371-4380(1991).
CC -!- FUNCTION: This protein is essential for plasmid partition. It ensures
CC the proper distribution of newly replicated plasmids to daughter cells
CC during cell division. ParA is trans-acting.
CC -!- INTERACTION:
CC P07620; P07620: parA; NbExp=3; IntAct=EBI-7011519, EBI-7011519;
CC -!- SIMILARITY: Belongs to the ParA family. {ECO:0000305}.
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DR EMBL; K02380; AAA99230.1; -; Genomic_DNA.
DR EMBL; X02954; CAA26698.1; -; Genomic_DNA.
DR PDB; 3EZ2; X-ray; 2.05 A; A/B=1-398.
DR PDB; 3EZ6; X-ray; 2.58 A; A/B=1-398.
DR PDB; 3EZ7; X-ray; 2.92 A; A=1-398.
DR PDBsum; 3EZ2; -.
DR PDBsum; 3EZ6; -.
DR PDBsum; 3EZ7; -.
DR AlphaFoldDB; P07620; -.
DR SMR; P07620; -.
DR IntAct; P07620; 1.
DR MINT; P07620; -.
DR EvolutionaryTrace; P07620; -.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0030541; P:plasmid partitioning; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR041250; HTH_54.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF18607; HTH_54; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Plasmid; Plasmid partition.
FT CHAIN 1..398
FT /note="Plasmid partition protein A"
FT /id="PRO_0000068404"
FT HELIX 6..25
FT /evidence="ECO:0007829|PDB:3EZ2"
FT TURN 26..28
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 43..48
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 54..67
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 73..75
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 86..95
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 101..103
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 109..113
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 116..121
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 122..135
FT /evidence="ECO:0007829|PDB:3EZ2"
FT TURN 137..139
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 140..142
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 146..151
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 156..161
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 164..167
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 174..180
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 184..190
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 200..203
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 209..214
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 216..223
FT /evidence="ECO:0007829|PDB:3EZ2"
FT TURN 229..231
FT /evidence="ECO:0007829|PDB:3EZ7"
FT HELIX 232..236
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 238..241
FT /evidence="ECO:0007829|PDB:3EZ2"
FT TURN 242..244
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 246..252
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 254..256
FT /evidence="ECO:0007829|PDB:3EZ7"
FT HELIX 258..266
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 268..274
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 278..300
FT /evidence="ECO:0007829|PDB:3EZ2"
FT STRAND 310..317
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 321..334
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 335..337
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 347..354
FT /evidence="ECO:0007829|PDB:3EZ2"
FT TURN 359..361
FT /evidence="ECO:0007829|PDB:3EZ2"
FT TURN 364..366
FT /evidence="ECO:0007829|PDB:3EZ2"
FT HELIX 371..397
FT /evidence="ECO:0007829|PDB:3EZ2"
SQ SEQUENCE 398 AA; 44270 MW; 9CB45EB82B8ADBCE CRC64;
MSDSSQLHKV AQRANRMLNV LTEQVQLQKD ELHANEFYQV YAKAALAKLP LLTRANVDYA
VSEMEEKGYV FDKRPAGSSM KYAMSIQNII DIYEHRGVPK YRDRYSEAYV IFISNLKGGV
SKTVSTVSLA HAMRAHPHLL MEDLRILVID LDPQSSATMF LSHKHSIGIV NATSAQAMLQ
NVSREELLEE FIVPSVVPGV DVMPASIDDA FIASDWRELC NEHLPGQNIH AVLKENVIDK
LKSDYDFILV DSGPHLDAFL KNALASANIL FTPLPPATVD FHSSLKYVAR LPELVKLISD
EGCECQLATN IGFMSKLSNK ADHKYCHSLA KEVFGGDMLD VFLPRLDGFE RCGESFDTVI
SANPATYVGS ADALKNARIA AEDFAKAVFD RIEFIRSN
