ID   PARA_TRYBB              Reviewed;         114 AA.
AC   P18764;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Procyclic form-specific polypeptide A-alpha;
DE   AltName: Full=PARP A-alpha;
DE   AltName: Full=Procyclin A-alpha;
DE   Flags: Precursor;
GN   Name=PARPA-ALPHA;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2725502; DOI=10.1128/mcb.9.3.1332-1335.1989;
RA   Mowatt M.R., Wisdom G.S., Clayton C.E.;
RT   "Variation of tandem repeats in the developmentally regulated procyclic
RT   acidic repetitive proteins of Trypanosoma brucei.";
RL   Mol. Cell. Biol. 9:1332-1335(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2342468; DOI=10.1128/mcb.10.6.3036-3047.1990;
RA   Clayton C.E., Fueri J.P., Itzhaki J.E., Bellofatto V., Sherman D.R.,
RA   Wisdom G.S., Vijayasarathy S., Mowatt M.R.;
RT   "Transcription of the procyclic acidic repetitive protein genes of
RT   Trypanosoma brucei.";
RL   Mol. Cell. Biol. 10:3036-3047(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=427;
RA   Vijayasarathy S., Ernest I., Itzhaki J., Sherman D., Mowatt M.R.,
RA   Michels P.A.M., Clayton C.E.;
RL   Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Major surface antigen of procyclic forms.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed only at a certain stage during
CC       differentiation in the insect vector.
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DR   EMBL; M25787; AAA53283.1; -; Genomic_DNA.
DR   EMBL; M33129; AAA30224.1; -; Genomic_DNA.
DR   EMBL; X52584; CAA36814.1; -; Genomic_DNA.
DR   PIR; A30229; A30229.
DR   AlphaFoldDB; P18764; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008882; Trypano_PARP.
DR   Pfam; PF05887; Trypan_PARP; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Repeat;
KW   Signal.
FT   SIGNAL          1..27
FT   CHAIN           28..92
FT                   /note="Procyclic form-specific polypeptide A-alpha"
FT                   /id="PRO_0000022011"
FT   PROPEP          93..114
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000022012"
FT   REPEAT          48..52
FT                   /note="1"
FT   REPEAT          56..60
FT                   /note="2"
FT   REPEAT          61..65
FT                   /note="3"
FT   REPEAT          66..70
FT                   /note="4"
FT   REPEAT          71..75
FT                   /note="5"
FT   REPEAT          76..80
FT                   /note="6"
FT   REPEAT          81..85
FT                   /note="7"
FT   REGION          33..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..85
FT                   /note="7 X 5 AA tandem repeats of G-P-E-E-[PT]"
FT   COMPBIAS        51..86
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           92
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   114 AA;  11611 MW;  FFF2690DAAAE445E CRC64;
     MAPRSLYLLA ILLFSANLFA GVGFAAAADE SASNVIVKGG KGKEREDGPE EPEETGPEET
     GPEETGPEET GPEETGPEET GPEETEPEPE PGAATLKSVA LPFAVAAAAL VAAF