ID   PARB4_ECOLX             Reviewed;         281 AA.
AC   P22997; Q52337; Q56389;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Protein ParB;
GN   Name=parB;
OS   Escherichia coli.
OG   Plasmid IncP-alpha RP4.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2172207; DOI=10.1128/jb.172.11.6194-6203.1990;
RA   Gerlitz M., Hrabak O., Schwab H.;
RT   "Partitioning of broad-host-range plasmid RP4 is a complex system involving
RT   site-specific recombination.";
RL   J. Bacteriol. 172:6194-6203(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 105-190.
RX   PubMed=8387603; DOI=10.1006/jmbi.1993.1228;
RA   Kholodii G.Y., Yurieva O.V., Lomovskaya O.L., Gorlenko Z.M., Mindlin S.Z.,
RA   Nikiforov V.G.;
RT   "Tn5053, a mercury resistance transposon with integron's ends.";
RL   J. Mol. Biol. 230:1103-1107(1993).
CC   -!- FUNCTION: Involved in plasmid partition.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA26416.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L40585; AAA98320.1; -; Genomic_DNA.
DR   EMBL; M59825; AAA26415.1; -; Genomic_DNA.
DR   EMBL; M59825; AAA26416.1; ALT_INIT; Genomic_DNA.
DR   EMBL; L03728; AAA91496.1; -; Genomic_DNA.
DR   PIR; C37141; C37141.
DR   PIR; S32828; S32828.
DR   AlphaFoldDB; P22997; -.
DR   SMR; P22997; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0030541; P:plasmid partitioning; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.50.90; -; 1.
DR   InterPro; IPR035437; SNase_OB-fold_sf.
DR   InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR   InterPro; IPR002071; Thermonucl_AS.
DR   Pfam; PF00565; SNase; 1.
DR   SMART; SM00318; SNc; 1.
DR   SUPFAM; SSF50199; SSF50199; 1.
DR   PROSITE; PS01123; TNASE_1; 1.
DR   PROSITE; PS01284; TNASE_2; 1.
DR   PROSITE; PS50830; TNASE_3; 1.
PE   4: Predicted;
KW   Endonuclease; Hydrolase; Nuclease; Plasmid; Plasmid partition.
FT   CHAIN           1..281
FT                   /note="Protein ParB"
FT                   /id="PRO_0000215282"
FT   DOMAIN          130..261
FT                   /note="TNase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00272"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..54
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        157
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        165
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        199
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   281 AA;  31289 MW;  01907DD37F531370 CRC64;
     MPARLGPNGY TQFDQGGRDE GGQALPTTSI HRLQHRGAGL RAWTRRHTRP AHPRPGARGP
     RPARPGRVPF AGVRLAGGAG RLLQGQFRCS AAPGVPRSSA MGPRMKRRSY AMLRAAAALA
     VLVVASPAWA ELRGEVVRII DGDTIDVLVD KQPVRVRLVD IDAPEKRQAF GERARQALAG
     MVFRRHVLVD EKDTDRYGRT LGTVWVNMEL ASRPPQPRNV NAAMVHQGMA WAYRFHGRAA
     DPEMLRLEQE ARGKRVGLWS DPHAVEPWKW RRESNNRRDE G