PARB_CAUVN
ID PARB_CAUVN Reviewed; 304 AA.
AC B8GW30; O05190;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2015, sequence version 2.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Chromosome-partitioning protein ParB {ECO:0000303|PubMed:9054507};
GN Name=parB {ECO:0000303|PubMed:9054507}; OrderedLocusNames=CCNA_03868;
OS Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Caulobacter.
OX NCBI_TaxID=565050;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, DNA-BINDING, AND SUBCELLULAR
RP LOCATION.
RX PubMed=9054507; DOI=10.1016/s0092-8674(00)81910-8;
RA Mohl D.A., Gober J.W.;
RT "Cell cycle-dependent polar localization of chromosome partitioning
RT proteins in Caulobacter crescentus.";
RL Cell 88:675-684(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NA1000 / CB15N;
RX PubMed=20472802; DOI=10.1128/jb.00255-10;
RA Marks M.E., Castro-Rojas C.M., Teiling C., Du L., Kapatral V.,
RA Walunas T.L., Crosson S.;
RT "The genetic basis of laboratory adaptation in Caulobacter crescentus.";
RL J. Bacteriol. 192:3678-3688(2010).
CC -!- FUNCTION: Involved in chromosome partition. Localize to both poles of
CC the predivisional cell following completion of DNA replication. Binds
CC to the DNA origin of replication. {ECO:0000269|PubMed:9054507}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9054507}.
CC Note=Subcellular distribution changes during the cell cycle. In swarmer
CC cells, where DNA replication does not occur, ParB is for the most part
CC distributed throughout the cell. As DNA replication proceeds, ParB
CC begins to concentrate at one pole of the predivisional cell. Finally,
CC in late predivisional cells, following the completion of DNA
CC replication, ParB is distributed to both poles of the cell.
CC {ECO:0000269|PubMed:9054507}.
CC -!- SIMILARITY: Belongs to the ParB family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB51268.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U87804; AAB51268.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP001340; ACL97333.2; -; Genomic_DNA.
DR RefSeq; WP_024266006.1; NC_011916.1.
DR RefSeq; YP_002519241.4; NC_011916.1.
DR PDB; 6S6H; X-ray; 2.40 A; A/B=126-254.
DR PDB; 6T1F; X-ray; 2.90 A; A/B/C/D=11-254.
DR PDB; 7BM8; X-ray; 2.73 A; A/B=11-254.
DR PDBsum; 6S6H; -.
DR PDBsum; 6T1F; -.
DR PDBsum; 7BM8; -.
DR AlphaFoldDB; B8GW30; -.
DR SMR; B8GW30; -.
DR IntAct; B8GW30; 1.
DR MINT; B8GW30; -.
DR PRIDE; B8GW30; -.
DR EnsemblBacteria; ACL97333; ACL97333; CCNA_03868.
DR GeneID; 7332716; -.
DR KEGG; ccs:CCNA_03868; -.
DR PATRIC; fig|565050.3.peg.3773; -.
DR HOGENOM; CLU_023853_0_0_5; -.
DR OrthoDB; 653368at2; -.
DR Proteomes; UP000001364; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR InterPro; IPR041468; HTH_ParB/Spo0J.
DR InterPro; IPR004437; ParB/RepB/Spo0J.
DR InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR Pfam; PF17762; HTH_ParB; 1.
DR Pfam; PF02195; ParBc; 1.
DR SMART; SM00470; ParB; 1.
DR SUPFAM; SSF110849; SSF110849; 1.
DR TIGRFAMs; TIGR00180; parB_part; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome partition; Cytoplasm; DNA-binding;
KW Reference proteome.
FT CHAIN 1..304
FT /note="Chromosome-partitioning protein ParB"
FT /id="PRO_0000378301"
FT REGION 236..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 25..36
FT /note="LLGEVDAAPAQA -> CWASRRRAGSG (in Ref. 1; AAB51268)"
FT /evidence="ECO:0000305"
FT CONFLICT 41
FT /note="L -> F (in Ref. 1; AAB51268)"
FT /evidence="ECO:0000305"
FT STRAND 45..48
FT /evidence="ECO:0007829|PDB:7BM8"
FT HELIX 49..51
FT /evidence="ECO:0007829|PDB:7BM8"
FT STRAND 52..54
FT /evidence="ECO:0007829|PDB:7BM8"
FT HELIX 65..78
FT /evidence="ECO:0007829|PDB:7BM8"
FT STRAND 84..88
FT /evidence="ECO:0007829|PDB:7BM8"
FT STRAND 90..92
FT /evidence="ECO:0007829|PDB:7BM8"
FT STRAND 96..100
FT /evidence="ECO:0007829|PDB:7BM8"
FT HELIX 102..110
FT /evidence="ECO:0007829|PDB:7BM8"
FT STRAND 114..120
FT /evidence="ECO:0007829|PDB:7BM8"
FT HELIX 128..135
FT /evidence="ECO:0007829|PDB:6S6H"
FT TURN 136..139
FT /evidence="ECO:0007829|PDB:6S6H"
FT HELIX 144..158
FT /evidence="ECO:0007829|PDB:6S6H"
FT HELIX 162..169
FT /evidence="ECO:0007829|PDB:6S6H"
FT HELIX 173..181
FT /evidence="ECO:0007829|PDB:6S6H"
FT HELIX 182..184
FT /evidence="ECO:0007829|PDB:6S6H"
FT HELIX 187..195
FT /evidence="ECO:0007829|PDB:6S6H"
FT STRAND 196..198
FT /evidence="ECO:0007829|PDB:6T1F"
FT HELIX 200..205
FT /evidence="ECO:0007829|PDB:6S6H"
FT TURN 206..208
FT /evidence="ECO:0007829|PDB:6S6H"
FT STRAND 209..211
FT /evidence="ECO:0007829|PDB:7BM8"
FT HELIX 212..222
FT /evidence="ECO:0007829|PDB:6S6H"
FT HELIX 226..234
FT /evidence="ECO:0007829|PDB:6S6H"
FT TURN 238..241
FT /evidence="ECO:0007829|PDB:6S6H"
SQ SEQUENCE 304 AA; 32809 MW; 930BD2D2D4B83ECF CRC64;
MESVVVGEPG MSEGRRGLGR GLSALLGEVD AAPAQAPGEQ LGGSREAPIE ILQRNPDQPR
RTFREEDLED LSNSIREKGV LQPILVRPSP DTAGEYQIVA GERRWRAAQR AGLKTVPIMV
RELDDLAVLE IGIIENVQRA DLNVLEEALS YKVLMEKFER TQENIAQTIG KSRSHVANTM
RLLALPDEVQ SYLVSGELTA GHARAIAAAA DPVALAKQII EGGLSVRETE ALARKAPNLS
AGKSKGGRPP RVKDTDTQAL ESDLSSVLGL DVSIDHRGST GTLTITYATL EQLDDLCNRL
TRGI
