ID   PARB_MYCTU              Reviewed;         344 AA.
AC   P9WIJ9; L0TH09; O53595; O53596; P0A5R2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Probable chromosome-partitioning protein ParB;
GN   Name=parB; OrderedLocusNames=Rv3917c; ORFNames=MTV028.08c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Involved in chromosome partition. Localize to both poles of
CC       the predivisional cell following completion of DNA replication. Binds
CC       to the DNA origin of replication (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Belongs to the ParB family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46746.1; -; Genomic_DNA.
DR   PIR; E70851; E70851.
DR   PIR; F70851; F70851.
DR   RefSeq; NP_218435.2; NC_000962.3.
DR   RefSeq; WP_003400175.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WIJ9; -.
DR   SMR; P9WIJ9; -.
DR   STRING; 83332.Rv3917c; -.
DR   PaxDb; P9WIJ9; -.
DR   DNASU; 886244; -.
DR   GeneID; 886244; -.
DR   KEGG; mtu:Rv3917c; -.
DR   PATRIC; fig|83332.111.peg.4362; -.
DR   TubercuList; Rv3917c; -.
DR   eggNOG; COG1475; Bacteria.
DR   OMA; IALSYQR; -.
DR   PhylomeDB; P9WIJ9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0060187; C:cell pole; IDA:MTBBASE.
DR   GO; GO:0005694; C:chromosome; IDA:MTBBASE.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR   GO; GO:0045881; P:positive regulation of sporulation resulting in formation of a cellular spore; IBA:GO_Central.
DR   InterPro; IPR041468; HTH_ParB/Spo0J.
DR   InterPro; IPR004437; ParB/RepB/Spo0J.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   Pfam; PF17762; HTH_ParB; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   SMART; SM00470; ParB; 1.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   TIGRFAMs; TIGR00180; parB_part; 1.
PE   1: Evidence at protein level;
KW   Chromosome partition; DNA-binding; Reference proteome.
FT   CHAIN           1..344
FT                   /note="Probable chromosome-partitioning protein ParB"
FT                   /id="PRO_0000178685"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          259..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   344 AA;  37018 MW;  80EA58A7ED27DEBD CRC64;
     MTQPSRRKGG LGRGLAALIP TGPADGESGP PTLGPRMGSA TADVVIGGPV PDTSVMGAIY
     REIPPSAIEA NPRQPRQVFD EEALAELVHS IREFGLLQPI VVRSLAGSQT GVRYQIVMGE
     RRWRAAQEAG LATIPAIVRE TGDDNLLRDA LLENIHRVQL NPLEEAAAYQ QLLDEFGVTH
     DELAARIGRS RPLITNMIRL LKLPIPVQRR VAAGVLSAGH ARALLSLEAG PEAQEELASR
     IVAEGLSVRA TEETVTLANH EANRQAHHSD ATTPAPPRRK PIQMPGLQDV AERLSTTFDT
     RVTVSLGKRK GKIVVEFGSV DDLARIVGLM TTDGRDKGLH RDAL