PARC_HAEIN
ID PARC_HAEIN Reviewed; 747 AA.
AC P43702;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=DNA topoisomerase 4 subunit A {ECO:0000255|HAMAP-Rule:MF_00936};
DE EC=5.6.2.2 {ECO:0000255|HAMAP-Rule:MF_00936};
DE AltName: Full=Topoisomerase IV subunit A {ECO:0000255|HAMAP-Rule:MF_00936};
GN Name=parC {ECO:0000255|HAMAP-Rule:MF_00936}; OrderedLocusNames=HI_1529;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Topoisomerase IV is essential for chromosome segregation. It
CC relaxes supercoiled DNA. Performs the decatenation events required
CC during the replication of a circular DNA molecule. {ECO:0000255|HAMAP-
CC Rule:MF_00936}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00936};
CC -!- SUBUNIT: Heterotetramer composed of ParC and ParE. {ECO:0000255|HAMAP-
CC Rule:MF_00936}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00936};
CC Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_00936}.
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. ParC type 1 subfamily. {ECO:0000255|HAMAP-Rule:MF_00936}.
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DR EMBL; L42023; AAC23175.1; -; Genomic_DNA.
DR PIR; F64127; F64127.
DR RefSeq; NP_439678.1; NC_000907.1.
DR RefSeq; WP_005693555.1; NC_000907.1.
DR AlphaFoldDB; P43702; -.
DR SMR; P43702; -.
DR STRING; 71421.HI_1529; -.
DR DrugBank; DB06771; Besifloxacin.
DR DrugBank; DB00537; Ciprofloxacin.
DR DrugBank; DB00467; Enoxacin.
DR DrugBank; DB09047; Finafloxacin.
DR DrugBank; DB04576; Fleroxacin.
DR DrugBank; DB01155; Gemifloxacin.
DR DrugBank; DB00365; Grepafloxacin.
DR DrugBank; DB01137; Levofloxacin.
DR DrugBank; DB00978; Lomefloxacin.
DR DrugBank; DB00218; Moxifloxacin.
DR DrugBank; DB01059; Norfloxacin.
DR DrugBank; DB01165; Ofloxacin.
DR DrugBank; DB00487; Pefloxacin.
DR DrugBank; DB01208; Sparfloxacin.
DR DrugBank; DB01405; Temafloxacin.
DR DrugBank; DB00685; Trovafloxacin.
DR EnsemblBacteria; AAC23175; AAC23175; HI_1529.
DR KEGG; hin:HI_1529; -.
DR PATRIC; fig|71421.8.peg.1600; -.
DR eggNOG; COG0188; Bacteria.
DR HOGENOM; CLU_002977_4_1_6; -.
DR OMA; PRSNRID; -.
DR PhylomeDB; P43702; -.
DR BioCyc; HINF71421:G1GJ1-1551-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009330; C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex; IBA:GO_Central.
DR GO; GO:0019897; C:extrinsic component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0006265; P:DNA topological change; IBA:GO_Central.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 1.10.268.10; -; 1.
DR Gene3D; 2.120.10.90; -; 1.
DR Gene3D; 3.90.199.10; -; 1.
DR HAMAP; MF_00936; ParC_type1; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR InterPro; IPR005742; TopoIV_A_Gneg.
DR Pfam; PF03989; DNA_gyraseA_C; 2.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; SSF101904; 1.
DR SUPFAM; SSF56719; SSF56719; 1.
PE 3: Inferred from homology;
KW Cell membrane; DNA-binding; Isomerase; Membrane; Reference proteome;
KW Topoisomerase.
FT CHAIN 1..747
FT /note="DNA topoisomerase 4 subunit A"
FT /id="PRO_0000145400"
FT ACT_SITE 124
FT /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00936"
FT SITE 43
FT /note="Interaction with DNA"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00936"
FT SITE 79
FT /note="Interaction with DNA"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00936"
FT SITE 81
FT /note="Interaction with DNA"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00936"
FT SITE 123
FT /note="Transition state stabilizer"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00936"
SQ SEQUENCE 747 AA; 83367 MW; 433038EA479C8D01 CRC64;
MTNINYEGIE QMPLRTFTEK AYLNYSMYVI MDRALPFIGD GLKPVQRRIV YAMSELGLNA
TAKYKKSART VGDVLGKFHP HGDSACYEAM VLMAQPFSYR YPLVDGQGNW GAPDDPKSFA
AMRYTESRLS KISEILLNEL GQGTVDYQPN FDGTLAEPQY LPARLPHILL NGTTGIAVGM
ATDIPPHNIN EIADAAVMLL DNPKAGLDDV LEIVQGPDFP TEAEIISPKS EIRKIYEQGR
GSIKMRATWK KEDGEIIISA LPHQSSPSKV IAQIAEQMTA KKLPMLEDIR DEADHENPIR
IVLVPRSNRV DTDALMAHLF ATTDLEKSYR VNMNMIGLDH KPAVKGLLEI LNEWLDFRRT
TVTRRLQYRL DKVLSRLHIL EGLMIAFLNI DEVIEIIRHE DDPKAELMAR FNLSDEQADA
ILNLRLRHLA KLEENQLKAE QDELEKERLN LEAILGSERR LNTLIKKEIQ EDAKKYANPR
MSQLVEREEA KMISESDMTP AEPVTVILSE MGWVRCAKGH DIDPKSLSYK AGDSYLAHAC
GKSNQAVVFI DSTGRSYALD PLSLPSARSQ GEPLTGKLNL PTGATIEYVV MASEQQELLM
ASDAGYGFIC KFEDLIARNK AGKALISLPE NAKVLKPKTL INSTALVVAI TSAGRMLIFP
AQDLPVLSKG KGNKMITIPA ANAKDRSELL TKLLLISDQA SLEFYSGKRK IVLKPEDLQK
FRAERGRKGS TLPRGLHTNL EIMVIEP
