ID   PARC_TRYBB              Reviewed;         145 AA.
AC   Q06084;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Procyclic form-specific polypeptide B-alpha;
DE   AltName: Full=PARP B-alpha;
DE   AltName: Full=PSSA-1;
DE   AltName: Full=Procyclin;
DE   Flags: Precursor;
GN   Name=PARPB;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2342468; DOI=10.1128/mcb.10.6.3036-3047.1990;
RA   Clayton C.E., Fueri J.P., Itzhaki J.E., Bellofatto V., Sherman D.R.,
RA   Wisdom G.S., Vijayasarathy S., Mowatt M.R.;
RT   "Transcription of the procyclic acidic repetitive protein genes of
RT   Trypanosoma brucei.";
RL   Mol. Cell. Biol. 10:3036-3047(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=427;
RA   Vijayasarathy S., Ernest I., Itzhaki J., Sherman D., Mowatt M.R.,
RA   Michels P.A.M., Clayton C.E.;
RL   Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8420963; DOI=10.1016/s0021-9258(18)53938-7;
RA   Jackson D.G., Smith D.K., Luo C., Elliott J.F.;
RT   "Cloning of a novel surface antigen from the insect stages of Trypanosoma
RT   brucei by expression in COS cells.";
RL   J. Biol. Chem. 268:1894-1900(1993).
CC   -!- FUNCTION: Major surface antigen of procyclic forms.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- DEVELOPMENTAL STAGE: Expressed only at a certain stage during
CC       differentiation in the insect vector.
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DR   EMBL; M33130; AAA30226.1; -; Genomic_DNA.
DR   EMBL; X52585; CAA36816.1; -; Genomic_DNA.
DR   EMBL; L02933; AAA30228.1; -; mRNA.
DR   PIR; A44418; A44418.
DR   AlphaFoldDB; Q06084; -.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008882; Trypano_PARP.
DR   Pfam; PF05887; Trypan_PARP; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Repeat;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   CHAIN           28..123
FT                   /note="Procyclic form-specific polypeptide B-alpha"
FT                   /id="PRO_0000022015"
FT   PROPEP          124..145
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000022016"
FT   REPEAT          59..60
FT                   /note="1"
FT   REPEAT          61..62
FT                   /note="2"
FT   REPEAT          63..64
FT                   /note="3"
FT   REPEAT          65..66
FT                   /note="4"
FT   REPEAT          67..68
FT                   /note="5"
FT   REPEAT          69..70
FT                   /note="6"
FT   REPEAT          71..72
FT                   /note="7"
FT   REPEAT          73..74
FT                   /note="8"
FT   REPEAT          75..76
FT                   /note="9"
FT   REPEAT          77..78
FT                   /note="10"
FT   REPEAT          79..80
FT                   /note="11"
FT   REPEAT          81..82
FT                   /note="12"
FT   REPEAT          83..84
FT                   /note="13"
FT   REPEAT          85..86
FT                   /note="14"
FT   REPEAT          87..88
FT                   /note="15"
FT   REPEAT          89..90
FT                   /note="16"
FT   REPEAT          91..92
FT                   /note="17"
FT   REPEAT          93..94
FT                   /note="18"
FT   REPEAT          95..96
FT                   /note="19"
FT   REPEAT          97..98
FT                   /note="20"
FT   REPEAT          99..100
FT                   /note="21"
FT   REPEAT          101..102
FT                   /note="22"
FT   REPEAT          103..104
FT                   /note="23"
FT   REPEAT          105..106
FT                   /note="24"
FT   REPEAT          107..108
FT                   /note="25"
FT   REPEAT          109..110
FT                   /note="26"
FT   REPEAT          111..112
FT                   /note="27"
FT   REPEAT          113..114
FT                   /note="28"
FT   REPEAT          115..116
FT                   /note="29"
FT   REPEAT          117..118
FT                   /note="30"
FT   REPEAT          119..120
FT                   /note="31"
FT   REPEAT          121..122
FT                   /note="32"
FT   REGION          28..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..122
FT                   /note="32 X 2 AA tandem repeats of [DE]-P"
FT   COMPBIAS        34..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..118
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           123
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   145 AA;  15108 MW;  B6C3B529BD794CE3 CRC64;
     MAPRSLYLLA VLLFSANLFA GVGFAAAAEG PEDKGLTKGG KGKGEKGTKV GADDTNGTDP
     DPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP EPEPEPEPEP
     EPGAATLKSV ALPFAIAAAA LVAAF