ID   PARD1_MYCTU             Reviewed;          83 AA.
AC   P9WIJ7; L0T8D6; P67298; P95254;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Antitoxin ParD1;
GN   Name=parD1; OrderedLocusNames=Rv1960c; ORFNames=MTCY09F9.04;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   EXPRESSION IN E.COLI, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=19016878; DOI=10.1111/j.1574-6968.2008.01400.x;
RA   Gupta A.;
RT   "Killing activity and rescue function of genome-wide toxin-antitoxin loci
RT   of Mycobacterium tuberculosis.";
RL   FEMS Microbiol. Lett. 290:45-53(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in E.coli neutralizes the effect of cognate toxin
CC       ParE1. {ECO:0000269|PubMed:19016878}.
CC   -!- SIMILARITY: Belongs to the ParD antitoxin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL123456; CCP44728.1; -; Genomic_DNA.
DR   PIR; D70639; D70639.
DR   RefSeq; NP_216476.1; NC_000962.3.
DR   RefSeq; WP_003409899.1; NZ_NVQJ01000048.1.
DR   AlphaFoldDB; P9WIJ7; -.
DR   SMR; P9WIJ7; -.
DR   STRING; 83332.Rv1960c; -.
DR   PaxDb; P9WIJ7; -.
DR   DNASU; 885957; -.
DR   GeneID; 885957; -.
DR   KEGG; mtu:Rv1960c; -.
DR   TubercuList; Rv1960c; -.
DR   eggNOG; COG3609; Bacteria.
DR   OMA; VSAGRYK; -.
DR   PhylomeDB; P9WIJ7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0097351; F:toxin sequestering activity; IPI:MTBBASE.
DR   GO; GO:0098754; P:detoxification; IMP:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 6.10.10.120; -; 1.
DR   InterPro; IPR022789; ParD.
DR   InterPro; IPR038296; ParD_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   PANTHER; PTHR36582; PTHR36582; 1.
DR   Pfam; PF03693; ParD_antitoxin; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   TIGRFAMs; TIGR02606; antidote_CC2985; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..83
FT                   /note="Antitoxin ParD1"
FT                   /id="PRO_0000216353"
FT   REGION          54..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          33..60
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   83 AA;  9239 MW;  BC11A37EF0799652 CRC64;
     MGKNTSFVLD EHYSAFIDGE IAAGRYRSAS EVIRSALRLL EDRETQLRAL REALEAGERS
     GSSTPFDFDG FLGRKRADAS RGR