ID   PARD2_CAUVC             Reviewed;          95 AA.
AC   Q9A9D4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Orphan antitoxin ParD2;
GN   Name=parD2; OrderedLocusNames=CC_1054;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Antitoxin component of a non-functional type II toxin-
CC       antitoxin (TA system). Does not neutralize the effect of any of the
CC       RelE or ParE toxins.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype; its associated toxin gene
CC       (parE2, not annotated in UniProtKB) is non-functional.
CC       {ECO:0000269|PubMed:20487277}.
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DR   EMBL; AE005673; AAK23038.1; -; Genomic_DNA.
DR   PIR; B87380; B87380.
DR   RefSeq; NP_419870.1; NC_002696.2.
DR   AlphaFoldDB; Q9A9D4; -.
DR   SMR; Q9A9D4; -.
DR   STRING; 190650.CC_1054; -.
DR   EnsemblBacteria; AAK23038; AAK23038; CC_1054.
DR   KEGG; ccr:CC_1054; -.
DR   PATRIC; fig|190650.5.peg.1071; -.
DR   eggNOG; COG3905; Bacteria.
DR   HOGENOM; CLU_155311_5_2_5; -.
DR   OMA; VELRDWQ; -.
DR   BioCyc; CAULO:CC1054-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; EXP:CollecTF.
DR   InterPro; IPR002145; CopG.
DR   Pfam; PF01402; RHH_1; 1.
PE   4: Predicted;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..95
FT                   /note="Orphan antitoxin ParD2"
FT                   /id="PRO_0000408462"
SQ   SEQUENCE   95 AA;  10962 MW;  B56757CE37579136 CRC64;
     MFWIFVMAKP ASLSIELDSD LDRRLSEIAE GMDQPKTAII ERALRDFVEL RDWQDAAIDE
     GLRAAEEGRV FDHDKVGEWI DSWGTPNERP MPSRD