ID   PARD2_MYCTU             Reviewed;          71 AA.
AC   P9WJ75; F2GKH5; P0CW73; Q8VJP5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Antitoxin ParD2;
GN   Name=parD2; OrderedLocusNames=Rv2142A;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   EXPRESSION IN E.COLI, AND FUNCTION AS AN ANTITOXIN.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=19016878; DOI=10.1111/j.1574-6968.2008.01400.x;
RA   Gupta A.;
RT   "Killing activity and rescue function of genome-wide toxin-antitoxin loci
RT   of Mycobacterium tuberculosis.";
RL   FEMS Microbiol. Lett. 290:45-53(2009).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in E.coli neutralizes the effect of cognate toxin
CC       ParE2. {ECO:0000269|PubMed:19016878}.
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DR   EMBL; AL123456; CCP44918.1; -; Genomic_DNA.
DR   RefSeq; WP_003411127.1; NZ_NVQJ01000044.1.
DR   RefSeq; YP_007410825.1; NC_000962.3.
DR   AlphaFoldDB; P9WJ75; -.
DR   SMR; P9WJ75; -.
DR   STRING; 83332.Rv2142A; -.
DR   GeneID; 14515895; -.
DR   GeneID; 45426120; -.
DR   KEGG; mtu:Rv2142A; -.
DR   TubercuList; Rv2142A; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0097351; F:toxin sequestering activity; IPI:MTBBASE.
DR   GO; GO:0098754; P:detoxification; IMP:MTBBASE.
DR   InterPro; IPR013406; CHP02574_addiction_mod.
DR   TIGRFAMs; TIGR02574; stabl_TIGR02574; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..71
FT                   /note="Antitoxin ParD2"
FT                   /id="PRO_0000408461"
SQ   SEQUENCE   71 AA;  7913 MW;  E220E7401DF5BE2A CRC64;
     MVVNRALLAS VDALSRDEQI ELVEHINGNL AEGMHISEAN QALIEARAND TDDAHWSTID
     DFDKRIRARL G