ID   PARD3_CAUVC             Reviewed;          72 AA.
AC   P0CW74;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Antitoxin ParD3;
GN   Name=parD3; OrderedLocusNames=CC_2755.1;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   IDENTIFICATION, AND POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS AN ANTITOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of cognate toxin ParE3, but no other RelE or
CC       ParE toxin. {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: Cannot be disrupted, suggesting it is a
CC       functional antitoxin. No visible phenotype when the parDE3 operon is
CC       deleted. {ECO:0000269|PubMed:20487277}.
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DR   EMBL; AE005673; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_012640578.1; NC_002696.2.
DR   AlphaFoldDB; P0CW74; -.
DR   SMR; P0CW74; -.
DR   Proteomes; UP000001816; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..72
FT                   /note="Antitoxin ParD3"
FT                   /id="PRO_0000408463"
SQ   SEQUENCE   72 AA;  8202 MW;  01B231D47504AF05 CRC64;
     MNKPAKPAAD DVDDLFGRPL TPAEEDTWFE HNREAIGQLV DEAWAEFERG EYDERSFAEI
     IAQGVAEHNA KR