ID   PARD4_CAUVC             Reviewed;          96 AA.
AC   Q9A458;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Antitoxin ParD4;
GN   Name=parD4; OrderedLocusNames=CC_2985;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
RN   [2]
RP   POSSIBLE FUNCTION.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=15718296; DOI=10.1093/nar/gki201;
RA   Pandey D.P., Gerdes K.;
RT   "Toxin-antitoxin loci are highly abundant in free-living but lost from
RT   host-associated prokaryotes.";
RL   Nucleic Acids Res. 33:966-976(2005).
RN   [3]
RP   FUNCTION AS AN ANTITOXIN, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=20487277; DOI=10.1111/j.1365-2958.2010.07207.x;
RA   Fiebig A., Castro Rojas C.M., Siegal-Gaskins D., Crosson S.;
RT   "Interaction specificity, toxicity and regulation of a paralogous set of
RT   ParE/RelE-family toxin-antitoxin systems.";
RL   Mol. Microbiol. 77:236-251(2010).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the effect of cognate toxin ParE4, but no other RelE or
CC       ParE toxin. {ECO:0000269|PubMed:20487277}.
CC   -!- DISRUPTION PHENOTYPE: Cannot be disrupted, suggesting it is a
CC       functional antitoxin. No visible phenotype when the parDE4 operon is
CC       deleted. {ECO:0000269|PubMed:20487277}.
CC   -!- SIMILARITY: Belongs to the ParD antitoxin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005673; AAK24947.1; -; Genomic_DNA.
DR   PIR; G87618; G87618.
DR   RefSeq; NP_421779.1; NC_002696.2.
DR   AlphaFoldDB; Q9A458; -.
DR   SMR; Q9A458; -.
DR   STRING; 190650.CC_2985; -.
DR   EnsemblBacteria; AAK24947; AAK24947; CC_2985.
DR   KEGG; ccr:CC_2985; -.
DR   PATRIC; fig|190650.5.peg.2991; -.
DR   eggNOG; COG3609; Bacteria.
DR   HOGENOM; CLU_144805_3_1_5; -.
DR   OMA; KDWVEAQ; -.
DR   BioCyc; CAULO:CC2985-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 6.10.10.120; -; 1.
DR   InterPro; IPR022789; ParD.
DR   InterPro; IPR038296; ParD_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   PANTHER; PTHR36582; PTHR36582; 1.
DR   Pfam; PF03693; ParD_antitoxin; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
DR   TIGRFAMs; TIGR02606; antidote_CC2985; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..96
FT                   /note="Antitoxin ParD4"
FT                   /id="PRO_0000408378"
SQ   SEQUENCE   96 AA;  11081 MW;  2429054177138913 CRC64;
     MPSNGIVRSW RRAMATMNVS LPDAMREWVE GQTQSGRYHN ASEYVRDLIR RDQERADKIA
     HLQRLIDEGL DSGVGERSLH EIRAEARRRA GVDHEL